Patents by Inventor Steven R. Crowley

Steven R. Crowley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glaucoma treatment
    Patent number: 5346887
    Abstract: A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: ##STR1## wherein A is a substituent; W is CO or CHOH and U is CH.sub.2 or NR.sub.2 wherein R.sub.2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH.sub.2 ; R.sub.1 is loweralkyl, cycloalkylmethyl, benzyl, (alpha, alpha) -dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, 1-benzyloxyethyl, phenethyl, phenoxy, thiophenoxy or anilino; R.sub.3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)loweralkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R.sub.4 is substituted hydroxyalkylamino.
    Type: Grant
    Filed: April 23, 1991
    Date of Patent: September 13, 1994
    Assignee: Abbott Laboratories
    Inventors: Herman H. Stein, Jacob J. Plattner, Steven R. Crowley
  • Psoriasis treatment
    Patent number: 5122514
    Abstract: The present invention relates to the use of renin inhibitors and to renin inhibitor compositions for treatment of psoriasis.
    Type: Grant
    Filed: April 9, 1991
    Date of Patent: June 16, 1992
    Assignee: Abbott Laboratories
    Inventors: Robert S. Boger, Steven R. Crowley
  • Peptidyl aminodiol renin inhibitors
    Patent number: 5063208
    Abstract: A renin inhibiting compound having an aminodiol functional group is useful for treating hypertension, congestive heart failure and glaucoma and inhibits retroviral protease.
    Type: Grant
    Filed: June 29, 1990
    Date of Patent: November 5, 1991
    Assignee: Abbott Laboratories
    Inventors: Saul H. Rosenberg, Kenneth P. Spina, Steven R. Crowley
  • Glaucoma treatment
    Patent number: 5059589
    Abstract: A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: ##STR1## wherein A is a substituent; W is CO or CHOH and U is CH.sub.2 or NR.sub.2 wherein R.sub.2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH.sub.2 ; R.sub.1 is loweralkyl, cycloalkylmethyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, 1-bezyloxyethyl, phenethyl, phenoxy, thiophenoxy or anilino; R.sub.3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)loweralkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R.sub.4 is substituted hydroxyalkylamino.
    Type: Grant
    Filed: March 2, 1990
    Date of Patent: October 22, 1991
    Assignee: Abbott Laboratories
    Inventors: Herman H. Stein, Jacob J. Plattner, Steven R. Crowley
  • Glaucoma treatment
    Patent number: 4927807
    Abstract: A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: ##STR1## wherein A is a substituent; W is CO or CHOH and U is CH.sub.2 or NR.sub.2 wherein R.sub.2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH.sub.2 ; R.sub.1 is loweralkyl, cycloalkyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino; R.sub.3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R.sub.4 is a substituted amino group; or pharmaceutically acceptable salts or esters thereof.
    Type: Grant
    Filed: September 8, 1988
    Date of Patent: May 22, 1990
    Assignee: Abbott Laboratories
    Inventors: Herman H. Stein, Jacob J. Pattner, Steven R. Crowley