Patents by Inventor Steven Peter Armes
Steven Peter Armes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240117098Abstract: The invention provides non-crosslinked and crosslinked block copolymers comprising at least one block A comprising repeating units derived from monomers comprising one or more C1-C3 alkyl (meth)acrylamides and/or (meth)acrylates and at least one block B comprising repeating units derived from monomers comprising one or more C4-C40 alkyl (meth)acrylamides. The invention further provides compositions comprising the block copolymers and applications thereof in various industrial areas including personal care. The invention furthermore provides compositions comprising colloidal particles of the block copolymers. The variables x, y, R1, and R2 are described herein.Type: ApplicationFiled: November 30, 2021Publication date: April 11, 2024Applicant: ISP Investments LLCInventors: Rebecca Roisin Gibson, ALAN FERNYHOUGH, OSAMA M. MUSA, Steven Peter ARMES
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Publication number: 20240059806Abstract: The invention provides a process for removal of a thio-based end group from a polymer comprising repeating units derived from at least one monomer comprising at least one acryloyl moiety and at least one functionalized or unfunctionalized lactam moiety by subjecting the polymer to radiation in a reaction medium devoid of any chemical reagent. Exemplary process involves removal of thio-based end groups from polymers prepared by reversible addition-fragmentation chain transfer polymerization of at least one monomer comprising at least one acryloyl moiety and at least one functionalized or unfunctionalized lactam moiety by exposing the polymer to visible radiation in a reaction medium devoid of any chemical reagent.Type: ApplicationFiled: January 6, 2022Publication date: February 22, 2024Applicant: ISP Investments LLCInventors: OSAMA M. MUSA, Rebecca Roisin GIBSON, Steven Peter ARMES
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Patent number: 11859029Abstract: The invention provides a method for preparation of homopolymers and non-homopolymers comprising polymerizing in an aqueous medium a monomer comprising at least one acryloyl moiety and at least one functionalized or unfunctionalized lactam moiety, and optionally at least one hydrophilic or hydrophobic comonomer, in the presence of at least one chain transfer agent and at least one non-radiation initiator. Exemplary diblock polymers prepared by the method have the structure: where subscripts x, y, and z and variables R, R8, R9 and R10 are described herein.Type: GrantFiled: February 10, 2020Date of Patent: January 2, 2024Assignee: ISP INVESTMENTS LLCInventors: Oliver Johnathan Deane, Osama M. Musa, Steven Peter Armes, Alan Fernyhough, Rebecca Roisin Gibson
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Patent number: 10905636Abstract: The invention provides block copolymers comprising at least one block A comprising repeating units derived from monomers comprising lactam and acryloyl moieties and at least one block B comprising repeating units derived from hydrophobic monomers. The invention further provides compositions comprising the block copolymers and applications thereof in various industrial areas including personal care. The invention furthermore provides compositions comprising colloidal particles of the block copolymers. The variables x, y, R8 and R9 are described herein.Type: GrantFiled: January 11, 2017Date of Patent: February 2, 2021Assignee: ISP INVESTMENTS LLCInventors: Osama M. Musa, Victoria Jane Cunningham, Steven Peter Armes
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Publication number: 20200407470Abstract: The invention provides a method for preparation of homopolymers and non-homopolymers comprising polymerizing in an aqueous medium a monomer comprising at least one acryloyl moiety and at least one functionalized or unfunctionalized lactam moiety, and optionally at least one hydrophilic or hydrophobic comonomer, in the presence of at least one chain transfer agent and at least one non-radiation initiator. Exemplerary diblock polymers prepared by the method have the structure: where subscripts x, y, and z and variables R, R8, R9 and R10 are described herein.Type: ApplicationFiled: February 10, 2020Publication date: December 31, 2020Applicant: ISP INVESTMENTS LLCInventors: Oliver Johnathan DEANE, Osama M. Musa, Steven Peter Armes
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Publication number: 20190382519Abstract: This application provides cross-linked block copolymers comprising at least one block comprising repeating units derived from monomers comprising lactam and acryloyl moieties. The application further provides compositions comprising the block copolymers and applications thereof in various industrial areas including personal care. The application furthermore provides Pickering emulsion compositions comprising the block copolymers.Type: ApplicationFiled: January 11, 2018Publication date: December 19, 2019Applicant: ISP INVESTMENTS LLCInventors: Osama M. MUSA, Victoria Jane Cunningham, Steven Peter Armes
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Publication number: 20190375875Abstract: This application provides high molecular weight block copolymers comprising at least one block A comprising repeating units derived from monomers comprising lactam and acryloyl moieties and at least one block B comprising repeating units derived from hydrophilic monomers. The application further provides compositions comprising the block copolymers and applications thereof in various industrial areas including personal care. The application furthermore provides compositions comprising colloidal particles of the block copolymers. The variables x, y, R8 and R9 are described herein (I). Wherein each x and y is independently an integer having a value from about 10 to about 10000, and each R8, and R9 is independently selected from the group consisting of hydrogen, methyl, and combinations thereof.Type: ApplicationFiled: January 9, 2018Publication date: December 12, 2019Applicant: ISP INVESTMENTS LLCInventors: Osama M. Musa, Victoria Jane Cunningham, Steven Peter Armes
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Publication number: 20190015304Abstract: The invention provides block copolymers comprising at least one block A comprising repeating units derived from monomers comprising lactam and acryloyl moieties and at least one block B comprising repeating units derived from hydrophobic monomers. The invention further provides compositions comprising the block copolymers and applications thereof in various industrial areas including personal care. The invention furthermore provides compositions comprising colloidal particles of the block copolymers. The variables x, y, R8 and R9 are described herein.Type: ApplicationFiled: January 11, 2017Publication date: January 17, 2019Applicant: ISP INVESTMENTS LLCInventors: Osama M. MUSA, Victoria Jane CUNNINGHAM, Steven Peter ARMES
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Patent number: 10150946Abstract: The present invention relates to a medium for storing, preserving, culturing, and/or differentiating stem cells. The medium employs a synthetic thermo-responsive copolymer, dispersed in an aqueous vehicle, which allows the medium to be readily “switched” between a non-gelatinous (fluid) form and a gelatinous form by simply adjusting temperature across the gelling temperature of the medium. As such, stem cells can be easily captured within a 3D gel matrix by simply mixing the stem cells with the non-gelatinous/fluid form of the medium and then gelling the medium by adjusting the temperature across the gelling temperature of the medium. The stem cells encapsulated within the gelatinous form of the medium may then be preserved for a significant time period before either using the stem cells directly within the medium (e.g. in therapy, or in culturing, differentiation, and such like), or after their extraction from the medium.Type: GrantFiled: February 21, 2014Date of Patent: December 11, 2018Assignee: The University of SheffieldInventors: Irene Canton, Steven Peter Armes, Nicholas John Warren, Harry Moore, Giuseppe Battaglia, Denis Cecchin
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Patent number: 9765213Abstract: An aqueous composition comprises an amphiphilic block copolymer, having a hydrophilic block comprising pendant zwitterionic groups and a hydrophobic block, and a biologically active compound associated with the polymer. The polymer is preferably in the form of micelles, and preferably the biological active is a hydrophobic drug. The hydrophilic block is preferably formed from acrylic monomer including phosphorylcholine groups. The hydrophobic group is suitably formed from monomer which has groups which can be ionised at useful pH's, especially tertiary amine groups. Micelles may be formed by dissolving the block copolymer in aqueous solvent at a pH at which the amine groups are protonated then raising the pH to a value at which the amine groups are substantially deprotonated, whereupon micelles spontaneously form. The preformed micelles are then contacted with active, under conditions such that solubilisation of the active occurs. The active may be for tumour treatment.Type: GrantFiled: January 23, 2012Date of Patent: September 19, 2017Assignee: BIOCOMPATIBLES UK LIMITEDInventors: Andrew Leonard Lewis, Steven Peter Armes, Andrew W. Lloyd, Jonathan P. Salvage
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Publication number: 20150376567Abstract: The present invention relates to a medium for storing, preserving, culturing, and/or differentiating stem cells. The medium employs a synthetic thermo-responsive copolymer, dispersed in an aqueous vehicle, which allows the medium to be readily “switched” between a non-gelatinous (fluid) form and a gelatinous form by simply adjusting temperature across the gelling temperature of the medium. As such, stem cells can be easily captured within a 3D gel matrix by simply mixing the stem cells with the non-gelatinous/fluid form of the medium and then gelling the medium by adjusting the temperature across the gelling temperature of the medium. The stem cells encapsulated within the gelatinous form of the medium may then be preserved for a significant time period before either using the stem cells directly within the medium (e.g. in therapy, or in culturing, differentiation, and such like), or after their extraction from the medium.Type: ApplicationFiled: February 21, 2014Publication date: December 31, 2015Applicant: The University of SheffieldInventors: Irene Canton, Steven Peter Armes, Nicholas John Warren, Harry Moore, Guiseppe Battaglia, Denis Cecchin
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Publication number: 20120157550Abstract: An aqueous composition comprises an amphiphilic block copolymer, having a hydrophilic block comprising pendant zwitterionic groups and a hydrophobic block, and a biologically active compound associated with the polymer. The polymer is preferably in the form of micelles, and preferably the biological active is a hydrophobic drug. The hydrophilic block is preferably formed from acrylic monomer including phosphorylcholine groups. The hydrophobic group is suitably formed from monomer which has groups which can be ionised at useful pH's, especially tertiary amine groups. Micelles may be formed by dissolving the block copolymer in aqueous solvent at a pH at which the amine groups are protonated then raising the pH to a value at which the amine groups are substantially deprotonated, whereupon micelles spontaneously form. The preformed micelles are then contacted with active, under conditions such that solubilisation of the active occurs. The active may be for tumour treatment.Type: ApplicationFiled: January 23, 2012Publication date: June 21, 2012Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Andrew Lennard LEWIS, Steven Peter ARMES, Andrew W. LLOYD, Jonathan P. SALVAGE
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Patent number: 8182802Abstract: Compositions are described comprising a of a block copolymer having an overall ionic charge and in which one of the blocks has pendant zwitterionic groups and a biologically active compound having a charge opposite that of the polymer. The polymer is preferably a linear diablock copolymer, preferably having a low polydispersity, such as a (tertiary amine group containing monomer) block-(zwitterionic monomer) copolymer. Suitable cationic monomers are dialkyl aminoalkyl(alk)acrylates and -acrylamides and suitable zwitterionic monomers are phosphorylcholine group containing acrylate monomers such as 2-methacyloyloxyetyl-21-trimethyl ammonium ethyl phosphate liner salt. The biologically active compound is generally polyionic and is for instance a nucleic acid, such as DNA, especially plasmid DNA.Type: GrantFiled: March 7, 2003Date of Patent: May 22, 2012Assignee: Biocompatibles UK LimitedInventors: Andrew Lennard Lewis, Steven Peter Armes
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Patent number: 7820753Abstract: Block copolymers comprise a core block formed of hydrophilic monomers and have pendant zwitterionic groups, and at least two terminal blocks, comprising stimulus-responsive groups. The core block has a degree of polymerisation of at least 100, whilst the terminal blocks have an average degree of polymerisation of at least 20. A solution of polymer in a liquid may be caused to change its characteristics, for instance rheology, upon being subjected to a stimulus such as a change in temperature or pH. Examples comprise core blocks formed of 2-methacryloyloxyethyl-2?-trimethylammonium ethylphosphate inner salt (MPC) and terminal blocks formed of 2-(diisopropylamino)ethyl methacrylate. Upon changing the pH from around 2 to around 8, an aqueous solution of the block copolymer gels, the solution becoming mobile again upon lowering the pH. The effect is due to deprotonation of a quaternary ammonium pendant ion to form a non-ionised group and subsequent protonation to form an ionised group.Type: GrantFiled: February 5, 2004Date of Patent: October 26, 2010Assignee: Biocompatibles UK LimitedInventors: Andrew Lennard Lewis, Steven Peter Armes, Yinghua Ma
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Patent number: 7300990Abstract: Polymers may be made from zwitterionic monomers having controlled architectures and molecular weights, using living polymerisations such as group or atom transfer radical polymerisation. For instance polymers may be formed by atom transfer radical polymerisation using a copper chloride catalyst, a ligand which is water soluble, and a water soluble tertiary alkyl halide initiator to form homopolymers having controlled polydispersities of less than 1.5 and block copolymers with other hydrophilic or hydrophobic monomers. One suitable zwitterionic monomer is 2-methacryloyloxy-2?-trimethylammoniumethyl phosphate inner salt. The block copolymers may spontaneously form micelles, believed to have zwitterionic, for instance phosphorylcholine, groups at the external surface, which may be useful as drug delivery systems with improved biocompatibility.Type: GrantFiled: January 3, 2005Date of Patent: November 27, 2007Assignee: Biocompatibles UK LimitedInventors: Andrew Lennard Lewis, Sean Leo Willis, Steven Peter Armes, Emma Janice Lobb, Yinghua Ma
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Patent number: 6852816Abstract: Polymers may be made from zwitterionic monomers having controlled architectures and molecular weights, using living polymerisations such as group or atom transfer radical polymerisation. For instance polymers may be formed by atom transfer radical polymerisation using a copper chloride catalyst, a ligand which is water soluble, and a water soluble tertiary alkyl halide initiator to form homopolymers having controlled polydispersities of less than 1.5 and block copolymers with other hydrophilic or hydrophobic monomers. One suitable zwitterionic monomer is 2-methacryloyloxy-2?-trimethylammoniumethyl phosphate inner salt. The block copolymers may spontaneously form micelles, believed to have zwitterionic, for instance phosphorylcholine, groups at the external surface, which may be useful as drug delivery systems with improved biocompatibility.Type: GrantFiled: October 5, 2001Date of Patent: February 8, 2005Assignee: Biocompatibles UK LimitedInventors: Andrew Lennard Lewis, Sean Leo Willis, Steven Peter Armes, Emma Janice Lobb, Yinghua Ma
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Publication number: 20040063881Abstract: Polymers may be made from zwitterionic monomers having controlled architectures and molecular weights, using living polymerisations such as group or atom transfer radical polymerisation. For instance polymers may be formed by atom transfer radical polymerisation using a copper chloride catalyst, a ligand which is water soluble, and a water soluble tertiary alkyl halide initiator to form homopolymers having controlled polydispersities of less than 1.5 and block copolymers with other hydrophilic or hydrophobic monomers. One suitable zwitterionic monomer is 2-methacryloyloxy-2′-trimethylammoniumethyl phosphate inner salt. The block copolymers may spontaneously form micelles, believed to have zwitterionic, for instance phosphorylcholine, groups at the external surface, which may be useful as drug delivery systems with improved biocompatibility.Type: ApplicationFiled: October 20, 2003Publication date: April 1, 2004Inventors: Andrew Lennard Lewis, Sean Leo Willis, Steven Peter Armes, Emma Janice Lobb, Yinghua Ma