Abstract: Described herein are endoscopic guide tube devices, systems and methods for using the guide tubes to facilitate insertion of an endoscope into a body cavity. The device may include a pressurization chamber having a nozzle, an everting tube mounted within the pressurization chamber, and a valve located at or proximate the distal end of the everting tube. The valve can be configured to open when the everting tube is fully deployed. A tether can be attached to the distal end of the everting tube to restrain the everting tube from fully deploying until a release mechanism is engaged. The valve can be formed from two sheets that are adjacent to each other and/or can include a viscous gel.

Abstract: A method in which photodynamic therapy is employed to inhibit, stabilize or reduce occlusions within the cardiovascular system by utilizing light within the spectral region of approximately 390 to approximately 610 nm.