Patents by Inventor Steven R. Lammert

Steven R. Lammert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of 4-haloazetidin-2-ones from 4-sulfinoazetidin-2-ones
    Patent number: 4368156
    Abstract: Process for 4-halo azetidinones of the formula ##STR1## wherein R.sub.1 is acylamino or diacylamino, X is chloro, bromo or iodo, and R is a carboxy-protecting group which comprises treating a 4-sulfinoazetidinone of the formula ##STR2## with positive halogen reagent, eg. N-chlorosuccinimide, N-bromosuccinimide, N-iodosuccinimide, hypohalite. The 4-haloazetidinones are useful intermediate for .beta.-lactam antibiotics.
    Type: Grant
    Filed: March 9, 1981
    Date of Patent: January 11, 1983
    Assignee: Eli Lilly and Company
    Inventors: Wayne A. Spitzer, Stjepan Kukolja, Theodore Goodson, Jr., Steven R. Lammert
  • Process for cleaving an imido side chain from penicillins and cephalosporins
    Patent number: 4005074
    Abstract: The amic acid group of a 7-(amic acid) cephalosporin or 6-(amic acid) penicillin is cleaved by dehydration to the corresponding novel 7-isoimidocephalosporin or 6-isoimido-penicillin, and cleavage of the 7-isoimidocephalosporin or 6-isoimidopenicillin to the corresponding 7-aminocephalosporin or 6-aminopenicillin or to a corresponding 7-acylamidocephalosporin or 6-acylamidopenicillin.
    Type: Grant
    Filed: June 18, 1973
    Date of Patent: January 25, 1977
    Assignee: Eli Lilly and Company
    Inventors: Stjepan P. Kukolja, Steven R. Lammert
  • Cephalosporin cleavage process
    Patent number: 4001239
    Abstract: A 7-(amic acid) cephalosporin is cleaved by conversion to the corresponding mixed anhydride and cleavage of the mixed anhydride to the corresponding 7-aminocephalosporin or to a corresponding 7-acylamidocephalosporin.
    Type: Grant
    Filed: June 13, 1975
    Date of Patent: January 4, 1977
    Assignee: Eli Lilly and Company
    Inventors: Stjepan P. Kukolja, Steven R. Lammert
  • Cephalosporin cleavage process
    Patent number: 3994888
    Abstract: A 7-(amic acid) cephalosporin is cleaved by conversion to the corresponding mixed anhydride and cleavage of the mixed anhydride to the corresponding 7-aminocephalosporin or to a corresponding 7-acylamidocephalosporin.
    Type: Grant
    Filed: June 13, 1975
    Date of Patent: November 30, 1976
    Assignee: Eli Lilly and Company
    Inventors: Stjepan P. Kukolja, Steven R. Lammert
  • Process for preparing a desacetoxycephalosporin from a penam and/or a cepham compound
    Patent number: 3968108
    Abstract: A 3.alpha.-methyl-3.beta.-halocepham compound and/or a 2.alpha.-methyl-2.beta.-halomethylpenam compound is converted to a mixture comprising a 3-methyl-3-cephem (desacetoxycephalosporin), a 3.alpha.-methyl-3.beta.-acyloxycepham, and a 2.alpha.-methyl-2.beta.-acyloxymethylpenam by reaction of said 3-halocepham compound and/or said 2-halomethylpenam compound with a silver salt of a lower alkyl carboxylic acid or a cycloalkyl carboxylic acid.
    Type: Grant
    Filed: March 27, 1974
    Date of Patent: July 6, 1976
    Assignee: Eli Lilly and Company
    Inventors: Stjepan P. Kukolja, Steven R. Lammert
  • 3-Nitrooxycepham compounds and process for preparing desacetoxycephalosporins therefrom
    Patent number: 3962226
    Abstract: A 3.alpha.-methyl-3.beta.-halocepham compound and/or a 2.alpha.-methyl-2.beta.-halomethylpenam compound is converted to a mixture comprising a 3-methyl-3-cephem (desacetoxycephalosporin), a 3.alpha. -methyl-3.beta.-nitrooxycepham, and a 2.alpha.-methyl-2.beta.-nitrooxymethylpenam by reaction of said halocepham compound and/or said halomethylpenam compound with silver nitrate. The novel 3-nitrooxycepham compound upon heating is converted to a desacetoxycephalosporin.
    Type: Grant
    Filed: March 27, 1974
    Date of Patent: June 8, 1976
    Assignee: Eli Lilly and Company
    Inventors: Stjepan P. Kukolja, Steven R. Lammert
  • Preparation of desacetoxy-cephalosporin sulfoxides from penicillin sulfoxides
    Patent number: 3960851
    Abstract: A penicillin sulfoxide ester is reacted with sulfuryl chloride at a temperature of from about 75.degree.C. to about 120.degree.C. to produce a novel 2-chlorosulfinyl-azetidin-4-one intermediate, which intermediate is treated with an alkaline reagent to produce a desaceetoxycephalosporin sulfoxide.
    Type: Grant
    Filed: July 11, 1974
    Date of Patent: June 1, 1976
    Assignee: Eli Lilly and Company
    Inventors: Stjephan P. Kukolja, Steven R. Lammert
  • Preparation of 6-acylamino-2-methyl-2-halomethyl penams
    Patent number: 3960844
    Abstract: A 7-acylamino-3-hydroxy-3-methylcepham-4-carboxylic acid ester is reacted with a mixture of a halogenating agent and a tertiary carboxamide to produce a 2-halomethylpenam compound, a useful intermediate for the preparation of desacetoxycephalosporins.
    Type: Grant
    Filed: February 11, 1975
    Date of Patent: June 1, 1976
    Assignee: Eli Lilly and Company
    Inventors: Stjepan Kukolja, Steven R. Lammert
  • Process for the conversion of 3-methyl-3-hydroxycepham compounds
    Patent number: 3932387
    Abstract: A 7-imido-3-methyl-3-hydroxycepham-4-carboxylic acid ester is reacted with a halogen reagent in the presence of an alkaline reagent to produce 2-halomethylpenams and a 3-methyl-3-cephem compound.
    Type: Grant
    Filed: March 27, 1974
    Date of Patent: January 13, 1976
    Assignee: Eli Lilly and Company
    Inventors: Stjepan P. Kukolja, Steven R. Lammert