Patents by Inventor Steven Ronkin

Steven Ronkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of IMPDH enzyme
    Patent number: 7087642
    Abstract: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: August 8, 2006
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Stamos, Martin Trudeau, Scott Bethiel, Steven Ronkin, Michael Badia, Jeffrey Saunders
  • Gyrase inhibitors and uses thereof
    Publication number: 20060122196
    Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
    Type: Application
    Filed: October 21, 2004
    Publication date: June 8, 2006
    Inventors: Paul Charifson, David Deininger, Anne-Laure Grillot, Yusheng Liao, Steven Ronkin, Dean Stamos, Emanuele Perola, Tiansheng Wang, Arnaud LeTiran, Joseph Drumm
  • Gyrase inhibitors and uses thereof
    Publication number: 20060025424
    Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
    Type: Application
    Filed: October 21, 2004
    Publication date: February 2, 2006
    Inventors: Paul Charifson, David Deininger, Anne-Laure Grillot, Yusheng Liao, Steven Ronkin, Dean Stamos, Emanuele Perola, Tiansheng Wang, Arnaud LeTiran, Joseph Drumm
  • Inhibitors of IMPDH enzyme
    Publication number: 20050282876
    Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
    Type: Application
    Filed: July 29, 2005
    Publication date: December 22, 2005
    Inventors: David Armistead, Michael Badia, Guy Bemis, Randy Bethiel, Catharine Frank, Perry Novak, Steven Ronkin, Jeffrey Saunders
  • Gyrase inhibitors and uses thereof
    Publication number: 20050256136
    Abstract: The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods of using compounds of formula I or formula VII in combination with one or more additional antibacterial agents and/or one or more additional therapeutic agents that increase the susceptibility of bacterial organisms to antibiotics.
    Type: Application
    Filed: November 11, 2004
    Publication date: November 17, 2005
    Inventors: Paul Charifson, David Deininger, Anne-Laure Grillot, Yusheng Liao, Steven Ronkin, Dean Stamos, Emanuele Perola, Tiansheng Wang, Arnaud LeTiran, Joseph Drumm
  • Gyrase inhibitors and uses thereof
    Patent number: 6930116
    Abstract: The present invention relates to compounds of the formula I: where Ring A is a thiazole, oxazole, imidazole or pyrazole and the substituents are as described in the specification, and pharmaceutically acceptable salts thereof. The compounds inhibit bacterial gyrase activity and therefore are useful for treating bacterial infections in mammals.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: August 16, 2005
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Paul Charifson, Dean Stamos, Michael Badia, Anne Laure Grillot, Steven Ronkin, Martin Trudeau
  • Inhibitors of IMPDH enzyme
    Publication number: 20050148644
    Abstract: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
    Type: Application
    Filed: November 24, 2004
    Publication date: July 7, 2005
    Inventors: Dean Stamos, Martin Trudeau, Randy Bethiel, Steven Ronkin, Michael Badia, Jeffrey Saunders
  • Gyrase inhibitors and uses thereof
    Publication number: 20050038247
    Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
    Type: Application
    Filed: July 29, 2004
    Publication date: February 17, 2005
    Inventors: Paul Charifson, David Deininger, Anne-Laure Grillot, Yusheng Liao, Steven Ronkin, Dean Stamos, Emanuele Perola, Tiansheng Wang, Arnaud LeTiran, Joseph Drumm
  • Inhibitors of IMPDH enzyme
    Publication number: 20040029939
    Abstract: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
    Type: Application
    Filed: November 4, 2002
    Publication date: February 12, 2004
    Inventors: Dean Stamos, Martin Trudeau, Scott Bethiel, Steven Ronkin, Michael Badia, Jeffrey Saunders
  • Gyrase inhibitors and uses thereof
    Publication number: 20040024030
    Abstract: The present invention relates to compounds of the formula I: 1
    Type: Application
    Filed: March 24, 2003
    Publication date: February 5, 2004
    Inventors: Paul Charifson, Dean Stamos, Michael Badia, Anne Laure Grillot, Steven Ronkin, Martin Trudeau
  • Gyrase inhibitors and uses thereof
    Publication number: 20030170858
    Abstract: Disclosed herein are compounds comprising the pharmacophore features HBA, HBD, Grp1, and at least two features selected from Grp2, Grp3 or Grp4: 1
    Type: Application
    Filed: July 18, 2002
    Publication date: September 11, 2003
    Inventors: Paul Charifson, Steve Bellon, Dean Stamos, Michael Badia, Anne-Laure Grillot, Steven Ronkin, Mark Murcko, Martin Trudeau
  • Gyrase inhibitors and uses thereof
    Patent number: 6608087
    Abstract: The present invention relates to compounds of the formula I: where Ring A is a thiazole, oxazole, imidazole or pyrazole and the substituents are as described in the specification, and pharmaceutically acceptable salts thereof. The compounds inhibit bacterial gyrase activity and therefore are useful for treating bacterial infections in mammals.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: August 19, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Paul Charifson, Dean Stamos, Michael Badia, Anne-Laure Grillot, Steven Ronkin, Martin Trudeau
  • Inhibitors of IMPDH enzyme
    Patent number: 6498178
    Abstract: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: December 24, 2002
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Stamos, Martin Trudeau, Scott Bethiel, Steven Ronkin, Michael Badia, Jeffrey Saunders
  • Inhibitors of IMPDH enzyme
    Publication number: 20020111378
    Abstract: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
    Type: Application
    Filed: September 19, 2001
    Publication date: August 15, 2002
    Inventors: Dean Stamos, Martin Trudeau, Scott Bethiel, Steven Ronkin, Michael Badia, Jeffrey Saunders