Patents by Inventor Steven Shire

Steven Shire has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reduced-Viscosity Concentrated Protein Formulations
    Publication number: 20070116700
    Abstract: The present application concerns concentrated protein formulations with reduced viscosity, which are particularly suitable for subcutaneous administration. The application further concerns a method for reducing the viscosity of concentrated protein formulations.
    Type: Application
    Filed: December 15, 2006
    Publication date: May 24, 2007
    Applicant: Genentech, Inc.
    Inventors: Jun Liu, Steven Shire
  • Methods of treating IgE-mediated disorders comprising the administration of high concentration anti-IgE antibody formulations
    Publication number: 20070086995
    Abstract: The present application relates to methods of treating IgE-mediated disorders comprising the administration of highly concentrated anti-IgE antibody formulations with reduced viscosity that are stable, relatively isotonic and are of low turbidity. The formulations are particularly suitable for subcutaneous administration.
    Type: Application
    Filed: October 13, 2006
    Publication date: April 19, 2007
    Applicant: Genentech, Inc.
    Inventors: Jun Liu, Steven Shire
  • HIGH CONCENTRATION ANTIBODY AND PROTEIN FORMULATIONS
    Publication number: 20070053900
    Abstract: The present application relates to highly concentrated antibody and protein formulations with reduced viscosity that are stable, relatively isotonic and are of low turbidity. The formulations are particularly suitable for subcutaneous administration. The application further describes articles of manufacture containing such formulations and method for using them to treat disorders treatable by the formulated antibody or protein.
    Type: Application
    Filed: October 13, 2006
    Publication date: March 8, 2007
    Applicant: Genentech, Inc.
    Inventors: Jun Liu, Steven Shire
  • METHODS FOR TREATMENT OF ALLERGIC ASTHMA
    Publication number: 20070020256
    Abstract: Methods of treatment of allergic asthma with IgE antagonists, including anti-IgE antibodies, IgE variants, peptide antagonists, peptidomimetics and other small molecules, are described.
    Type: Application
    Filed: September 22, 2006
    Publication date: January 25, 2007
    Inventors: Robert Fick, Paula Jardieu, Monika Schoenhoff, Steven Shire
  • Protein formulation
    Publication number: 20060275306
    Abstract: A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein.
    Type: Application
    Filed: May 26, 2006
    Publication date: December 7, 2006
    Inventors: James Andya, Jeffrey Cleland, Chung Hsu, Xanthe Lam, David Overcashier, Steven Shire, Janet Yang, Sylvia Wu
  • Treating a mammal with a formulation comprising an antibody which binds IgE
    Publication number: 20060099201
    Abstract: A method of treating a mammal with a formulation comprising an antibody which binds IgE as described.
    Type: Application
    Filed: December 16, 2005
    Publication date: May 11, 2006
    Applicant: Genentech, Inc.
    Inventors: James Andya, Chung Hsu, Steven Shire, Sylvia Wu
  • Reduced-viscosity concentrated protein formulations
    Publication number: 20050175603
    Abstract: The present application concerns concentrated protein formulations with reduced viscosity, which are particularly suitable for subcutaneous administration. The application further concerns a method for reducing the viscosity of concentrated protein formulations.
    Type: Application
    Filed: February 28, 2005
    Publication date: August 11, 2005
    Inventors: Jun Liu, Steven Shire
  • Methods of treating IgE-mediated disorders comprising the administration of high concentration anti-IgE antibody formulations
    Publication number: 20050158303
    Abstract: The present application relates to methods of treating IgE-mediated disorders comprising the administration of highly concentrated anti-IgE antibody formulations with reduced viscosity that are stable, relatively isotonic and are of low turbidity. The formulations are particularly suitable for subcutaneous administration.
    Type: Application
    Filed: December 16, 2004
    Publication date: July 21, 2005
    Inventors: Jun Liu, Steven Shire