Abstract: The present invention provides processes of synthesis and purification of a bromodomain inhibitor, Compound 1, which compound includes crystalline forms, amorphous forms, solvates, and hydrates thereof. Embodiments of the disclosure relate to chemical synthesis routes of Compound 1 that provide a scalable method that results in highly pure final product. A further embodiment relates to methods to isolate the most stable polymorph of Compound 1 by crystallization from formic acid and water.

Abstract: The present invention provides processes of synthesis and purification of a bromodomain inhibitor, Compound 1, which compound includes crystalline forms, amorphous forms, solvates, and hydrates thereof. Embodiments of the disclosure relate to chemical synthesis routes of Compound 1 that provide a scalable method that results in highly pure final product. A further embodiment relates to methods to isolate the most stable polymorph of Compound 1 by crystallization from formic acid and water.

Abstract: The present invention provides processes of synthesis and purification of a bromodomain inhibitor, Compound 1, which compound includes crystalline forms, amorphous forms, solvates, and hydrates thereof. Embodiments of the disclosure relate to chemical synthesis routes of Compound 1 that provide a scalable method that results in highly pure final product. A further embodiment relates to methods to isolate the most stable polymorph of Compound 1 by crystallization from formic acid and water.

Abstract: Systems and methods for training users to more proficiently make wildlife calls, whether for hunting or other purposes, are described herein. For instance, an embodiment of an interactive learning system can train an enthusiast to more consistently and proficiently make calls that are efficacious with attracting wildlife. The system may implement advanced signal processing techniques that can compare a user-generated signal (attempting to mimic a wildlife call) with a prerecorded wildlife call. The system may provide feedback to the user to enable the user to assess his or her performance in reproducing the wildlife call. The user can use the feedback to improve reproduction of the wildlife call.

Abstract: Systems and methods for training users to more proficiently make wildlife calls, whether for hunting or other purposes, are described herein. For instance, an embodiment of an interactive learning system can train an enthusiast to more consistently and proficiently make calls that are efficacious with attracting wildlife. The system may implement advanced signal processing techniques that can compare a user-generated signal (attempting to mimic a wildlife call) with a prerecorded wildlife call. The system may provide feedback to the user to enable the user to assess his or her performance in reproducing the wildlife call. The user can use the feedback to improve reproduction of the wildlife call.

Abstract: Systems and methods for training users to more proficiently make wildlife calls, whether for hunting or other purposes, are described herein. For instance, an embodiment of an interactive learning system can train an enthusiast to more consistently and proficiently make calls that are efficacious with attracting wildlife. The system may implement advanced signal processing techniques that can compare a user-generated signal (attempting to mimic a wildlife call) with a prerecorded wildlife call. The system may provide feedback to the user to enable the user to assess his or her performance in reproducing the wildlife call. The user can use the feedback to improve reproduction of the wildlife call.