Abstract: Apparatus for delivering a therapeutic agent to a uterine cavity including an elongated member having a fluid channel for passage of the therapeutic agent into the uterine cavity, a dispensing member extending distally of the elongated member and having at least one perforation for passage of the therapeutic agent into the uterine cavity into contact with the endometrium. An infusion line is in communication with the fluid channel for passage of a fluid into the uterine cavity to assess leakage to determine integrity of the uterine cavity prior to passage of the therapeutic agent into the uterine cavity.

Abstract: Apparatus for delivering a therapeutic agent to a uterine cavity including an elongated member having a fluid channel for passage of the therapeutic agent into the uterine cavity, a dispensing member extending distally of the elongated member and having at least one perforation for passage of the therapeutic agent into the uterine cavity into contact with the endometrium. An infusion line is in communication with the fluid channel for passage of a fluid into the uterine cavity to assess leakage to determine integrity of the uterine cavity prior to passage of the therapeutic agent into the uterine cavity.

Abstract: The present disclosure provides pharmaceutical compositions that include one or more selective estrogen receptor modulator(s) (SERM(s), e.g., Lasofoxifene) and four or more pharmaceutically acceptable excipients. The pharmaceutical compositions may be able to form nanodroplets (e.g., by self-nanoemulsifying) in vaginal fluid and to deliver the one or more SERM(s) to the vagina of a female subject. The pharmaceutical compositions may be useful in treating or preventing vulvovaginal atrophy, dyspareunia, sexual dysfunction, osteoporosis, or breast cancer in a female subject.

Abstract: An apparatus for delivering an agent to a uterine cavity of a patient for endometrial ablation including a first passage for passage of the agent into the cavity of the patient and a second passage for aspirating the agent from the uterine cavity, wherein the agent is injected at an increased pressure and is injected simultaneously with aspiration of the cavity. A cavity integrity check prior to injection of the agent can be conducted with the apparatus.

Abstract: Apparatus for delivering a therapeutic agent to a uterine cavity including an elongated member having a fluid channel for passage of the therapeutic agent into the uterine cavity, a dispensing member extending distally of the elongated member and having at least one perforation for passage of the therapeutic agent into the uterine cavity into contact with the endometrium. An infusion line is in communication with the fluid channel for passage of a fluid into the uterine cavity to assess leakage to determine integrity of the uterine cavity prior to passage of the therapeutic agent into the uterine cavity.

Abstract: Apparatus for delivering a therapeutic agent to a uterine cavity including an elongated member having a fluid channel for passage of the therapeutic agent into the uterine cavity, a dispensing member extending distally of the elongated member and having at least one perforation for passage of the therapeutic agent into the uterine cavity into contact with the endometrium. An infusion line is in communication with the fluid channel for passage of a fluid into the uterine cavity to assess leakage to determine integrity of the uterine cavity prior to passage of the therapeutic agent into the uterine cavity.

Abstract: Apparatus for delivering a therapeutic agent to a uterine cavity including an elongated member having a fluid channel for passage of the therapeutic agent into the uterine cavity, a dispensing member extending distally of the elongated member and having at least one perforation for passage of the therapeutic agent into the uterine cavity into contact with the endometrium. An infusion line is in communication with the fluid channel for passage of a fluid into the uterine cavity to assess leakage to determine integrity of the uterine cavity prior to passage of the therapeutic agent into the uterine cavity.

Abstract: Apparatus for delivering a therapeutic agent to a uterine cavity including an elongated member having a fluid channel for passage of the therapeutic agent into the uterine cavity, a dispensing member extending distally of the elongated member and having at least one perforation for passage of the therapeutic agent into the uterine cavity into contact with the endometrium. An infusion line is in communication with the fluid channel for passage of a fluid into the uterine cavity to assess leakage to determine integrity of the uterine cavity prior to passage of the therapeutic agent into the uterine cavity.

Abstract: The present disclosure provides pharmaceutical compositions that include one or more selective estrogen receptor modulator(s) (SERM(s), e.g., Lasofoxifene) and four or more pharmaceutically acceptable excipients. The pharmaceutical compositions may be able to form nanodroplets (e.g., by self-nanoemulsifying) in vaginal fluid and to deliver the one or more SERM(s) to the vagina of a female subject. The pharmaceutical compositions may be useful in treating or preventing vulvovaginal atrophy, dyspareunia, sexual dysfunction, osteoporosis, or breast cancer in a female subject.

Abstract: A device for chemical endometrial ablation comprising an outer tube, a moveable cervical collar surrounding a portion of the outer tube and located near the distal end of the outer tube, an inner tube movable in a distal-proximal direction within the lumen of the outer tube, a porous and/or sponge-like material on the distal end of the inner tube within the lumen of the distal end of the outer tube having a size, shape, and expandability so that when the distal end of the inner tube within the distal end of the outer tube is moved in a distal direction in relation to the outer tube, the porous and/or sponge-like material expands to the approximate size of a uterus so as to contact the endometrium, a source of cauterizing agent, and means to cause the cauterizing agent to flow through the lumen of the inner tube onto the porous and/or sponge-like material.

Abstract: A device for chemical endometrial ablation comprising an outer tube, a moveable cervical collar surrounding a portion of the outer tube and located near the distal end of the outer tube, an inner tube movable in a distal-proximal direction within the lumen of the outer tube, a porous and/or sponge-like material on the distal end of the inner tube within the lumen of the distal end of the outer tube having a size, shape, and expandability so that when the distal end of the inner tube within the distal end of the outer tube is moved in a distal direction in relation to the outer tube, the porous and/or sponge-like material expands to the approximate size of a uterus so as to contact the endometrium, a source of cauterizing agent, and means to cause the cauterizing agent to flow through the lumen of the inner tube onto the porous and/or sponge-like material.

Abstract: A device is provided for instilling a fluid into the cavity of the uterus which avoids various disadvantages inherent in prior art devices, e.g., patient discomfort, an adjustable seal to accommodate varying dimensions of the uterus of the patient, a non-invasive, non-surgical procedure that could be performed in a relatively short period of time with little risk to the patient. The device provides a simple design to accomplish the ends described above and avoiding more complex designs including more complex procedures inherent in prior art devices. Moreover, the device and procedure may provide an even more definitive and reliable diagnostic means for the detection of abnormalities, polyps and tumors and to measure and monitor endometrial thickness within the uterus.