Patents by Inventor Steven R. Wiley

Steven R. Wiley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7482430
    Abstract: The present invention provides methods and compositions relating to fusion proteins comprising multimeric soluble TWEAK receptor fragments and an oligomerization domain. Such fusion proteins are useful for antagonizing the TWEAK receptor and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and inflammatory conditions.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: January 27, 2009
    Assignee: Amgen Inc.
    Inventor: Steven R. Wiley
  • Publication number: 20080254506
    Abstract: This invention relates to new members of the human Claudin polypeptide family, to methods of making such polypeptides, and to methods of using them to treat Claudin-associated conditions and to identify compounds that alter Claudin polypeptide activities.
    Type: Application
    Filed: February 1, 2007
    Publication date: October 16, 2008
    Applicant: Immunex Corpotation
    Inventors: Adel Youakim, Robert F. DuBose, Steven R. Wiley
  • Patent number: 7319535
    Abstract: An imaging system includes an authorization logic that authenticates a imaging request. The system determines whether the imaging request includes a code that matches an access code that is displayed by an imaging device in the system. If there is a match, the imaging request is processed.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: January 15, 2008
    Assignee: Hewlett-Packard Development Company,
    Inventors: Darrel Cherry, James Clough, Steven R. Wiley
  • Patent number: 7186802
    Abstract: This invention relates to new members of the human Claudin polypeptide family, to methods of making such polypeptides, and to methods of using them to treat Claudin-associated conditions and to identify compounds that alter Claudin polypeptide activities.
    Type: Grant
    Filed: August 15, 2001
    Date of Patent: March 6, 2007
    Assignee: Immunex Corporation
    Inventors: Adel Youakim, Robert F. DuBose, Steven R. Wiley
  • Patent number: 7132264
    Abstract: This invention relates to Thypin, a new member of the human serpin polypeptide family, methods of making Thypin polypeptides and using these polypeptides to treat various medical disorders and to methods of screening for compounds that agonize or antagonize Thypin polypeptide activities.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: November 7, 2006
    Assignee: Immunex Corporation
    Inventors: Howard R. G. Clarke, Robert F. DuBose, Steven R. Wiley
  • Patent number: 6958387
    Abstract: This invention relates to Thypin, a new member of the human serpin polypeptide family, methods of making Thypin polypeptides and using these polypeptides to treat various medical disorders and to methods of screening for compounds that agonize or antagonize Thypin polypeptide activities.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: October 25, 2005
    Assignee: Immunex Corporation
    Inventors: Howard R. G. Clarke, Robert F. DuBose, Steven R. Wiley
  • Publication number: 20040253610
    Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
    Type: Application
    Filed: January 8, 2004
    Publication date: December 16, 2004
    Applicant: Immunex Corporation
    Inventor: Steven R. Wiley
  • Patent number: 6824773
    Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
    Type: Grant
    Filed: December 19, 2000
    Date of Patent: November 30, 2004
    Assignee: Immunex Corporation
    Inventor: Steven R. Wiley
  • Publication number: 20040152161
    Abstract: This invention relates to human and murine HPR1 and human and murine HPR2 polypeptides, new members of the hematopoietin receptor polypeptide family; to methods of making such HPR1 and HPR2 polypeptides; to non-human mammals in which the endogenous genomic sequences encoding HPR1 and/or HPR2 polypeptides have been partially or completely inactivated; to methods of using HPR1 or HPR2 polypeptides to identify compounds that alter HPR1 or HPR2 polypeptide activities; and to methods of preparing medicaments for and/or treating conditions associated with hematopoietin receptor function.
    Type: Application
    Filed: November 14, 2003
    Publication date: August 5, 2004
    Applicant: Immunex Corporation
    Inventors: David J. Cosman, Bruce A. Mosley, Robert F. DuBose, Steven R. Wiley
  • Publication number: 20040114175
    Abstract: An imaging system includes an authorization logic that authenticates a imaging request. The system determines whether the imaging request includes a code that matches an access code that is displayed by an imaging device in the system. If there is a match, the imaging request is processed.
    Type: Application
    Filed: December 17, 2002
    Publication date: June 17, 2004
    Inventors: Darrel Cherry, James Clough, Steven R. Wiley
  • Publication number: 20040091473
    Abstract: Provided is a new disintegrin polypeptide, methods of making such polypeptides, and methods of using them to treat disintegrin-associated disorders and conditions and to identify agents that modulate Metalloproteinase-Disintegrin polypeptide activities.
    Type: Application
    Filed: June 17, 2003
    Publication date: May 13, 2004
    Inventors: Robert F. DuBose, Steven R. Wiley, Roy A. Black
  • Patent number: 6727225
    Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: April 27, 2004
    Assignee: Immunex Corporation
    Inventor: Steven R. Wiley
  • Publication number: 20040052788
    Abstract: A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.
    Type: Application
    Filed: September 2, 2003
    Publication date: March 18, 2004
    Applicant: IMMUNEX CORPORATION
    Inventors: Steven R. Wiley, Raymond G. Goodwin
  • Publication number: 20040047854
    Abstract: Provided is a new disintegrin polypeptide, methods of making such polypeptides, and methods of using them to treat disintegrin-associated disorders and conditions and to identify agents that modulate Metalloproteinase-Disintegrin polypeptide activities.
    Type: Application
    Filed: June 10, 2003
    Publication date: March 11, 2004
    Inventors: Roy A. Black, Kurt M. Poindexter, Bruce A. Mosley, Robert F. DuBose, Steven R. Wiley
  • Publication number: 20040038370
    Abstract: This invention relates to new members of the human Claudin polypeptide family, to methods of making such polypeptides, and to methods of using them to treat Claudin-associated conditions and to identify compounds that alter Claudin polypeptide activities.
    Type: Application
    Filed: June 27, 2003
    Publication date: February 26, 2004
    Inventors: Adel Youakim, Robert F. DuBose, Steven R. Wiley
  • Publication number: 20030211509
    Abstract: An isolated clone consisting of sequences transcribed from the TNF-delta gene is disclosed. Also provided are human polypeptides translated from said TNF-delta sequences and a procedure for producing such polypeptide by recombinant techniques. Also provided are a procedure for producing soluble biologically active TNF-delta, which may be used to treat deficiencies of TNF-delta and diseases conditions ameliorated by TNF-delta. Antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat TNF-delta associated diseases, tumors or metastastases are disclosed. Also disclosed is the use of said antibodies, agonists and inhibitors as well as the nucleic acid sequences to screen for, diagnose, prognosticate, stage and monitor conditions and diseases attributable to TNF-delta, especially inflammation.
    Type: Application
    Filed: October 24, 2002
    Publication date: November 13, 2003
    Inventor: Steven R. Wiley
  • Publication number: 20030180275
    Abstract: This invention relates to Thypin, a new member of the human serpin polypeptide family, methods of making Thypin polypeptides and using these polypeptides to treat various medical disorders and to methods of screening for compounds that agonize or antagonize Thypin polypeptide activities.
    Type: Application
    Filed: March 8, 2002
    Publication date: September 25, 2003
    Inventors: Howard R.G. Clarke, Robert F. DuBose, Steven R. Wiley
  • Publication number: 20030180309
    Abstract: This invention relates to B7-H1.2 and Butryophilin 2/3, new members of the human B7 polypeptide family, methods of making such polypeptides, and to methods of using them to treat immunological conditions and to identify compounds that alter the activities of these human B7 polypeptides.
    Type: Application
    Filed: January 7, 2002
    Publication date: September 25, 2003
    Inventors: Peter R. Baum, Robert F. DuBose, Steven R. Wiley
  • Publication number: 20030059871
    Abstract: This invention relates to human and murine HPR1 and human and murine HPR2 polypeptides, new members of the hematopoietin receptor polypeptide family; to methods of making such HPR1 and HPR2 polypeptides; to non-human mammals in which the endogenous genomic sequences encoding HPR1 and/or HPR2 polypeptides have been partially or completely inactivated; to methods of using HPR1 or HPR2 polypeptides to identify compounds that alter HPR1 or HPR2 polypeptide activities; and to methods of preparing medicaments for and/or treating conditions associated with hematopoietin receptor function.
    Type: Application
    Filed: October 5, 2001
    Publication date: March 27, 2003
    Inventors: David J. Cosman, Bruce A. Mosley, Timothy A. Bird, Robert F. DuBose, Steven R. Wiley
  • Patent number: 6521228
    Abstract: A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.
    Type: Grant
    Filed: April 2, 2001
    Date of Patent: February 18, 2003
    Assignee: Immunex Corporation
    Inventors: Steven R. Wiley, Raymond G. Goodwin