Patents by Inventor Steven R. Childers

Steven R. Childers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclopropyl derivatives and methods of use
    Patent number: 10207984
    Abstract: The disclosure relates to cyclopropyl derivatives and methods of use. In some embodiments, the disclosure relates to methods of managing medical disorders with pharmaceutical compositions disclosed herein administered to subject in need thereof. In certain embodiments, the disclosure relates to methods of managing mental disorders, mood disorders, pain, and fibromyalgia and related conditions with pharmaceutical compositions disclosed herein.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: February 19, 2019
    Assignees: Emory University, Wake Forest University Health Services
    Inventors: Huw M. L. Davies, Spandan Chennamadhavuni, Thomas J. Martin, Steven R. Childers
  • Cyclopropyl Derivatives and Methods of Use
    Publication number: 20160244403
    Abstract: The disclosure relates to cyclopropyl derivatives and methods of use. In some embodiments, the disclosure relates to methods of managing medical disorders with pharmaceutical compositions disclosed herein administered to subject in need thereof. In certain embodiments, the disclosure relates to methods of managing mental disorders, mood disorders, pain, and fibromyalgia and related conditions with pharmaceutical compositions disclosed herein.
    Type: Application
    Filed: May 3, 2016
    Publication date: August 25, 2016
    Inventors: Huw M. Davies, Spandan Chennamadhavuni, Thomas J. Martin, Steven R. Childers
  • Sigma-2 receptors as biomarkers of tumor cell proliferation
    Patent number: 6676925
    Abstract: Detectably-labeled compounds of formula (I) wherein A,B,C,D,E,F,R,X,Y and Z have any of the meanings given in the specification, and their pharmaceutically acceptable salts, are useful in competitive assays to assay for the presence of 2 receptors. Also disclosed are pharmaceutical compositions containing such a compound of formula (I), methods for their use and intermediates useful for preparing such compounds of formula (I).
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: January 13, 2004
    Assignee: Wake Forest University
    Inventors: Robert H. Mach, Kenneth T. Wheeler, Biao Yang, Steven R. Childers
  • .sigma.-2 receptors as biomarkers of tumor cell proliferation
    Patent number: 6113877
    Abstract: The invention provides detectably-labeled compounds of formula (I): ##STR1## wherein A, B, C, D, E, F, R, X, Y and Z have any of the meanings given in the specification, and their pharmaceutically acceptable salts, are useful in competitive assays to assay for the presence of .sigma.2 receptors. Also disclosed are pharmaceutical compositions containing such a compound of formula (I), methods for their use and intermediates useful for preparing such compounds of formula (I).
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: September 5, 2000
    Assignee: Wake Forest University
    Inventors: Robert H. Mach, Kenneth T. Wheeler, Biao Yang, Steven R. Childers
  • Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression
    Patent number: 6013242
    Abstract: Biologically active derivatives of the tropane ring system are provided which selectively bind either to the 5-HT or DA reuptake site, leading to compounds which have use for the treatment of clinical depression, attention deficit disorder, obesity and cocaine addiction.
    Type: Grant
    Filed: January 13, 1998
    Date of Patent: January 11, 2000
    Assignees: Wake Forest University, The Research Foundation of State University of New York
    Inventors: Huw M. L. Davies, Norman Kong, Steven R. Childers
  • Process for blocking 5-HT and dopamine uptake with biologically active tropane derivatives
    Patent number: 6008227
    Abstract: Selective blockade of DA and 5-HT uptake sites with 3-aryltropane derivatives.
    Type: Grant
    Filed: May 18, 1993
    Date of Patent: December 28, 1999
    Assignee: Wake Forest University
    Inventors: Huw M. L. Davies, Steven R. Childers, Barbara Bennett
  • Biologically active tropane derivatives
    Patent number: 5763455
    Abstract: Selective blockade of DA and 5-HT uptake sites with 3-aryltropane derivatives.
    Type: Grant
    Filed: June 13, 1997
    Date of Patent: June 9, 1998
    Assignee: Wake Forest University
    Inventors: Huw M. L. Davies, Steven R. Childers
  • 2 step process for preparing biologically active tropane derivatives and starting material therefore
    Patent number: 5342949
    Abstract: Preparation of biologically active tropane derivatives of novel configurations. The compounds are prepared by decomposing vinyldiazomethanes in the presence of pyrroles to provide a bicyclic ring containing the basic tropane ring system which is then reacted with an aryl Grignard reagent in the presence of a copper (I) or (II) salt to provide 3-aryl-tropane derivatives.
    Type: Grant
    Filed: November 17, 1992
    Date of Patent: August 30, 1994
    Assignee: Wake Forest University
    Inventors: Huw M. L. Davies, Elie Saikali, Steven R. Childers
  • Biologically active tropane derivatives
    Patent number: 5262428
    Abstract: Preparation of biologically active tropane derivatives of novel configurations. The compounds are prepared by decomposing vinyldiazomethanes in the presence of pyrroles to provide a bicyclic ring containing the basic tropane ring system which is then reacted with an aryl Grignard reagent in the presence of a copper (I) or (II) salt to provide 3-aryltropane derivatives.
    Type: Grant
    Filed: March 13, 1992
    Date of Patent: November 16, 1993
    Assignee: Wake Forest University
    Inventors: Huw M. L. Davies, Elie Saikali, Steven R. Childers