Abstract: Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase IX with minimum non-specific organ uptake are disclosed. Methods of imaging and/or treating carbonic anhydrase IX-expressing cells or tumors also are disclosed.

Abstract: The present disclosure provides compositions and methods for treating and/preventing diseases and conditions associated with premature termination mutations. The methods disclosed herein comprise the step of administering to the subject a therapeutically effective dose of a compound described herein that induces read-through of the premature termination codon. The methods of the present disclosure may further comprise treating the subject with enzyme replacement therapy wherein the enzyme replacement therapy is selected for the disease or condition to be treated. Furthermore, the present disclosure provides method of pharmacologically suppressing premature termination codons in a subject in need of such suppression.

Abstract: Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase IX with minimum non-specific organ uptake are disclosed. Methods of imaging and/or treating carbonic anhydrase IX-expressing cells or tumors also are disclosed.

Abstract: Autonomous vehicles are capable of executing missions that abide by on-street rules or regulations, while also being able to seamlessly transition to and from “zones,” including off-street zones, with their our set(s) of rules or regulations. An on-board memory stores roadgraph information. An on-board computer is operative to execute commanded driving missions using the roadgraph information, including missions with one or more zones, each zone being defined by a sub-roadgraph with its own set of zone-specific driving rules and parameters. A mission may be coordinated with one or more payload operations, including zone with “free drive paths” as in a warehouse facility with loading and unloading zones to pick up payloads and place them down, or zone staging or entry points to one or more points of payload acquisition or placement. The vehicle may be a warehousing vehicle such as a forklift.

Abstract: A new reactor apparatus that can be used to carry out chemical reactions in a fluidized catalyst bed at high temperatures with reduced afterburning or other undesirable downstream side reactions.

Abstract: A touchpad and supporting logic that provides absolute or relative positioning of a graphics cursor on a display. Absolute positioning is preferably invoked by touching the touchpad in a designated region. Relative positioning is preferably implemented by continual movement across a touchpad relative to a reference location. A method of achieving absolute and relative positioning is also disclosed.

Abstract: A touchpad and supporting logic that provides absolute or relative positioning of a graphics cursor on a display. Absolute positioning is preferably invoked by touching the touchpad in a designated region. Relative positioning is preferably implemented by continual movement across a touchpad relative to a reference location. A method of achieving absolute and relative positioning is also disclosed.

Abstract: A catheter includes a flexible elongated catheter body that defines a needle-receiving, or probe-receiving, lumen, a retractable tissue-penetrable needle, or probe, and an electrode mounted on the distal portion of the catheter body. The needle provides a fluid passage for introducing fluid into tissue to permit the introduction of sclerotic agents for enhancing electrocoagulation of the tissue, heat-responsive drugs for improving the bonding to tissue surfaces, or vaso-constrictor drugs. The probe can also have a passage for fluid. The electrode can provide bipolar electro-coagulation of tissue in combination with an additional electrode mounted on the catheter body, or alternatively, the electrode can be employed in combination with either the needle or probe to establish a bipolar electro-coagulation path through tissue. The needle, or probe, in combination with an external electrode can be used to provide unipolar electro-coagulation, or ablation.