Abstract: Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample. They may be used to isolate and enumerate rare cells, including for example the detection and diagnosis of cancers, cancer staging, or evaluating the effectiveness of a therapeutic intervention, or detecting pathogenic bacteria. The device may optionally be used to nondestructively capture and later to release target cells.

Abstract: Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood, The system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample. They may he used to isolate and enumerate rare cells, including for example the detection and diagnosis of cancers, cancer staging, or evaluating the effectiveness of a therapeutic intervention, or detecting pathogenic bacteria, The device may optionally he used to nondestructively capture and later to release target cells.

Abstract: This invention provides methods and compositions for capturing circulating tumor cells (CTCs) as well as various divergent CTC phenotypes using seprase-specific affinity reagents. Methods of analyzing CTCs and assessing their metastatic potential in vivo and in vitro are also disclosed.

Abstract: A fluid array, comprises: (a) a fluid input header, (b) a fluid output header, and (c) a plurality of (preferably at least 26) parallel fluid channels, each of said fluid channels connected to both said fluid input header and said fluid output header in a Z-array configuration. Methods of using the same and fuel cells comprising such arrays are also described, along with methods of optimizing flow therein.

Abstract: This invention provides methods and compositions for capturing circulating tumor cells (CTCs) as well as various divergent CTC phenotypes using seprase-specific affinity reagents. Methods of analyzing CTCs and assessing their metastatic potential in vivo and in vitro are also disclosed.

Abstract: This invention provides methods and compositions for capturing circulating tumor cells (CTCs) as well as various divergent CTC phenotypes using seprase-specific affinity reagents. Methods of analyzing CTCs and assessing their metastatic potential in vivo and in vitro are also disclosed.

Abstract: This invention provides methods and compositions for capturing circulating tumor cells (CTCs) as well as various divergent CTC phenotypes using seprase-specific affinity reagents. Methods of analyzing CTCs and assessing their metastatic potential in vivo and in vitro are also disclosed.

Abstract: A modular, reconfigurable entertainment and data system provides data to at least one user. A cabinet is provided which contains a plurality of module receiving rails therein. A power supply module is positioned on a first one of the rails and provides an operating potential. An entertainment/data module is positioned on a second rail and a control module is positioned on a third one of the module receiving rails and provides an interface between the user and the entertainment/data module.

Abstract: An accurate and inexpensive integral micro-optical system for coupling and aligning optical fibers with other optical components, such as other optical fibers, diffusers, beam shapers, beam splitters, mirrors, or lenses is disclosed. The micro-optical coupler disclosed comprises one or more fiberport collimators and one or more microlens arrays, optically aligned during fabrication so that an optical fiber, or other source of light, was coupled to another optical fiber, or other light receiver, by simple inserting the optical source in one side of the micro-coupler and inserting the optical receiver in the other side of the micro-coupler. Often the fabrication process for this system can be done in a single lithography procedure. Since the optical axis of each component was aligned during the fabrication step, no subsequent alignment was required.

Abstract: An accurate and inexpensive integral micro-optical system for coupling and aligning optical fibers with other optical components, such as other optical fibers, diffusers, beam shapers, beam splitters, mirrors, or lenses is disclosed. The micro-optical coupler disclosed comprises one or more fiberport collimators and one or more microlens arrays, optically aligned during fabrication so that an optical fiber, or other source of light, was coupled to another optical fiber, or other light receiver, by simple inserting the optical source in one side of the micro-coupler and inserting the optical receiver in the other side of the micro-coupler. Often the fabrication process for this system can be done in a single lithography procedure. Since the optical axis of each component was aligned during the fabrication step, no subsequent alignment was required.