Abstract: A recombinant, attenuated mumps virus is described. The recombinant virus is based on the genotype A Jeryl Lynn vaccine strain, but is modified to express genotype G consensus fusion (F) and hemagglutinin-neuraminidase (HN) proteins. The recombinant virus optionally includes a mutation that prevents expression of viral protein V. The recombinant mumps virus can be used as a vaccine to inhibit mumps virus infection and the development of mumps disease.

Abstract: The present invention provides the complete genomic sequence of the epidemic mumps virus (MuV) strain MuVIowa/US/06. Further, a reverse genetics system was constructed and used to rescue recombinant viral constructs that are attenuated compared to rMuVIowa/US/06 and JL vaccine viruses. Such constructs include viral constructs lacking the open reading frame (ORF) of the SH gene (rMuV?SH) and/or incapable of expressing the V protein (rMuV?V).

Abstract: The present invention provides the complete genomic sequence of the epidemic mumps virus (MuV) strain MuVIowa/US/06. Further, a reverse genetics system was constructed and used to rescue recombinant viral constructs that are attenuated compared to rMuVIowa/US/06 and JL vaccine viruses. Such constructs include viral constructs lacking the open reading frame (ORF) of the SH gene (rMuV?SH) and/or incapable of expressing the V protein (rMuV?V).

Abstract: The invention provides methods of treating viral encephalitis in a patient. Such methods entail administering to the patient an effect amount of an agent that inhibits binding of leukocytes to brain endothelial cells via leukocyte surface antigen alpha-4 integrin. Such agents include antibodies and small molecules that specially bind to alpha-4 integrin.

Abstract: Implantable defibrillators are implanted into the chests of patients prone to suffering ventricular fibrillation, a potentially fatal heart condition. Critical components in these devices are aluminum electrolytic capacitors, which store and deliver one or more life-saving bursts of electric charge to a fibrillating heart. These capacitors make up about one third the total size of the defibrillators. Unfortunately, manufacturers of these capacitors have paid little or no attention to reducing the size of these capacitors through improved capacitor packaging. Accordingly, the inventors devised a unique capacitor lid, or header, assembly that allows size reduction. Specifically, one embodiment of the header assembly includes two recesses, each with a depth that allows the head of a rivet (or other fastener) to be substantially flush, or coplanar, with the underside of the header. Another embodiment includes a single recess to receive two rivet heads.

Abstract: An acne treatment regimen includes: cleansing the skin of an individual afflicted with acne with an acne cleanser composition containing an anti-acne active; applying an acne spot treating composition to at least one lesion on the skin of the individual, the acne spot treating composition containing an anti-acne active ingredient; applying a hydrating day cream composition to the skin of the individual, the hydrating day cream composition containing an anti-acne active ingredient and a combination of farnesol and sodium hyaluronate; and applying an acne night cream composition to the skin of the individual, the acne night cream composition containing an anti-acne active ingredient and a combination of famesol and sodium hyaluronate.

Abstract: Implantable defibrillators are implanted into the chests of patients prone to suffering ventricular fibrillation, a potentially fatal heart condition. Critical components in these devices are aluminum electrolytic capacitors, which store and deliver one or more life-saving bursts of electric charge to a fibrillating heart. These capacitors make up about one third the total size of the defibrillators. Unfortunately, manufacturers of these capacitors have paid little or no attention to reducing the size of these capacitors through improved capacitor packaging. Accordingly, the inventors devised a unique capacitor lid, or header, assembly that allows size reduction. Specifically, one embodiment of the header assembly includes two recesses, each with a depth that allows the head of a rivet (or other fastener) to be substantially flush, or coplanar, with the underside of the header. Another embodiment includes a single recess to receive two rivet heads.

Abstract: Implantable defibrillators are implanted into the chests of patients prone to suffering ventricular fibrillation, a potentially fatal heart condition. Critical components in these devices are aluminum electrolytic capacitors, which store and deliver one or more life-saving bursts of electric charge to a fibrillating heart. These capacitors make up about one third the total size of the defibrillators. Unfortunately, manufacturers of these capacitors have paid little or no attention to reducing the size of these capacitors through improved capacitor packaging. Accordingly, the inventors devised a unique capacitor lid, or header, assembly that allows size reduction. Specifically, one embodiment of the header assembly includes two recesses, each with a depth that allows the head of a rivet (or other fastener) to be substantially flush, or coplanar, with the underside of the header. Another embodiment includes a single recess to receive two rivet heads.

Abstract: A substrate is coated with a first material which is soluble in a first solvent, whereupon a second material which is strongly adherent to the first material and insoluble in the first solvent is selectively applied by an ink jet printer. The substrate is then developed in the first solvent to establish the image. In a preferred embodiment the substrate is hydrophilic, the first material is a negative working photosensitive material, and the second material is a transparent adhesive, which permits curing the first material by exposure to actinic light after the development step. The adhesive is then removed. In an embodiment directed to a waterless plate the substrate includes a surface coating of silicone, and the first material is a primer which promotes adhesion of a second material in the form of an oleophilic adhesive which is selectively applied. The primer is then developed to expose the silicone on the non-image areas.

Abstract: A capacitor cover for closing an open end of a capacitor, including an elastomeric outer layer, a rigid middle layer and a polypropylene inner layer, each with an aperture so as to allow passage of a terminal through the capacitor cover, is described. The inner layer has a peripheral skirt and an annular skirt which extend outwardly sufficiently to prevent electrolyte from the capacitor from coming into contact with the peripheral surface and the annular surface of the rigid middle layer. The capacitor cover can result in the capacitor achieving a temperature tolerance of at least about 105.degree. C. An electrolytic capacitor, including a capacitor body, an electrolyte and a capacitor cover is also described.

Abstract: A substrate is coated with a first material which is soluble in a first solvent, whereupon a second material which is strongly adherent to the first material and insoluble in the first solvent is selectively applied by an ink jet printer. The substrate is then developed in the first solvent to establish the image. In a preferred embodiment the substrate is hydrophilic, the first material is a negative working photosensitive material, and the second material is a transparent adhesive, which permits curing the first material by exposure to actinic light after the development step. The adhesive is then removed. In an embodiment directed to a waterless plate the substrate includes a surface coating of silicone, and the first material is a primer which promotes adhesion of a second material in the form of an oleophilic adhesive which is selectively applied. The primer is then developed to expose the silicone on the non-image areas.

Abstract: A substrate is coated with a first material which is soluble in a first solvent, whereupon a second material which is strongly adherent to the first material and insoluble in the first solvent is selectively applied by an ink jet printer. The substrate is then developed in the first solvent to establish the image. In a preferred embodiment the substrate is hydrophilic, the first material is a negative working photosensitive material, and the second material is a transparent adhesive, which permits curing the first material by exposure to actinic light after the development step. The adhesive is then removed. In an embodiment directed to a waterless plate the substrate includes a surface coating of silicone, and the first material is a primer which promotes adhesion of a second material in the form of an oleophilic adhesive which is selectively applied. The primer is then developed to expose the silicone on the non-image areas.

Abstract: A substrate is coated with a first material which is soluble in a first solvent, whereupon a second material which is strongly adherent to the first material and insoluble in the first solvent is selectively applied by an ink jet printer. The substrate is then developed in the first solvent to establish the image. In a preferred embodiment the substrate is hydrophilic, the first material is a negative working photosensitive material, and the second material is a transparent adhesive, which permits curing the first material by exposure to actinic light after the development step. The adhesive is then removed. In an embodiment directed to a waterless plate the substrate includes a surface coating of silicone, and the first material is a primer which promotes adhesion of a second material in the form of an oleophilic adhesive which is selectively applied. The primer is then developed to expose the silicone on the non-image areas.

Abstract: A mounting ring is secured in the mouth end of a capacitor casing by being engaged under the rolled-over rim of the fully sealed capacitor.

Abstract: A mounting spacer (16) for use in an electrolytic capacitor (10) having a capacitance section (14) and a tubular casing (12), which locates and restrains the capacitance section within the casing. The mounting spacer (16) is a flexible plastic sheet which when folded fits inside and bears against the tubular casing (12). The spacer has a base section (34) with at least two living hinges (30, 32); the living hinges connect the base section to wedge sections (40, 42) and support arms (36, 38). The support arms have cutout sections (44,46) formed by the pivoting of wedge sections (40,42) which receive and longitudinally support the capacitance section during assembly of the capacitor. The support arms flex after insertion to partially wrap around and laterally support the capacitance section while maintaining contact with the casing. After assembly, the wedge sections are resiliently held in contact with the tubular casing by the resilient base section (34) to center the spacer.