Patents by Inventor Steven Signs

Steven Signs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection and amplification of ligands
    Patent number: 7927827
    Abstract: A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: April 19, 2011
    Assignee: Kent State University
    Inventors: Gary D. Niehaus, Christopher J. Woolverton, Kathleen J. Doane, Steven P. Schmidt, Steven A. Signs
  • Detection and amplification of ligands
    Patent number: 7732219
    Abstract: A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: June 8, 2010
    Assignee: Kent State University
    Inventors: Christopher J. Woolverton, Gary D. Niehaus, Kathleen J. Doane, Oleg D. Lavrentovich, Steven P. Schmidt, Steven A. Signs
  • DETECTION AND AMPLIFICATION OF LIGANDS
    Publication number: 20080138244
    Abstract: A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.
    Type: Application
    Filed: September 10, 2007
    Publication date: June 12, 2008
    Applicant: KENT STATE UNIVERSITY
    Inventors: Christopher J. Woolverton, Gary D. Niehaus, Kathleen J. Doane, Oleg D. Lavrentovich, Steven P. Schmidt, Steven A. Signs
  • DETECTION AND AMPLIFICATION OF LIGANDS
    Publication number: 20070243593
    Abstract: A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.
    Type: Application
    Filed: May 21, 2007
    Publication date: October 18, 2007
    Applicant: KENT STATE UNIVERSITY
    Inventors: Christopher Woolverton, Gary Niehaus, Kathleen Doane, Steven Schmidt, Steven Signs
  • DETECTION AND AMPLIFICATION OF LIGANDS
    Publication number: 20070218508
    Abstract: A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.
    Type: Application
    Filed: May 21, 2007
    Publication date: September 20, 2007
    Applicant: KENT STATE UNIVERSITY
    Inventors: Gary Niehaus, Christopher Woolverton, Kathleen Doane, Steven Schmidt, Steven Signs
  • Detection and amplification of ligands
    Patent number: 7267957
    Abstract: A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: September 11, 2007
    Assignee: Kent State University
    Inventors: Christopher J Woolverton, Gary D Niehaus, Kathleen J Doane, Oleg D Lavrentovich, Steven P Schmidt, Steven A Signs
  • DETECTION AND AMPLIFICATION OF LIGANDS
    Publication number: 20070059780
    Abstract: A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.
    Type: Application
    Filed: April 26, 2002
    Publication date: March 15, 2007
    Applicant: Kent State University
    Inventors: Christopher Woolverton, Gary Niehaus, Kathleen Doane, Oleg Lavrentovich, Steven Schmidt, Steven Signs
  • Detection and amplification of ligands
    Patent number: 6171802
    Abstract: A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.
    Type: Grant
    Filed: June 10, 1998
    Date of Patent: January 9, 2001
    Assignee: Kent State University
    Inventors: Christopher J. Woolverton, Gary D. Niehaus, Kathleen J. Doane, Oleg Lavrentovich, Steven P. Schmidt, Steven A. Signs