Abstract: Provided are methods of determining if a subject has a cardiac disorder or is at risk for developing a cardiac disorder.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: Instrument transformer for power grid conductor includes: a current sensing device having a secondary coil winding through which a power grid primary conductor is capable of extending and connecting to a primary conductor connector, a first low voltage (LV) lead connected to the secondary coil winding and a LV connector, and a first high voltage (HV) lead connected between the primary conductor connector and a HV connector, the voltage sensing device having a core with a primary coil winding, a second HV lead connected between a HV connector and primary coil winding, a grounding conductor connected between the primary coil winding and an output terminal, a second LV lead connected between a LV connector and output terminal, wherein the current and voltage sensing devices are electrically connected via HV and LV connectors, and wherein the current and voltage sensing devices are separable when corresponding HV and LV connectors are disconnected.

Abstract: Pairing and configuring a computing device for use in a meeting space is provided. An appliance may communicate a broadcast to a computing device which announces the availability of a meeting space for a meeting. The computing device may establish a connection with the appliance. The computing device may then join the meeting in the meeting space.

Abstract: A split core current sensor a core subdivided into a first core section and a second core section, each of which have a first end and a second end. The first core section and the second core section are spaced apart by a gap. The sensor also includes a plurality of coil windings disposed about the core. A first coil winding is disposed proximate to the first end of the first core section; a second coil winding is disposed proximate to the second end of the first core section; a third coil winding is disposed proximate to the first end of the second core section; and a fourth coil winding is disposed proximate to a second end of the second core section. Each of the first core section and the second core section include a central portion disposed between the first and second ends that is free of coil windings.

Abstract: A submersible current sensor for sensing a current in a submerged conductor includes: a split core current transformer constructed to generate an output representative of the current carried by the conductor, the split core having a first core member, a first winding disposed about at least a portion of the first core member; a second core member; and a second winding disposed about at least a portion of the second core member; and a housing, the housing including: a first housing member constructed to house the first core member and the first winding; and a second housing member constructed to house the second core member and the second winding.

Abstract: Pairing and configuring a computing device for use in a meeting space is provided. An appliance may communicate a broadcast to a computing device which announces the availability of a meeting space for a meeting. The computing device may establish a connection with the appliance. The computing device may then join the meeting in the meeting space.

Abstract: Provided are methods for screening a subject for cancer. The methods involve obtaining a blood sample from the subject and determining a level of Bridging Integrator 1 (BIN1) isoforms comprising exon 12a in the sample. Optionally, the method involves determining a level of 12a+/13? BIN isoform (comprising exon 12a but lacking exon 13) in the sample. An elevated level of 12a+(e.g., 12a+/13?) BIN1 isoforms in the blood sample indicates the subject has cancer. Also provided are methods for determining efficacy of a cancer therapy in a subject and methods of treating cancer. Isolated antibodies that selectively bind human 12a+ BIN1 are also provided as well as kits for determining 12a+/13? BIN1 isoforms.

Abstract: The present invention relates to compositions and methods for treating cancer. More specifically, the present invention relates to compositions of engineered oncolytic viruses for administration to a subject with cancer that specifically lyse tumor cells and actively target tumor cells and cell debris to antigen presenting cells, in order to generate anti-tumor immunity.

Abstract: Pairing and configuring a computing device for use in a meeting space is provided. An appliance may communicate a broadcast to a computing device which announces the availability of a meeting space for a meeting. The computing device may establish a connection with the appliance. The computing device may then join the meeting in the meeting space.

Abstract: Provided are methods for determining skeletal muscle mass in subject. Also provided are methods for diagnosing a neurological condition or disease or a condition or disease associated with reduced skeletal muscle mass in a subject. Further provided are purified antibodies that bind specifically to a BIN1 polypeptide that is expressed specifically in skeletal muscle.

Abstract: Provided are methods of determining if a subject has a cardiac disorder or is at risk for developing a cardiac disorder.

Abstract: Provided are methods for screening a subject for cancer. The methods involve obtaining a blood sample from the subject and determining a level of Bridging Integrator 1 (BIN1) isoforms comprising exon 12a in the sample. Optionally, the method involves determining a level of 12a+/13? BIN isoform (comprising exon 12a but lacking exon 13) in the sample. An elevated level of 12a+ (e.g., 12a+/13?) BIN1 isoforms in the blood sample indicates the subject has cancer. Also provided are methods for determining efficacy of a cancer therapy in a subject and methods of treating cancer. Isolated antibodies that selectively bind human 12a+ BIN1 are also provided as well as kits for determining 12a+/13? BIN1 isoforms.

Abstract: A frequency divider apparatus includes a micro-electro-mechanical system (“MEMS”) divider that is configured to be driven by an input signal. The MEMS divider includes a passive mechanical device that generates multiple output signals. Each of the output signals has a frequency less than a frequency of the input signal.

Abstract: In one embodiment, a content aggregation viewer may present a container layout to summarize a data item set to a user. The content aggregation viewer may determine a viewport dimension for a viewport of a user interface of a content aggregation application to present a data item set to a user. The content aggregation viewer may automatically arrange a container set summarizing the data item set in a container layout based on the viewport dimension. The content aggregation viewer may set a parallel container dimension of a data item container of the container set having a variable dimension size in a direction of the viewport dimension based on the viewport dimension. The content aggregation viewer may present the container set in the container layout to the user.

Abstract: An electrostatic shield for controlling the electrostatic field between a high voltage conductor and a low voltage conductor in an instrument transformer is provided. The instrument transformer has a current transformer and a voltage transformer. The current transformer has a split core which includes a first core segment and a second core segment. When the first core segment adjoins the second core segment, a current transformer is formed, having a core formed from the first and second core segments. The high voltage conductor runs between the first and second core segments of the current transformer. The first core segment is encapsulated in a polymer resin and when encapsulated, forms a first encasement. The second core segment has a low voltage winding mounted thereon. The electrostatic shield is disposed between the low voltage winding and the high voltage conductor. A second encasement is formed by encapsulating the electrostatic shield, low voltage winding and second core segment in a polymer resin.

Abstract: A computer-implemented system including a lead-engine server operatively coupled to an administrator computing system and a group of mobile devices. The lead-engine server may be configured to assign field user data among multiple campaign groups and define multiple, different campaigns for different groups of field users. The lead-engine server may also generate incentive programs and track the lead-generation input associated with the first field user. The lead-engine server may also be configured to generate a field-user specific website and communicate promotional information to potential leads that includes a link to the website.

Abstract: A frequency divider apparatus includes a micro-electro-mechanical system (“MEMS”) divider that is configured to be driven by an input signal. The MEMS divider includes a passive mechanical device that generates multiple output signals. Each of the output signals has a frequency less than a frequency of the input signal.

Abstract: The present disclosure is directed to a bracket and electrical assembly including such bracket for mounting or securing to a concrete masonry unit (CMU).

Abstract: Imaging devices may include an array of image pixels arranged in rows and columns coupled to processing circuitry. The processing circuitry may include histogram generation circuitry and extremum pixel value identification circuitry. The histogram generation circuitry may include sub-histogram generation circuitry that generates pixel value sub-histograms each of which includes pixel values generated by pixels from respective subsets of the rows in the array. Histogram accumulation circuitry may combine the sub-histograms to generate an accumulated histogram. The extremum identification circuitry may process a set of pixel value patches. The identification circuitry may include a first stage of comparator circuitry for identifying an extremum value of each column in the set of patches, a second stage of comparator circuitry for identifying an extremum value of each patch in the set, and a third stage of comparator circuitry for identifying an extremum of the set of pixel value patches.