Patents by Inventor Steven Stanway

Steven Stanway has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic peptide ligands specific for TREM2
    Patent number: 11904020
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TREM2. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by TREM2.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: February 20, 2024
    Assignee: BicycleTx Limited
    Inventors: Paul Brennan, Amy Brown, Liuhong Chen, John Davis, Yuliya Demydchuk, Donatella Di Rienzo, Ellen Gowans, Rama McCrory, Emma Mead, Emma Murphy, Mike Rigby, Michael Skynner, Tom Smith, Steven Stanway
  • BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TREM2
    Publication number: 20220296726
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TREM2. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by TREM2.
    Type: Application
    Filed: March 18, 2022
    Publication date: September 22, 2022
    Applicant: BicycleTx Limited
    Inventors: Paul Brennan, Amy Brown, Liuhong Chen, John Davis, Yuliya Demydchuk, Donatella Di Rienzo, Ellen Gowans, Rama McCrory, Emma Mead, Emma Murphy, Mike Rigby, Michael Skynner, Tom Smith, Steven Stanway
  • BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TRANSFERRIN RECEPTOR 1 (TfR1)
    Publication number: 20220194988
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TfR1. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, and multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder through TfR1 mediated delivery of a therapeutic agent.
    Type: Application
    Filed: November 12, 2021
    Publication date: June 23, 2022
    Inventors: Ellen GOWANS, Gemma Elizabeth MUDD, Michael RIGBY, Punit SETH, Michael SKYNNER, Steven STANWAY, Liudvikas URBONAS, Katerine VAN RIETSCHOTEN
  • 5,6-TRIMETHYLENEPYRIMIDIN-4-ONE COMPOUNDS
    Publication number: 20070155762
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis.
    Type: Application
    Filed: November 17, 2006
    Publication date: July 5, 2007
    Inventors: Colin Leach, Stephen Smith, Steven Stanway
  • Pyrimidine compounds
    Publication number: 20070123549
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis.
    Type: Application
    Filed: November 21, 2006
    Publication date: May 31, 2007
    Inventors: Deirdre Hickey, Robert Ife, Colin Leach, Ivan Pinto, Stephen Smith, Steven Stanway
  • Hydroxyethylamine derivatives for the treatment of alzheimer's disease
    Publication number: 20060025459
    Abstract: The present invention relates to novel hydroxyethylamine compounds having Asp2 (?-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated ?-amyloid levels or ?-amyloid deposits, particularly Alzheimer's disease.
    Type: Application
    Filed: December 3, 2003
    Publication date: February 2, 2006
    Inventors: Emmanuel Demont, Andrew Faller, David Macpherson, Peter Milner, Alan Naylor, Sally Redshaw, Steven Stanway, David Vesey, Daryl Walter
  • Benzamide derivatives, processes for their preparation, and their pharmaceutical use
    Publication number: 20050085520
    Abstract: The present invention relates to novel hydroxyethylene compounds having Asp2 (?-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated ?-amyloid levels or ?-amyloid deposits, particularly Alzheimer's disease.
    Type: Application
    Filed: November 29, 2002
    Publication date: April 21, 2005
    Inventors: Andrew Faller, David Macpherson, Peter Milner, Steven Stanway, Leontine Trouw
  • Heterocyclic derivatives of glycinamide and their medical use
    Publication number: 20050043335
    Abstract: Compounds of the formula (I) are inhibitors of the enzyme Lp-PLA2? and are of use in therapy, in particular for treating atherosclerosis.
    Type: Application
    Filed: November 8, 2002
    Publication date: February 24, 2005
    Inventors: Richard Elliott, Deidre Hickey, Robert Ife, Colin Leach, John Liddle, Ivan Pinto, Stephen Smith, Steven Stanway
  • Novel compounds
    Publication number: 20050033052
    Abstract: Pyrimidone and pyridone compounds of the formula: are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
    Type: Application
    Filed: November 8, 2002
    Publication date: February 10, 2005
    Inventors: Colin Leach, Ivan Pinto, Stephen Smith, Steven Stanway
  • Pyridinone derivatives for treatment of atherosclerosis
    Publication number: 20050014793
    Abstract: Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis. Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
    Type: Application
    Filed: July 28, 2004
    Publication date: January 20, 2005
    Inventors: Deirdre Hickey, Robert Ife, Colin Leach, John Liddle, Ivan Pinto, Stephen Smith, Steven Stanway