Abstract: The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder. In some aspects, the composition may be presented in the form of an unoccluded or free form topically administered gel.

Abstract: One embodiment relates to a laser positioning device for sensing relative movement between a data input device and a surface by determining displacement of image features in a succession of images of the surface. The device forms a single integrated package, which includes a planar substrate and a transparent encapsulant that also embodies a collimating lens. Both a coherent light source and a sensor array and associated circuitry are configured on the planar substrate. Another embodiment relates to a method of sensing relative movement between a data input device and a surface. Coherent light is emitted from a laser and collimated so as to form a collimated illumination beam with a predetermined diameter, D, and a substantially uniform phase front. A speckle pattern is generated by impingement of the collimated illumination beam on the surface and detected by a sensor array. Other embodiments are also disclosed.

Abstract: One embodiment relates to an optical navigation device. The device includes a lead frame having reference features, a laser, a detector array, and an optical component having alignment features. The laser is attached to the lead frame and positioned in reference to the reference features of the lead frame. The detector array is attached to the lead frame and positioned in reference to the reference features of the lead frame. The optical component is coupled to the lead frame so that its alignment features register to the reference features of the lead frame. In this way, the molded optical component is passively aligned to the laser and the detector array. Other embodiments are also disclosed.

Abstract: A method of bonding two elements such as wafers used in microelectronics applications is disclosed. One inventive aspect relates to a method for bonding comprising producing on a first main surface of a first element a first solder ball, producing on a first main surface of a second element a second solder ball, providing contact between the first solder ball and the second solder ball, bonding the first element and the second element by applying a reflow act whereby the solder balls melt and form a joined solder ball structure. Prior to the bonding, the first solder ball is laterally embedded in a nonconductive material, such that the upper part of the first solder ball is not covered by the non-conductive material. Devices related to such methods are also disclosed.

Abstract: The present invention relates to coating compositions, particularly water-based coating compositions, which incorporate nanotechnology. More specifically, the water-based coating compositions may include: a binder; a plurality of hydrophobic silica particles; and a solvent. The coating compositions may be applied to a variety of different surfaces, such as, for example, metals, plastics and signs, among others to impart resistance to corrosion and/or deterioration over time, as well as good adhesion thereto.

Abstract: An office panel partition includes a panel frame having at least two uprights and a horizontal structural member rigidly interconnecting the uprights. The panel frame has a first side and a second opposite side, and the panel frame defines at least four apertures on the first side thereof. The partition also includes a cover member having a major planar surface defining an exterior surface of the partition. The cover member includes at least four projections that are removably insertable into the at least four apertures to removably secure the cover member to the frame. The apertures are arranged in at least two vertically spaced horizontal rows and at least two horizontally spaced vertical columns. The apertures in a first one of the columns have different horizontal dimensions than those of the apertures located in the other of the columns. Each of the projections has a range of lateral positions when inserted into a respective one of the apertures.

Abstract: The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder.

Abstract: The present application relates to a Raman amplifier having an increased dynamic range, and particularly for laser pump sources and a method of pumping Raman fiber amplifiers over a greater dynamic range. In a multi-channel optical system, optical amplifiers must be able to provide gains over a large dynamic range, which is determined by the distribution of node-to-node distances in the network, as well as the number of channels. The present invention has found that the dynamic range of a Raman amplifier can be significantly increased by using pulse width modulation to pulse pump current at or near the minimum current stability threshold, in order to produce lower power output. The duty cycle of the pulsed current is selected to achieve a time-averaged operating condition, thus the time averaged pump power can be reduced in a linear fashion well below the capability of a continuous wave system.

Abstract: A method of bonding two elements such as wafers used in microelectronics applications is disclosed. One inventive aspect relates to a method for bonding comprising producing on a first main surface of a first element a first solder ball, producing on a first main surface of a second element a second solder ball, providing contact between the first solder ball and the second solder ball, bonding the first element and the second element by applying a reflow act whereby the solder balls melt and form a joined solder ball structure. Prior to the bonding, the first solder ball is laterally embedded in a nonconductive material, such that the upper part of the first solder ball is not covered by the non-conductive material. Devices related to such methods are also disclosed.

Abstract: The invention relates to a method for automatic dynamic gain control in optical Raman amplifiers and an optical Raman amplifier adapted for the same. The present invention has found that in multiple pump Raman amplifiers a substantially linear relationship exists between total amplified signal power and pump power for each of different wavelength pumps, in order to maintain an original gain profile and gain levels for an optical link with a fully loaded channel configuration, in response to dropped channels. In accordance with the method, and an amplifier programmed to practice the method, a set of pump power values and signal level values required to maintain the characterized gain profile and gain levels for a plurality of channel loading configurations are pre-established for the each pump wavelength. A linear function from each set of pre-established values is derived for each pump wavelength.

Abstract: The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder. In some aspects, the composition may be presented in the form of an unoccluded or free form topically administered gel.

Abstract: A Lyot depolarizer for depolarizing a laser with multiple longitudinal modes comprises two segments of PM fiber optimized for length as a function of the longitudinal mode spacing of the laser source, and not as taught in the prior art as a function of the laser coherence length. The present invention has found secondary coherence peaks in the coherence function of a multiple longitudinal mode source, which can significantly worsen the DoP if the PM fiber lengths are significantly extended beyond optimum, contrary to the teaching in the prior art. The present invention makes use of the periodic structure of the source spectrum by converting half the longitudinal modes to an orthogonal polarization state. As a result a significantly shorter fiber depolarizer is needed than for a single longitudinal mode source. Greater temperature stability is achieved by properly adjusting the lengths of both segments of PM fiber.

Abstract: The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder.

Abstract: The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder.

Abstract: The invention relates to a method for automatic dynamic gain control in optical Raman amplifiers and an optical Raman amplifier adapted for the same. The present invention has found that in multiple pump Raman amplifiers a substantially linear relationship exists between total amplified signal power and pump power for each of different wavelength pumps, in order to maintain an original gain profile and gain levels for an optical link with a fully loaded channel configuration, in response to dropped channels. In accordance with the method, and an amplifier programmed to practice the method, a set of pump power values and signal level values required to maintain the characterized gain profile and gain levels for a plurality of channel loading configurations are pre-established for the each pump wavelength. A linear function from each set of pre-established values is derived for each pump wavelength.

Abstract: The present application relates to a Raman amplifier having an increased dynamic range, and particularly for laser pump sources and a method of pumping Raman fiber amplifiers over a greater dynamic range. In a multi-channel optical system, optical amplifiers must be able to provide gains over a large dynamic range, which is determined by the distribution of node-to-node distances in the network, as well as the number of channels. The present invention has found that the dynamic range of a Raman amplifier can be significantly increased by using pulse width modulation to pulse pump current at or near the minimum current stability threshold, in order to produce lower power output. The duty cycle of the pulsed current is selected to achieve a time-averaged operating condition, thus the time averaged pump power can be reduced in a linear fashion well below the capability of a continuous wave system.

Abstract: A Lyot depolarizer for depolarizing a laser with multiple longitudinal modes comprises two segments of PM fiber optimized for length as a function of the longitudinal mode spacing of the laser source, and not as taught in the prior art as a function of the laser coherence length. The present invention has found secondary coherence peaks in the coherence function of a multiple longitudinal mode source, which can significantly worsen the DoP if the PM fiber lengths are significantly extended beyond optimum, contrary to the teaching in the prior art. The present invention makes use of the periodic structure of the source spectrum by converting half the longitudinal modes to an orthogonal polarization state. As a result a significantly shorter fiber depolarizer is needed than for a single longitudinal mode source. Greater temperature stability is achieved by properly adjusting the lengths of both segments of PM fiber.

Abstract: An optical transmission system that employs a Raman amplifier including a Raman pump for introducing depolarized pump light into the fiber. The pump includes an optical source generating a polarized optical pump signal, an optical splitter that splits the pump signal into a first pump portion and a second pump portion, and a beam combiner that combines the first pump portion and the second pump portion into the depolarized pump light. Further, the pump includes a delay device, such as a length of fiber, that causes the first pump portion to propagate farther from the beam splitter to the beam combiner than the second pump portion. The length of fiber is longer than the coherence length of the pump signal.

Abstract: A device for transferring data arrays between at least two buses, the device comprising storage means for storing at least one data array, a first input/output interface for transferring data arrays in a first direction from a first of the buses (RBUS) to the storage means and in a second direction from the storage means to the first bus (RBUS), a second input/output interface for transferring data arrays in a third direction from a second of the buses (MBUS) to the storage means and in a fourth direction from the storage means to the second bus (MBUS), the first and second interfaces being concurrently operable in each clock cycle, the device comprising means for receiving an instruction word within a clock cycle, the first interface being provided with first selecting means for selecting one of said first and second directions and the second interface being provided with second selecting means for selecting one of said third and fourth directions, the first and second selecting means being connected to said

Abstract: An erbium doped fiber amplifier that includes two separate variable optical attenuators that provide signal attenuation to eliminate spectrum tilt of the amplified optical signal. The erbium doped fiber amplifier includes a first pre-amplifier stage, a second pre-amplifier stage and a power amplifier stage. A primary variable optical attenuator is positioned between the first pre-amplifier stage and the second pre-amplifier stage, and a secondary variable optical attenuator is positioned between the second pre-amplifier stage and the power amplifier stage. By providing two separate variable optical attenuators at two different locations, the internal loss variation in the erbium doped fiber amplifier is averaged to provide an improved amplifier design and noise figure performance.