Patents by Inventor Steven T. Okino

Steven T. Okino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detecting methylation in a subpopulation of genomic DNA
    Patent number: 10683551
    Abstract: This invention provides methods of determining the biological, pathological, genetic, epigenetic or disease status in a biological sample by determining the methylation status of a subpopulation of genomic DNA in the sample.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: June 16, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Steven T. Okino, Yan Wang
  • Filtering small nucleic acids using permeabilized cells
    Patent number: 9752177
    Abstract: Filtering small nucleic acids using permeabilized cells and methods for using the filtering to detect genomic DNA accessibility are described.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: September 5, 2017
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Yanhong Kong, Steven T. Okino, Xiangdong Meng
  • DETECTING METHYLATION IN A SUBPOPULATION OF GENOMIC DNA
    Publication number: 20170159132
    Abstract: This invention provides methods of determining the biological, pathological, genetic, epigenetic or disease status in a biological sample by determining the methylation status of a subpopulation of genomic DNA in the sample.
    Type: Application
    Filed: January 20, 2017
    Publication date: June 8, 2017
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: Steven T. OKINO, Yan WANG
  • METHODS FOR DETECTING NUCLEIC ACIDS PROXIMITY
    Publication number: 20160273027
    Abstract: The present invention provides methods for determining whether two or more nucleic acid molecules or two or more regions of a nucleic acid molecule in a sample are in close proximity to each other due to direct or indirect physical interactions.
    Type: Application
    Filed: November 21, 2014
    Publication date: September 22, 2016
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: Steven T. OKINO, Man CHENG
  • FILTERING SMALL NUCLEIC ACIDS USING PERMEABILIZED CELLS
    Publication number: 20160208312
    Abstract: Filtering small nucleic acids using permeabilized cells and methods for using the filtering to detect genomic DNA accessibility are described.
    Type: Application
    Filed: April 18, 2014
    Publication date: July 21, 2016
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: Yanhong Kong, Steven T. Okino, Xiangdong Meng
  • FILTERING SMALL NUCLEIC ACIDS USING PERMEABILIZED CELLS
    Publication number: 20140220586
    Abstract: Filtering small nucleic acids using permeabilized cells and methods for using the filtering to detect genomic DNA accessibility are described.
    Type: Application
    Filed: April 18, 2014
    Publication date: August 7, 2014
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: Yanhong Kong, Steven T. Okino, Xiangdong Meng
  • Filtering small nucleic acids using permeabilized cells
    Patent number: 8728987
    Abstract: Filtering small nucleic acids using permeabilized cells and methods for using the filtering to detect genomic DNA accessibility are described.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: May 20, 2014
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Yanhong Kong, Steven T. Okino, Xiangdong Meng
  • Stabilized protease-containing solutions for purifying RNA-free DNA
    Patent number: 8652821
    Abstract: The present invention provides compositions and methods for purifying RNA-free DNA from a sample.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: February 18, 2014
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Steven T. Okino, Yan Wang
  • FILTERING SMALL NUCLEIC ACIDS USING PERMEABILIZED CELLS
    Publication number: 20130035239
    Abstract: Filtering small nucleic acids using permeabilized cells and methods for using the filtering to detect genomic DNA accessibility are described.
    Type: Application
    Filed: August 2, 2012
    Publication date: February 7, 2013
    Applicant: Bio-Rad Laboratories
    Inventors: Yanhong Kong, Steven T. Okino, Xiangdong Meng
  • DETECTING METHYLATION IN A SUBPOPULATION OF GENOMIC DNA
    Publication number: 20120208193
    Abstract: This invention provides methods of determining the biological, pathological, genetic, epigenetic or disease status in a biological sample by determining the methylation status of a subpopulation of genomic DNA in the sample.
    Type: Application
    Filed: February 14, 2012
    Publication date: August 16, 2012
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: Steven T. Okino, Yan Wang
  • PCR FOR DNA THAT IS RESISTANT TO AMPLIFICATION
    Publication number: 20120122158
    Abstract: DNA that is difficult to amplify by conventional PCR is amplified by a modified PCR process that includes a high-temperature, short-term heating step as the last step of each thermal cycle, following the conventional denaturing and annealing/elongation steps.
    Type: Application
    Filed: May 17, 2011
    Publication date: May 17, 2012
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: Steven T. Okino, Yanhong Kong
  • STABILIZED PROTEASE-CONTAINING SOLUTIONS
    Publication number: 20120100597
    Abstract: The present invention provides compositions and methods for purifying RNA-free DNA from a sample.
    Type: Application
    Filed: October 19, 2011
    Publication date: April 26, 2012
    Applicant: Bio-Ras Laboratories, Inc.
    Inventors: Steven T. Okino, Yan Wang