Patents by Inventor Steven Seaman
Steven Seaman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11980565Abstract: Introduced here are pressure-mitigation apparatuses for mitigating the pressure applied to a human body by the support surface of an object. The pressure-mitigation apparatus can include a series of chambers that can be individually controlled to vary the pressure therein. By varying the chamber pressure, the main point of pressure applied by the support surface to the human body may be moved across the surface of the human body. An attachment apparatus may be used to securely adhere the pressure-mitigation apparatus to the support surface.Type: GrantFiled: March 25, 2019Date of Patent: May 14, 2024Assignee: TurnCare, Inc.Inventors: Rafael Paolo Squitieri, Robert Charles Deutsch, Steven Bruce Frazier, Robert Loiacono, Linda Seaman, Erica Kelly
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Patent number: 11981099Abstract: Introduced here are methods, apparatuses, and systems for mitigating the contact pressure applied to a human body by the surface of an object, such as a chair, bed, or table. A pressure-mitigation apparatus can include a series of chambers whose pressure can be individually varied. When placed between a patient and a contact surface, a controller can vary the contact pressure on the human body by controllably inflating one or more chambers, deflating one or more chambers, or any combination thereof. By monitoring the pressure in each chamber over time, the controller can also gain an enhanced understanding of movement(s) performed by the human body when positioned on the pressure-mitigation apparatus.Type: GrantFiled: January 25, 2022Date of Patent: May 14, 2024Assignee: TurnCare, Inc.Inventors: Rafael Paolo Squitieri, Robert Charles Deutsch, Steven Bruce Frazier, Robert Loiacono, Linda Seaman, Erica Kelly
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Patent number: 11963929Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.Type: GrantFiled: May 2, 2023Date of Patent: April 23, 2024Assignee: CORNING INCORPORATEDInventors: Connor Thomas O'Malley, Sinue Gomez-Mower, Weirong Jiang, Joseph Michael Matusick, Christie Leigh McCarthy, Christy Lynn Chapman, John Stephen Peanasky, Shivani Rao Polasani, James Ernest Webb, Michael Clement Ruotolo, Jr., Bryan James Musk, Jared Seaman Aaldenberg, Eric Lewis Allington, Douglas Miles Noni, Jr., Amber Leigh Tremper, Kristen Dae Waight, Kevin Patrick McNelis, Patrick Joseph Cimo, Steven Edward DeMartino, Robert Anthony Schaut, Adam Robert Sarafian
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Patent number: 11963928Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.Type: GrantFiled: May 2, 2023Date of Patent: April 23, 2024Assignee: CORNING INCORPORATEDInventors: James Ernest Webb, Sinue Gomez-Mower, Weirong Jiang, Joseph Michael Matusick, Christie Leigh McCarthy, Connor Thomas O'Malley, John Stephen Peanasky, Shivani Rao Polasani, Steven Edward DeMartino, Michael Clement Ruotolo, Jr., Bryan James Musk, Jared Seaman Aaldenberg, Eric Lewis Allington, Douglas Miles Noni, Jr., Amber Leigh Tremper, Kristen Dae Waight, Kevin Patrick McNelis, Patrick Joseph Cimo, Christy Lynn Chapman, Robert Anthony Schaut, Adam Robert Sarafian
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Patent number: 11851498Abstract: Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of (a) cancer or (b) tumor vasculature in a mammal and methods of (a) treating or preventing cancer or (b) reducing tumor vasculature in a mammal are also disclosed.Type: GrantFiled: March 9, 2020Date of Patent: December 26, 2023Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, BioMed Valley Discoveries, Inc.Inventors: Dimiter S. Dimitrov, Zhongyu Zhu, Bradley St. Croix, Steven Seaman, Saurabh Saha, Xiaoyan Michelle Zhang, Gary A. DeCrescenzo, Dean Welsch
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Publication number: 20230032465Abstract: An improved antibody-drug conjugate (ADC) targeting CD276-positive tumors is described. The ADC includes a CD276-specific IgG1 antibody having a heavy chain modified to prevent interaction of its Fc domain with endogenous Fc receptors and to introduce a cysteine for site-specific conjugation of the drug. The CD276-specific ADC is capable of potently eradicating CD276-positive tumors in several animal models.Type: ApplicationFiled: December 8, 2020Publication date: February 2, 2023Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human ServicesInventors: Brad St. Croix, Yang Feng, Steven Seaman
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Publication number: 20200199246Abstract: Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of (a) cancer or (b) tumor vasculature in a mammal and methods of (a) treating or preventing cancer or (b) reducing tumor vasculature in a mammal are also disclosed.Type: ApplicationFiled: March 9, 2020Publication date: June 25, 2020Inventors: Dimiter S. Dimitrov, Zhongyu Zhu, Bradley St. Croix, Steven Seaman, Saurabh Saha, Xiaoyan Michelle Zhang, Gary A. DeCrescenzo, Dean Welsch
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Patent number: 10604582Abstract: Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of (a) cancer or (b) tumor vasculature in a mammal and methods of (a) treating or preventing cancer or (b) reducing tumor vasculature in a mammal are also disclosed.Type: GrantFiled: September 16, 2015Date of Patent: March 31, 2020Assignees: The United States Of America, as represented by The Secretary, Department of Health, Biomed Valley Discoveries, Inc.Inventors: Dimiter S. Dimitrov, Zhongyu Zhu, Bradley St. Croix, Steven Seaman, Saurabh Saha, Xiaoyan Michelle Zhang, Gary A. DeCrescenzo, Dean Welsch
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Publication number: 20180186890Abstract: Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric N antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of (a) cancer or (b) tumor vasculature in a mammal and methods of (a) treating or preventing cancer or (b) reducing tumor vasculature in a mammal are also disclosed.Type: ApplicationFiled: September 16, 2015Publication date: July 5, 2018Inventors: Dimiter S. Dimitrov, Zhongyu Zhu, Bradley St. Croix, Steven Seaman, Saurabh Saha, Xiaoyan Michelle Zhang, Gary A. DeCrescenzo, Dean Welsch
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Publication number: 20160194720Abstract: Methods of inhibiting pathological angiogenesis in a subject are disclosed. In particular examples, the method includes administering a therapeutically effective amount of a composition to a subject wherein the composition includes a specific binding agent that preferentially binds to one or more pathological angiogenesis marker proteins including Vscp, CD276, ETSvg4 (Pea3), CD137(4-1BB), MiRP2, Ubiquitin D (Fat10), Doppel (prion-PLP), Apelin, Plgf, Ptprn (IA-2), CD109, Ankylosis, and collagen VIII?1. In additional examples, methods to deliver a therapeutic agent to a brain or liver endothelial cell are also disclosed.Type: ApplicationFiled: November 30, 2015Publication date: July 7, 2016Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServInventors: Brad St. Croix, Steven Seaman
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Patent number: 8440411Abstract: Methods of inhibiting pathological angiogenesis in a subject are disclosed. In particular examples, the method includes administering a therapeutically effective amount of a composition to a subject wherein the composition includes a specific binding agent that preferentially binds to one or more pathological angiogenesis marker proteins including Vscp, CD276, ETSvg4 (Pea3), CD137(4-1BB), MiRP2, Ubiquitin D (Fat10), Doppel (prion-PLP), Apelin, Plgf, Ptprn (IA-2), CD109, Ankylosis, and collagen VIII?1. In additional examples, methods to deliver a therapeutic agent to a brain or liver endothelial cell are also disclosed.Type: GrantFiled: March 21, 2011Date of Patent: May 14, 2013Assignee: The United States of America as Represented by the Secretary of the Department of Health and Human ServicesInventors: Brad St. Croix, Steven Seaman
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Publication number: 20110207141Abstract: Methods of inhibiting pathological angiogenesis in a subject are disclosed. In particular examples, the method includes administering a therapeutically effective amount of a composition to a subject wherein the composition includes a specific binding agent that preferentially binds to one or more pathological angiogenesis marker proteins including Vscp, CD276, ETSvg4 (Pea3), CD137(4-1BB), MiRP2, Ubiquitin D (Fat10), Doppel (prion-PLP), Apelin, Plgf, Ptprn (IA-2), CD109, Ankylosis, and collagen VIII?1. In additional examples, methods to deliver a therapeutic agent to a brain or liver endothelial cell are also disclosed.Type: ApplicationFiled: March 21, 2011Publication date: August 25, 2011Inventors: Brad St. Croix, Steven Seaman
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Publication number: 20100028256Abstract: Methods of inhibiting pathological angiogenesis in a subject are disclosed. In particular examples, the method includes administering a therapeutically effective amount of a composition to a subject wherein the composition includes a specific binding agent that preferentially binds to one or more pathological angiogenesis marker proteins including Vscp, CD276, ETSvg4 (Pea3), CD137(4-1BB), MiRP2, Ubiquitin D (Fat10), Doppel (prion-PLP), Apelin, Plgf, Ptprn (IA-2), CD109, Ankylosis, and collagen VIII?1. In additional examples, methods to deliver a therapeutic agent to a brain or liver endothelial cell are also disclosed.Type: ApplicationFiled: June 28, 2007Publication date: February 4, 2010Inventors: Brad St. Croix, Steven Seaman