Abstract: Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system may assist a clinician in identifying one or more electrode combinations for sensing a brain signal. In another example, a user interface may display brain signal information and values of a stimulation parameter at least partially defining electrical stimulation delivered to a patient when the brain signal information was sensed.

Abstract: Certain aspects of the present disclosure provide techniques for detecting data errors. A method generally includes training each of a plurality of models on a plurality of training data sets to generate a set of trained models, determining a plurality of subsets of trained models from the set of trained models, for each respective subset: determining a plurality of ensemble outputs for the respective subset based on a plurality of validation data sets; and determining at least one evaluation metric for the respective subset based on the plurality of ensemble outputs; and determining an ensemble model as a subset of trained models having a best evaluation metric among a plurality of evaluation metrics associated with the plurality of subsets, wherein each subset comprises a different selection of models from the set of trained model than each other subset of trained models in the plurality of subsets of trained models.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: A wand includes a hinge configured to pivotally connect first and second wand segments in an extended configuration and a storage configuration. A first locking mechanism locks the wand in extended configuration. A second locking mechanism includes a rod, a sliding lever, a plunger, and a plunger cavity. The plunger is configured to be received in the plunger cavity to lock the wand in the storage configuration. When in the extended configuration, depressing a single actuator pivots the locking arm, causes the hook/pawl to be removed from the locking cavity, and unlocks the wand. When in the storage configuration, depressing the single actuator causes the rod to move in a first direction, causes the sliding rod to move a second direction, and urges the plunger out of the plunger cavity.

Abstract: An automated plate shaping and verification system allows for the accurate and efficient transformation of a metal plate from a starting shape to a target shape. Using a method for path planning, the system can select heating patterns based on modeling the expected deformation of a particular material type and thickness and identifying candidate heating paths that will sufficiently cause the plate to transform towards the target shape.

Abstract: A method of transporting a vehicle engine wire harness from a component preparation location to a component pick location is provided. The method includes placing the vehicle engine wire harness on a hook of a component hanger. The component hanger with vehicle engine wire harness is directed along a supply track assembly through a heated enclosure to the component pick location at a vehicle assembly line.

Abstract: A method of transporting a vehicle engine wire harness from a component preparation location to a component pick location is provided. The method includes placing the vehicle engine wire harness on a hook of a component hanger. The component hanger with vehicle engine wire harness is directed along a supply track assembly through a heated enclosure to the component pick location at a vehicle assembly line.

Abstract: Embodiments of the present disclosure relate to simulation, generally, and in some embodiments, more specifically to simulating a flight path of a golf ball. In such embodiments, a computer may be adapted to determine a first trajectory of the golf ball based on one linear expression; determine variations based on a flight path of the golf ball according to a first plane and a second plane, the first plane and second plane having orthogonality; adjust the first trajectory based on the variations; and provide a virtual golf ball with a virtual flight path based on the adjusted trajectory.

Abstract: Embodiments of the present disclosure relate to simulation, generally, and in some embodiments, more specifically to simulating a flight path of a golf ball. In such embodiments, a computer may be adapted to determine a first trajectory of the golf ball based on one linear expression; determine variations based on a flight path of the golf ball according to a first plane and a second plane, the first plane and second plane having orthogonality; adjust the first trajectory based on the variations; and provide a virtual golf ball with a virtual flight path based on the adjusted trajectory.

Abstract: A wireless testing device includes a trailer connector portion including a plurality of inputs; a communication device; a plurality of loads each connected to one of the plurality of inputs; and a control device. The plurality of inputs is configured to connect to a plurality of circuits in a vehicle. The control device is configured to determine the operability of each of the plurality of circuits in the vehicle when the trailer connector portion is connected to the vehicle by applying each of the plurality of loads to one of the plurality of inputs.

Abstract: A wireless testing device includes a trailer connector portion including a plurality of inputs; a communication device; a plurality of loads each connected to one of the plurality of inputs; and a control device. The plurality of inputs is configured to connect to a plurality of circuits in a vehicle. The control device is configured to determine the operability of each of the plurality of circuits in the vehicle when the trailer connector portion is connected to the vehicle by applying each of the plurality of loads to one of the plurality of inputs.

Abstract: A method for detecting acute ischemia is disclosed. The method comprises the steps of determining ST segment deviations and storing the results in heart rate based histograms. The histogram data is periodically analyzed to estimate a true range of ST deviation for a particular heart rate range. A current threshold for a heart rate range is set by estimating the true range of ST deviations within that bin, determining the median value of ST deviations within the range, and basing thresholds on the range and median value. The true range for a particular heart rate bin is estimated by locating ST deviation values between which reside a predetermined percentage of all ST deviation values collected for that bin.

Abstract: A system for detecting cardiac events and alerting the patient of the cardiac event issued by an implanted medical device. A processor detects a cardiac event and issues an activation signal to a patient alerting mechanism which emits an alarm during a first time interval followed by an alarm-off period of time. Reminder alarms are issued periodically following the alarm-off period of time. Reminder alarms are issued during reminder on-periods of time which are shorter than the first time interval. The alarm-off period and the time between periodic reminder alarms are greater than the alarm first time interval. A disabling device permits disabling of reminder alarms.

Abstract: A heart monitor is disclosed. The monitor computes ST segment deviations and stores the results in heart rate based histograms. Periodically, the monitor analyzes the histogram data to determine a normal range of ST deviation for a particular heart rate range. The monitor computes heart rate dependent ischemia detection thresholds based on the upper and lower boundaries of the normal range. A current threshold for a heart rate range is set as a weighted average of the prior threshold and a provisional threshold based on recent data, thereby limiting the amount the actual detection threshold changes from period to period.

Abstract: A heart monitor is disclosed. The monitor computes ST segment deviations and stores the results in heart rate based histograms. Periodically, the monitor analyzes the histogram data to determine heart rate dependent acute ischemia detection thresholds. If the statistical distribution associated with a heart rate range is insufficient, the threshold for that heart rate range is set as a function of the threshold for a neighboring heart rate range. Thresholds are also increased for heart rate ranges associated with statistical distributions that are sufficient but that have a relatively small number of entries.

Abstract: A method for tracking cardiac conditions is disclosed. An electrical signal from a patient's heart is sensed. A heart signal parameter value and an associated heart rate value are computed from the electrical signal. Based on the heart rate value, one of a plurality of histograms stored in a histogram memory is updated with the heart signal parameter value. After a data collection time period has elapsed, a statistical value of the heart signal parameter is computed from the selected histogram. A detection threshold for abnormal values of the heart signal parameter is then computed based on the statistical value.

Abstract: Disclosed is a system for the detection of cardiac events that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using different algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means) which are activated after the ST segment of the electrogram exceeds a preset threshold.

Abstract: A heart monitor is disclosed. The monitor computes ST segment deviations and stores the results in heart rate based histograms. Periodically, the monitor analyzes the histogram data to determine a normal range of ST deviation for a particular heart rate range. The monitor computes heart rate dependent ischemia detection thresholds based on the upper and lower boundaries of the normal range.

Abstract: Disclosed is a system for the detection of cardiac events that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using different algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means) which are activated after the ST segment of the electrogram exceeds a preset threshold.

Abstract: A heart monitor computes ST segment deviation as the difference in the value of an electrocardiogram signal at the ST and PQ points of a heartbeat. The ST point is found based on slope criteria and temporal criteria. The maximum (positive) slope of the QRS (maxQRS) is located. Within a preset window after the maxQRS point, the processor searches for a sample at which the second finite difference is less than a threshold that is a function of average QRS amplitude. If such a qualifying sample is found, the processor examines its location relative to the location of an adaptive window that is centered on a sample that is an adaptively determined distance from the peak of the R wave. If the qualifying point is within the adaptive window, it is chosen as the ST point. If the qualifying point is after the adaptive window, the ST point is set at the end of the adaptive window. Finally, if the qualifying point is before the adaptive window, the ST point is selected at the beginning of the adaptive window.