Abstract: Provided herein is a method for treating a disorder ameliorated by muscarinic receptor activation in a patient in need thereof, comprising administering to the patient a muscarinic orthosteric agonist, such as xanomeline and/or a salt thereof and an M1 or M4 muscarinic positive allosteric modulator (PAM). Related pharmaceutical compositions are also provided.

Abstract: The disclosure provides compositions and methods for the Vectored Augmentation of the Destruction, Expression and/or Regulation of proteins, e.g., VA-DER systems and methods.

Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like pol peptides, for the prevention and/or treatment of diseases and/or disorders.

Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.

Abstract: The disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.

Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody like polypeptides, for the prevention and/or treatment of diseases and/or disorders.

Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.

Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.

Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.

Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.

Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody like polypeptides, for the prevention and/or treatment of diseases and/or disorders.

Abstract: An apparatus and method provides automatic reconfiguration of an FPGA, such as in case of lost configuration or configuration error, and software-controlled reconfiguration may be provided that does not require the use of additional devices. An apparatus for FPGA configuration protection comprises watchdog signal generator circuitry in the FPGA configured to output a watchdog signal when the FPGA is properly configured and watchdog circuitry configured to receive the watchdog signal and to initiate reconfiguration of the FPGA if the watchdog signal is not received for or within a predetermined time. The circuitry in the FPGA may be configured to receive a signal from a processor and to output the watchdog signal when the signal from the processor is received.

Abstract: A closure assembly configured to urge a drawer of a refrigerator from an open position that permits access to an interior of the drawer toward a closed position that impedes access to the interior of the drawer. The closure assembly includes a cam block configured to be disposed on one of the drawer and a portion of the refrigerator other than the drawer. The cam block includes a cam surface. A cam member is configured to be disposed on the other one of the drawer and the portion of the refrigerator other than the drawer. The cam member includes a contact surface configured to contact the cam surface to urge the drawer from the open position toward the closed position.

Abstract: An apparatus and method provides automatic reconfiguration of an FPGA, such as in case of lost configuration or configuration error, and software-controlled reconfiguration may be provided that does not require the use of additional devices. An apparatus for FPGA configuration protection comprises watchdog signal generator circuitry in the FPGA configured to output a watchdog signal when the FPGA is properly configured and watchdog circuitry configured to receive the watchdog signal and to initiate reconfiguration of the FPGA if the watchdog signal is not received for or within a predetermined time. The circuitry in the FPGA may be configured to receive a signal from a processor and to output the watchdog signal when the signal from the processor is received.

Abstract: A closure assembly configured to urge a drawer of a refrigerator from an open position that permits access to an interior of the drawer toward a closed position that impedes access to the interior of the drawer. The closure assembly includes a cam block configured to be disposed on one of the drawer and a portion of the refrigerator other than the drawer. The cam block includes a cam surface. A cam member is configured to be disposed on the other one of the drawer and the portion of the refrigerator other than the drawer. The cam member includes a contact surface configured to contact the cam surface to urge the drawer from the open position toward the closed position.

Abstract: The present invention is a method for inhibiting or reducing disease progression in subjects suffering from conditions or diseases related to the A? peptide, including Alzheimer's disease, Down's syndrome, cerebral amyloid angiopathy, mild cognitive impairment, and the like. The method comprises admininstering an apoE2 lentiviral vector to the subject.

Abstract: The present invention is a method for effecting rapid improvement in cognition in subjects suffering from conditions or diseases related to the A? peptide, including Alzheimer's disease, Down's syndrome, cerebral amyloid angiopathy, mild cognitive impairment, and the like. The method comprises administering anti-A? antibodies to the subject, especially antibodies having a high affinity for soluble forms of A?.

Abstract: A method to treat conditions characterized by formation of amyloid plaques both prophylactically and therapeutically is described. The method employs humanized antibodies which sequester soluble A? peptide from human biological fluids or which preferably specifically bind an epitope contained within position 13-28 of the amyloid beta peptide A?.

Abstract: The invention is a device for storing, dispensing and recycling a suspension of regenerating microorganism. The device provides an opening allowing a user to remove a portion of the suspension. The device defines a first area for receipt of new suspension and a second area for dispensing of such suspension for use. Preferably, an angled plate in the interior of the device forms a passage through which the suspension passes towards the dispensing opening. After use, the used suspension is recycled by again pouring the used suspension back into the device through a screen cover. The device allows a user to continue to reuse suspension from the device in that the device recycles such suspension in a manner that allows the microorganism to regenerate as it travels through the device towards the dispensing opening.

Abstract: An auxiliary power supply system includes an internal combustion engine driving an alternator the output of which is rectified and supplied to DC bus lines across which a storage battery is connected. The DC bus lines may supply a consuming device such as an uninterruptible power supply or telecommunications system. The voltage across the bus lines is sensed and when the voltage drops below a selected value, indicating that the consuming devices is drawing power from the battery beyond a desired limit, the engine is turned on for a period of time to warm it up, during which the power from the generator is not supplied to the DC bus lines. Thereafter, the generator supplies power to the DC bus lines to supply the consuming device and partially recharge the battery until the consuming device is no longer drawing power, after which the engine is shut off.