Abstract: Methods of improving motor function in subjects diagnosed with a central nervous system injury are contemplated as including an administration of a psychedelic, empathogenic, or dissociative compound in a pharmaceutically effective amount followed by administration of a motor skill restoration therapy. The psychedelic, empathogenic, or dissociative compound may be administered to a subject that has been determined to be therapy refractive with a chronic central nervous system injury, to a subject with a subacute central nervous system injury sustained within 7 days and 6 months prior, or to a subject with an acute central nervous system injury sustained within the past 7 days. Such methods may be seen improve motor function in the subjects.