Abstract: A replaceable sleeve configured to cover a writing instrument. The writing instrument has a primary end located opposite a secondary end. The secondary end of the writing instrument has an outer ridge having a step. The sleeve has an end having a secondary opening located opposite another end having a primary opening. The primary opening of the sleeve receives the primary end of the writing instrument. The primary end of the writing instrument is configured to protrude from the secondary opening of the sleeve. An inner ridge is connected to an inner wall surface of the sleeve. When the sleeve covers a substantial amount of the writing instrument, the secondary end of the replaceable sleeve conforms around the outer ridge of the writing instrument. The outer ridge has a step that interlocks with the inner ridge of the sleeve, thereby, retaining the sleeve on the writing instrument.

Abstract: A smart phone used by an end user includes a positioning circuit; a computer readable memory; and an app resident on the computer readable memory. The app is configured to cause the positioning circuit periodically to determine a preferred location of the smart phone and transmit the preferred location to a remote server via a network. The app executes a plurality of local rules based on the preferred location and receives location-specific content that is selected based on the preferred location from the server via the network. The location-specific content is presented to the end user. A software development kit for generating a smart phone app facilitates quick app generation.

Abstract: The present invention relates to compounds that are useful as inhibitors of the activity of one or more isoforms of the serine/threonine kinase, AKT. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.

Abstract: The present invention relates to compounds that are useful as inhibitors of the activity of one or more isoforms of the serine/threonine kinase, AKT. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.