Patents by Inventor Steven Paul Ruddock

Steven Paul Ruddock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human antibodies specific for TGF?2
    Patent number: 7368111
    Abstract: Specific binding members comprising human antibody antigen binding domains specific for human transforming growth factor beta (TGF?) bind specifically isoforms TGF?2 and TGF?1 or both, preferentially compared with TGF?3. Specific binding members may be isolated and utilized in the treatment of disease, particularly fibrotic disease and also immune/inflammatory diseases. Therapeutic utility is demonstrated using in vitro and in vivo models. Full sequence and binding information is provided, including epitope sequence information for particularly advantageous specific binding member which binds the active form of TGF?2, neutralizing its activity, but does not bind the latent member.
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: May 6, 2008
    Assignees: Cambridge Antibody Technology Limited, Medical Research Council
    Inventors: Julia Elizabeth Thompson, Tristan John Vaughan, Andrew James Williams, Jonathan Alexander Green, Ronald Henry Jackson, Louise Bacon, Kevin Stuart Johnson, Alison Jane Wilton, Philip Ronald Tempest, Raymond Paul Field, Steven Paul Ruddock, Gregory Paul Winter