Abstract: The present invention is directed to a method for producing commercial quantities of baculovirus using a combination of methods involving producing occlusion bodies with infectious baculovirus in caterpillar larvae and large numbers of viral particles with serial passages in cell culture. A two step method was developed by initially producing infectious virus in caterpillar larvae and then using the resultant infectious virus as an inoculum for a limited number of serial passages in cell culture so to produce large amounts of infectious baculovirus.

Abstract: A system for steering the direction of a borehole advanced by cutting action of a rotary drill bit by periodically varying the rotation speed of the drill bit. The steering system comprises a motor disposed in a bent housing subsection and operationally connected to a drill string and to the drill bit. The rotation speed of the drill bit is periodically varied by periodic varying the rotation speed of the motor or by periodic varying the rotation speed of the drill string. Periodic bit speed rotation results in preferential cutting of material from a predetermined arc of the borehole wall which, in turn, resulting in borehole deviation. Both the drill string and the drill motor are rotated simultaneously during straight and deviated borehole drilling.

Abstract: A polishing machine for optical elements, includes: a spindle arranged to rotationally drive an optical element; a polishing tool mobile relative to the spindle; a front face provided with a door enabling the access to the spindle and to the polishing tool; wherein the polishing tool is mounted on a body which is rotationally mounted on sliding elements by way of a first axis, the sliding elements being substantially perpendicular to the front face.

Abstract: A polishing machine for optical elements, comprising: a spindle arranged to rotationally drive an optical element; a polishing tool mobile relative to the spindle; wherein the polishing machine further comprises a platform mounted on top of a work chamber, the work chamber comprising the spindle, and the platform holding a body on which is mounted the polishing tool.

Abstract: The present invention is directed to a method for producing commercial quantities of Baculovirus using a combination of methods involving producing occlusion bodies with infectious baculovirus in caterpillar larvae and large numbers of viral particles with serial passages in cell culture. A two step method was developed by initially producing infectious virus in caterpillar larvae and then using the resultant infectious virus as an inoculum for a limited number of serial passages in cell culture so to produce large amounts of infectious baculovirus.

Abstract: The present invention features methods and compositions for treating a patient who has a neurological deficit. The method can be carried out, for example, by contacting (in vivo or in culture) a neural progenitor cell of the patient's central nervous system (CNS) with a polypeptide that binds the epidermal growth factor (EGF) receptor and directing progeny of the proliferating progenitor cells to migrate en masse to a region of the CNS in which they will reside and function in a manner sufficient to reduce the neurological deficit. The method may include a further step in which the progeny of the neural precursor cells are contacted with a compound that stimulates differentiation.

Abstract: The invention provides compositions and methods for attracting glial and neuronal progenitor cells and their progeny to desired sites within the central nervous system tissue. These compositions and methods can also be used to induce directed differentiation of these cells. By providing various ways to generate new glial and neuronal cells from endogenous progenitor cells, the invention also provides methods for inducing regeneration of tissues and neurological function, and, indeed, generating new phenotypes and capabilities. Thus, the invention features methods and compositions for ameliorating neurological deficits, including inherited disorders, trauma, infections and the like.