Abstract: On-body analyte sensors may be designed for extended wear to provide ongoing measurement of physiological analyte levels. However, on-body analyte sensors may be susceptible to damage or dislodgment during wear due to routine interactions that occur with one's surroundings. Guard rings may be adapted to protect on-body analyte sensors from such interactions. Guard rings may comprise an annular body comprising an inner perimeter face, an outer perimeter face, a top edge, and a bottom face adapted for contacting a tissue surface. The inner perimeter face is shaped to circumferentially surround a sensor housing of an on-body analyte sensor. At least a portion of the outer perimeter face defines a chamfered surface extending between the top face and the bottom face. Adhesive pads or strips may further be engaged with the guard rings and aid in securing the guard rings to a surface, such as skin.

Abstract: Recyclable analyte monitoring devices are provided. For example, a tray may be use with an applicator for delivery of an analyte sensor. The tray may include a housing including a sensor carrier configured to secure a sensor control device within an interior of the applicator, a lid removably sealed to the housing to seal the interior of the housing until being removed just prior to use of the applicator to apply the sensor control device to a user's body, and a removable desiccant pouch including a silica gel enclosed by a vapor-permeable membrane. The desiccant pouch may be in fluid communication with an interior of the housing for humidity control.

Abstract: An analyte sensor and methods and systems related thereto, where at least one or more of a lower portion of a sensor tail substrate, at least one electrode, a sensing element, a membrane, and an optional non-electrochemical functional layer comprise an antimicrobial quality. Asymmetric, double-sided adhesive binders suitable for adhering the analyte sensor to a skin surface comprising a non-woven scrim, a first pressure-sensitive adhesive layer, a second pressure-sensitive adhesive layer. Overbandages comprising a vapor-permeable backing, an aperture to circumferentially surround a sensor housing, a contact adhesive layer, first and second peelable release liners, and a third peelable release liner disposed upon an anchoring adhesive strip of the contact adhesive layer.

Abstract: Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor for sensing an analyte level in a bodily fluid of a subject. In particular, disclosed herein are various embodiments of applicators, and components thereof, designed to reduce trauma to tissue of a sensor insertion site and to increase the likelihood of a successful sensor insertion. Also disclosed are embodiments to ensure structural integrity of a sensor.

Abstract: An assembly for insertion of an analyte sensor is provided. The assembly can include an applicator having an applicator housing, a sharp, a carrier configured to releasably retain a sensor control device, and an applicator cap removably coupled with the applicator housing. The assembly can further include a sensor control device configured to be worn on skin of a user, which includes a sensor control device housing, sensor electronics disposed in the sensor control device housing, the analyte sensor, a sensor cap, a collar configured to snap-fit into the sensor cap, an adhesive patch comprising a distally-facing surface configured to adhere to the skin of the user, and an adhesive liner. The adhesive liner can be configured such that removal of the applicator cap and/or the sensor cap causes removal of the adhesive liner from the adhesive patch.

Abstract: A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.

Abstract: A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.

Abstract: A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.

Abstract: An analyte measuring system including an enclosure comprising a top shell having an outer top-shell periphery and an inner top-shell periphery, and a mounting base having an outer mounting-base periphery: a circuit board disposed within the enclosure, the circuit board having a connector: an analyte sensor assembly configured to connect to the connector on the circuit board: wherein the outer top-shell periphery can be ultrasonically welded to the outer mounting-base periphery and the inner top-shell periphery can be ultrasonically welded to the inner mounting base periphery. A method for constructing of an analyte sensor and an enclosure for an analyte monitoring system are also disclosed.

Abstract: A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.

Abstract: An assembly for delivering an analyte sensor comprising a sensor control device. The sensor control device comprises an electronics housing with a shell having a first aperture and a first interface, and a mount having a second aperture and second interface, wherein the housing has an interior space. The two interfaces define a first sterile barrier. The housing also comprises a first mating member, a circuit board, and an analyte sensor. The assembly also comprises an applicator to deliver the sensor, and comprising a housing and a cap removably coupled to the housing to seal the applicator's interior, a sharp hub, and a second mating member extending within the first or second aperture, which mates with the first mating member to define a second sterile barrier. The sensor control device also comprises a collimator, a third sterile barrier, and a fourth sterile barrier which define a sterilization zone.

Abstract: Systems, devices and methods are provided for inserting at least a portion of a sensor for sensing an analyte level in a bodily fluid of a subject. In particular, disclosed herein are various embodiments of reset tools for resetting an insertion apparatus, and containers for storing an analyte monitoring assembly. The analyte monitoring assembly can be a combination of components used for monitoring an analyte of the subject. The containers described herein can be used to load an analyte monitoring assembly into an insertion apparatus. The insertion apparatus can then be used to insert at least a portion of the sensor into the subject's skin. The insertion apparatus can be reusable.

Abstract: Systems, devices, and methods are provided for inserting a sensor into skin of a subject. The insertion apparatus includes a sensor control device, a housing, and a guide for guiding insertion of a sensor into the skin. The housing may have an interface element, a cover, and a device carrier configured to releasably retain the sensor control device. The guide may be configured to support at least a portion of the sensor, and includes a retaining element. In a first configuration, the retaining element is configured to engage with the interface element to resist distal movement of the housing relative to the guide. In a second configuration, the interface element is configured to disengage from the retaining element to distally move the housing relative to the guide and insert the sensor into the skin.

Abstract: Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor for sensing an analyte level in a bodily fluid of a subject. In particular, disclosed herein are various embodiments of applicators, and components thereof, designed to reduce trauma to tissue of a sensor insertion site and to increase the likelihood of a successful sensor insertion.

Abstract: A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.

Abstract: A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.

Abstract: An analyte sensor and methods and systems related thereto, where at least one or more of a lower portion of a sensor tail substrate, at least one electrode, a sensing element, a membrane, and an optional non-electrochemical functional layer comprise an antimicrobial quality. Asymmetric, double-sided adhesive binders suitable for adhering the analyte sensor to a skin surface comprising a non-woven scrim, a first pressure-sensitive adhesive layer, a second pressure-sensitive adhesive layer. Overbandages comprising a vapor-permeable backing, an aperture to circumferentially surround a sensor housing, a contact adhesive layer, first and second peelable release liners, and a third peelable release liner disposed upon an anchoring adhesive strip of the contact adhesive layer.

Abstract: On-body analyte sensors may be designed for extended wear to provide ongoing measurement of physiological analyte levels. However, on-body analyte sensors may be susceptible to damage or dislodgment during wear due to routine interactions that occur with one's surroundings. Guard rings may be adapted to protect on-body analyte sensors from such interactions. Guard rings may comprise an annular body comprising an inner perimeter face, an outer perimeter face, a top edge, and a bottom face adapted for contacting a tissue surface. The inner perimeter face is shaped to circumferentially surround a sensor housing of an on-body analyte sensor. At least a portion of the outer perimeter face defines a chamfered surface extending between the top face and the bottom face. Adhesive pads or strips may further be engaged with the guard rings and aid in securing the guard rings to a surface, such as skin.