Patents by Inventor Steven R. Jefferies

Steven R. Jefferies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4772284
    Abstract: A single lumen implantable and biocompatible breast prosthesis composed of an outer membrane of silastic, medical grade silicone, and an inner filling material selected from the group consisting of purified reconstituted collagen gel and a purified gel of poly-alpha amino acid homopolymers or random copolymers having a molecular weight of from 5,000 to 400,000. The purified reconstituted collagen gel has a collagen concentration of from 20 to 100 milligrams per milliliter of gel.
    Type: Grant
    Filed: March 27, 1986
    Date of Patent: September 20, 1988
    Assignee: Collagenix Corporation
    Inventors: Steven R. Jefferies, Robert J. Spence
  • Patent number: 4472840
    Abstract: Complexes of reconstituted collagen and demineralized bone particles or reconstituted collagen and a solubilized bone morphogenetic protein fabricated in a sponge suitable for in vivo implantation in osseous defects are disclosed. Both demineralized bone particles (DBP) and bone morphogenetic protein have demonstrated the ability to induce the formation of osseous tissue in animal and human experiments. Reconstituted collagen conjugate is highly biocapatible and can be fabricated in a variety of configurations, especially as a sponge. This material can be used as a grafting implant in plastic and reconstructive surgery, periodontal bone grafting, and in endodontic procedures. Structural durability is enhanced by cross-linking with glutaraldehyde which is also used to sterilize and disinfect the collagen conjugate prior to implantation.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: September 25, 1984
    Inventor: Steven R. Jefferies
  • Patent number: 4409332
    Abstract: Collagen polymers are rendered non-inflammatory by complexation with alkaline phosphatase according to the procedure disclosed. Applications of these non-inflammatory collagen complexes include the production of non-inflammatory collagen sutures, collagen soft tissue replacements including wound and burn coverings and arterial vessel replacements, collagen drug delivery devices, and vitreous replacement for opthalmologic therapy. Gels composed of the collagen-alkaline phosphatase conjugate plus calcium hydroxide are useful as an agent in endodontic therapy. Structural durability and stabilization of the anti-inflammatory properties of the material are enhanced by crosslinking with glutaraldehyde or other crosslinking agents. Glutaraldehyde also acts to sterilize and disinfect the collagen conjugate prior to in-vivo use.
    Type: Grant
    Filed: January 12, 1982
    Date of Patent: October 11, 1983
    Inventors: Steven R. Jefferies, James L. Gutmann, Barry M. Heatfield
  • Patent number: 4394370
    Abstract: Complexes of reconstituted collagen and demineralized bone particles or reconstituted collagen and a solubilized bone morphogenetic protein fabricated in a sponge suitable for in vivo implantation in osseous defects are disclosed. Both demineralized bone particles (DBP) and bone morphogenetic protein have demonstrated the ability to induce the formation of osseous tissue in animal and human experiments. Reconstituted collagen conjugate is highly biocapatible and can be fabricated in a variety of configurations, especially as a sponge. This material can be used as a grafting implant in plastic and reconstructive surgery, periodontal bone grafting, and in endodontic procedures. Structural durability is enhanced by cross-linking with glutaraldehyde which is also used to sterilize and disinfect the collagen conjugate prior to implantation.
    Type: Grant
    Filed: September 21, 1981
    Date of Patent: July 19, 1983
    Inventor: Steven R. Jefferies