Patents by Inventor Steven Suchting

Steven Suchting has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies, polypeptides and uses thereof
    Patent number: 8394381
    Abstract: A method of inhibiting angiogenesis in an individual in need thereof comprising administering an antibody that selectively binds to the extracellular region of human magic roundabout (MR) to the individual. An antibody that has the amino acid sequences i) to iii), the amino acid sequences iv) to vi), or the amino acid sequences i) to vi). i) S A S S S V S Y M Y ii) L T S N L A S iii) Q Q W S S N P L T iv) D Y N L N v) V I N P N Y G T T S Y N Q K F K G vi) G R D Y F G Y. A method of inhibiting angiogenesis in an individual in need thereof comprising administering the extracellular domain (residues 1-467) of MR, or a fragment thereof that inhibits angiogenesis, to the individual. A method of inhibiting endothelial cell migration and/or proliferation comprising administering the extracellular domain of MR, or a fragment thereof that inhibits endothelial cell migration and/or proliferation.
    Type: Grant
    Filed: May 5, 2006
    Date of Patent: March 12, 2013
    Assignee: Cancer Research Technology Limited
    Inventors: Roy Bicknell, Steven Suchting, Lorna Mary Dyet Stewart
  • Antibodies, polypeptides and uses thereof
    Publication number: 20080166295
    Abstract: Provided are methods of inhibiting angiogenesis in an individual in need thereof comprising administering an antibody that selectively binds to the extracellular region of human magic roundabout (MR) to the individual. Also provided are antibodies that have the amino acid sequences i) to iii), iv) to vi), or i) to vi): i) SEQ ID NO:9, ii) SEQ ID NO:10, iii) SEQ ID NO:11, iv) SEQ ID NO:13, v) SEQ ID NO:14, vi) SEQ ID NO:15. Further provided are methods of inhibiting angiogenesis in an individual in need thereof comprising administering the extracellular domain (residues 1-467) of MR, or a fragment thereof, that inhibits angiogenesis, to the individual. Methods of inhibiting endothelial cell migration and/or proliferation comprising administering the extracellular domain of MR, or a fragment thereof, that inhibits endothelial cell migration and/or proliferation are also provided.
    Type: Application
    Filed: August 2, 2007
    Publication date: July 10, 2008
    Applicant: Cancer Research Technology Limited
    Inventors: Roy Bicknell, Steven Suchting, Lorna Mary Dyet Stewart
  • Antibodies, polypeptides and uses thereof
    Publication number: 20080019963
    Abstract: A method of inhibiting angiogenesis in an individual in need thereof comprising administering an antibody that selectively binds to the extracellular region of human magic roundabout (MR) to the individual. An antibody that has the amino acid sequences i) to iii), the amino acid sequences iv) to vi), or the amino acid sequences i) to vi): i) S A S S S V S Y M Y ii) L T S N L A S iii) Q Q W S S N P L T iv) D Y N L N v) V I N P N Y G T T S Y N Q K F K G vi) G R D Y F G Y. A method of inhibiting angiogenesis in an individual in need thereof comprising administering the extracellular domain (residues 1-467) of MR, or a fragment thereof that inhibits angiogenesis, to the individual. A method of inhibiting endothelial cell migration and/or proliferation comprising administering the extracellular domain of MR, or a fragment thereof that inhibits endothelial cell migration and/or proliferation.
    Type: Application
    Filed: August 2, 2007
    Publication date: January 24, 2008
    Applicant: Cancer Research Technology Limited
    Inventors: Roy Bicknell, Steven Suchting, Lorna Stewart
  • Antibodies, polypeptides and uses thereof
    Publication number: 20060263369
    Abstract: A method of inhibiting angiogenesis in an individual in need thereof comprising administering an antibody that selectively binds to the extracellular region of human magic roundabout (MR) to the individual. An antibody that has the amino acid sequences i) to iii), the amino acid sequences iv) to vi), or the amino acid sequences i) to vi): i) SASSSVSYMY ii) LTSNLAS iii) QQWSSNPLT iv) DYNLN v) VINPNYGTTSYNQKFKG vi) GRDYFGY. A method of inhibiting angiogenesis in an individual in need thereof comprising administering the extracellular domain (residues 1-467) of MR, or a fragment thereof that inhibits angiogenesis, to the individual. A method of inhibiting endothelial cell migration and/or proliferation comprising administering the extracellular domain of MR, or a fragment thereof that inhibits endothelial cell migration and/or proliferation.
    Type: Application
    Filed: May 5, 2006
    Publication date: November 23, 2006
    Inventors: Roy Bicknell, Steven Suchting, Lorna Stewart
  • Antibodies binding to human magic roundabout (mr), polypeptides and uses thereof for inhibition angiogenesis
    Publication number: 20060099143
    Abstract: A method of inhibiting angiogenesis in an individual in need thereof comprising administering an antibody that selectively binds to the extracellular region of human magic roundabout (MR) to the individual. An antibody that has the amino acid sequences i) to iii), the amino acid sequences iv) to vi), or the amino acid sequences i) to vi): i) S A S S S V S Y M Y ii) L T S N L A S iii) Q Q W S S N P L T iv) D Y N L N v) V I N P N Y G T T S Y N Q K F K G vi) G R D Y F G Y. A method of inhibiting angiogenesis in an individual in need thereof comprising administering the extracellular domain (residues 1-467) of MR, or a fragment thereof that inhibits angiogenesis, to the individual. A method of inhibiting endothelial cell migration and/or proliferation comprising administering the extracellular domain of MR, or a fragment thereof that inhibits endothelial cell migration and/or proliferation.
    Type: Application
    Filed: November 20, 2003
    Publication date: May 11, 2006
    Inventors: Roy Bicknell, Steven Suchting, Lorna Stewart