Abstract: A method for delivering fluid to the brain of a subject using an intraparenchymal catheter, the method comprising the step of inserting the catheter 5 into the brain using a posterior to anterior approach and methods of treating neurodegenerative disorders using this delivery method, as well as methods for delivering fluid to an elongate structure of the brain using an intraparenchymal catheter, the method comprising the step of inserting a catheter into the brain along an insertion axis that is substantially aligned with a long axis of the elongate structure.

Abstract: A variable volume fluid dispenser (10) for medical therapy and diagnostic use includes a tubular body (12) having a proximal end (16) and a distal end (14). Each end includes a fluidic connector (18, 26) and the tubular body (12) defines an interior volume. A piston (30) is located within the interior volume and is configured to create a fluid and gas seal within the interior volume of the tubular body (12) and to move axially under the action of a displacement fluid via the fluidic connectors (18, 26) between the proximal end (16) and the distal end (14). The position of the piston (30) relative to the distal end defines the volume of fluid to be dispensed.

Abstract: A neurosurgical apparatus for convection enhanced delivery of an infusate to the brain parenchyma, the apparatus comprising: a guide tube for insertion into the brain and having a proximal end, a distal end and a through-bore for passage of a cannula; wherein at least an outer layer (24) of the guide tube is of a hydrophobic material that is resiliently deformable and porous to allow passage of air. Also provided is a kit for convection enhanced delivery of an infusate to the brain parenchyma and a surgical method for convection enhanced delivery of an infusate to the brain parenchyma.

Abstract: A surgical guide hub for implanting in an aperture formed in a skull and made along a trajectory to a brain target, wherein the guide hub comprises: a through-bore for delivering a device therethrough and along the trajectory; at least one first formation on an external surface for securing the hub within the aperture in a skull; and at least one second formation on the surface of the through-bore for securing a guide device, an implantable device, or a cap to the hub. Also provided are a jig for setting the depth of insertion of a surgical tool into a patient during surgery, and a method of preparing an operative length of a surgical tool.

Abstract: A neurosurgical kit includes a catheter and a guide tube. The catheter includes a distal section of tubing having a distal end with a port or ports for delivering fluid to a target site within the brain. The distal section of tubing has an outer diameter that is smaller than an internal diameter of the guide tube. The catheter and guide tube are arranged such that, when the catheter is inserted into the guide tube to locate the port or ports at the target site, a recess is provided in a distal end section of the guide tube between the guide tube and the distal section of tubing of the catheter.

Abstract: Apparatus for delivering therapeutic agents to the central nervous system of a subject is described. The apparatus includes at least one intracranial catheter and a percutaneous access device. The percutaneous access device includes a body having at least one extracorporeal surface and at least one subcutaneous surface, the body defining at least one port for connection to an implanted intracranial catheter. The port is accessible from the extracorporeal surface of the device, but is provided with a seal such as a rubber bung between the lumen of the port and the extracorporeal surface. The percutaneous access device may have more than two ports and/or a flange. A method of implanting the percutaneous access device is also described.

Abstract: Neurosurgical apparatus has a guidance device having a guide tube and a neurosurgical instrument for insertion into the guide tube. The inner surface of the guide tube is arranged, for example profiled, to at least partially engage the outer surface of the neurosurgical instrument when inserted therein. The guide tube thus guides the neurosurgical instrument along a predefined path through the guide tube. At least one of the guidance device and the outer surface of the neurosurgical instrument are configured to provide a fluid return path for carrying any fluid displaced from within the guide tube during insertion of the neurosurgical instrument into the guide tube. A seal may also be provided for sealing the fluid return path.

Abstract: Neurosurgical apparatus has a guidance device having a guide tube and a neurosurgical instrument for insertion into the guide tube. The inner surface of the guide tube is arranged, for example profiled, to at least partially engage the outer surface of the neurosurgical instrument when inserted therein. The guide tube thus guides the neurosurgical instrument along a predefined path through the guide tube. At least one of the guidance device and the outer surface of the neurosurgical instrument are configured to provide a fluid return path for carrying any fluid displaced from within the guide tube during insertion of the neurosurgical instrument into the guide tube. A seal may also be provided for sealing the fluid return path.

Abstract: A method for delivering fluid to the brain of a subject using an intraparenchymal catheter, the method comprising the step of inserting the catheter 5 into the brain using a posterior to anterior approach and methods of treating neurodegenerative disorders using this delivery method, as well as methods for delivering fluid to an elongate structure of the brain using an intraparenchymal catheter, the method comprising the step of inserting a catheter into the brain along an insertion axis that is substantially aligned with a long axis of the elongate structure.

Abstract: A method for delivering fluid to the brain of a subject using an intraparenchymal catheter, the method comprising the step of inserting the catheter 5 into the brain using a posterior to anterior approach and methods of treating neurodegenerative disorders using this delivery method, as well as methods for delivering fluid to an elongate structure of the brain using an intraparenchymal catheter, the method comprising the step of inserting a catheter into the brain along an insertion axis that is substantially aligned with a long axis of the elongate structure.

Abstract: Neurosurgical apparatus has a guidance device having a guide tube and a neurosurgical instrument for insertion into the guide tube. The inner surface of the guide tube is arranged, for example profiled, to at least partially engage the outer surface of the neurosurgical instrument when inserted therein. The guide tube thus guides the neurosurgical instrument along a predefined path through the guide tube. At least one of the guidance device and the outer surface of the neurosurgical instrument are configured to provide a fluid return path for carrying any fluid displaced from within the guide tube during insertion of the neurosurgical instrument into the guide tube. A seal may also be provided for sealing the fluid return path.

Abstract: A catheter assembly for insertion into the brain. The assembly comprises a first length of tubing made of a first material. A second material surrounds the first length of tubing, the second material being more flexible than the first material and having a hardness of less than 50 Rockwell E. The second material provides damping to the first length of tubing.

Abstract: Apparatus for delivering therapeutic agents to the central nervous system of a subject is described. The apparatus includes at least one intracranial catheter and a percutaneous access device. The percutaneous access device includes a body having at least one extracorporeal surface and at least one subcutaneous surface, the body defining at least one port for connection to an implanted intracranial catheter. The port is accessible from the extracorporeal surface of the device, but is provided with a seal such as a rubber bung between the lumen of the port and the extracorporeal surface. The percutaneous access device may have more than two ports and/or a flange. A method of implanting the percutaneous access device is also described.

Abstract: A neurosurgical kit includes a catheter and a guide tub. The catheter includes a distal section of tubing having a distal end with a port or ports for delivering fluid to a target site within the brain. The distal section of tubing has an outer diameter that is smaller than an internal diameter of the guide tube. The catheter and guide tube are arranged such that, when the catheter is inserted into the guide tube to locate the port or ports at the target site, a recess is provided in a distal end section of the guide tube between the guide tube and the distal section of tubing of the catheter.

Abstract: Apparatus for delivering therapeutic agents to the central nervous system of a subject is described. The apparatus includes at least one intracranial catheter and a percutaneous access device. The percutaneous access device includes a body having at least one extracorporeal surface and at least one subcutaneous surface, the body defining at least one port for connection to an implanted intracranial catheter. The port is accessible from the extracorporeal surface of the device, but is provided with a seal such as a rubber bung between the lumen of the port and the extracorporeal surface. The percutaneous access device may have more than two ports and/or a flange. A method of implanting the percutaneous access device is also described.

Abstract: A method for delivering fluid to a brain of a subject is disclosed. This method includes the steps of: making one or more incisions in a subject; implanting one or more catheters in the brain of the subject; subcutaneously implanting a first part of a modular fluid delivery apparatus in the subject, the first part of the modular fluid delivery apparatus comprising a first length of tubing having a first end and a second end, the first end having a first fluid connector portion attached thereto and the second end being connected to the one or more catheters; and closing the one or more incisions such that the first part of the modular fluid delivery apparatus and the one or more catheters are entirely subcutaneously implanted within the subject.

Abstract: The invention concerns a cranial drill system comprising one or more surgical drill elements for drilling into the brain. The invention also concerns a cranial drilling system comprising a surgical drill element for drilling into the skull and an element for penetrating the dura. The surgical drill element may comprise a profile that forms an opening in the skull having a narrower diameter portion and a wider diameter portion and the piercing element may be arranged to be a close fit in the narrower diameter portion of the opening. The invention also concerns a cranial drill system comprising a guiding element to be located in a hole formed through the skull and a piercing element for piercing the dura. The guiding element may have a passageway or channel therein for receiving the piercing element such that the piercing element is movable relative to the guide element to pierce the dura.

Abstract: A method for delivering fluid to the brain of a subject using an intraparenchymal catheter, the method comprising the step of inserting the catheter 5 into the brain using a posterior to anterior approach and methods of treating neurodegenerative disorders using this delivery method, as well as methods for delivering fluid to an elongate structure of the brain using an intraparenchymal catheter, the method comprising the step of inserting a catheter into the brain along an insertion axis that is substantially aligned with a long axis of the elongate structure.

Abstract: A method for delivering fluid to the brain of a subject using an intraparenchymal catheter, the method comprising the step of inserting the catheter into the brain using a posterior to anterior approach and methods of treating neurodegenerative disorders using this delivery method, as well as methods for delivering fluid to an elongate structure of the brain using an intraparenchymal catheter, the method comprising the step of inserting a catheter into the brain along an insertion axis that is substantially aligned with a long axis of the elongate structure.

Abstract: The invention concerns a cranial drill system comprising one or more surgical drill elements for drilling into the brain. The invention also concerns a cranial drilling system comprising a surgical drill element for drilling into the skull and an element for penetrating the dura. The surgical drill element may comprise a profile that forms an opening in the skull having a narrower diameter portion and a wider diameter portion and the piercing element may be arranged to be a close fit in the narrower diameter portion of the opening. The invention also concerns a cranial drill system comprising a guiding element to be located in a hole formed through the skull and a piercing element for piercing the dura. The guiding element may have a passageway or channel therein for receiving the piercing element such that the piercing element is movable relative to the guide element to pierce the dura.