Abstract: The present disclosure relates to non-natural NKG2D receptors attached to mammalian cell surfaces wherein the non-natural receptors do not directly signal or directly activate the cell when the receptor is bound by cognate non-natural ?1-?2 domains of NKG2D ligands modified to specifically bind the non-natural NKG2D receptors. The non-natural ?1-?2 domains of NKG2D ligands may be attached to heterologous atoms or molecules including polypeptides, in some embodiments cytokines or modified cytokines, antibodies or fragments of antibodies.

Abstract: The present disclosure relates to novel sialidase enzymes having a preference for cleaving N-glycolylneuraminic acid (Neu5Gc) from glycoconjugates over cleaving N-acetyineuraminic acid (Neu5Ac). The present disclosure further provides the polypeptide of such novel sialidase and its catalytic pockets; the recombinant host cells expressing the same, as well as the enzymatic, pharmaceutical, and consumable compositions comprising such novel sialidases. Probiotic compositions comprising a bacterium that expresses the sialidase having a preference for Neu5Gc over Neu5Ac, and methods for removing Neu5Gc from consumable products are also provided. Also disclosed are methods for treating or preventing various diseases, disorders, and inflammatory conditions in a subject using the novel sialidases.

Abstract: Methods and systems provided. A system may include a mobile surveillance unit positioned within an environment and including one or more sensors configured to detect one or more events occurring within or near the environment. The system may also include an application program configured to: convey data related to a detected event of the one or more events to an electronic device remote from the mobile surveillance unit; and in response to input associated with the detected event, convey, from the mobile surveillance unit, image data, video data, audio data, or any combination thereof, previously captured at the mobile surveillance unit and associated with the detected event.

Abstract: A fire pit includes an engine having at least one wall defining an inner chamber. At least one primary air aperture is defined through the inner chamber wall at a first, lower level, and at least one secondary air aperture is defined through the inner chamber wall at a second, upper level. A fuel grate is supported within the inner chamber at a level between the lower level and the upper level.

Abstract: An induction rotor assembly having conductive bars is provided. The assembly comprises a lamination stack comprising a body having a first end and second ends to define a longitudinal axis. The body has an outer circumferential portion extending from the first end to the second end. The outer portion has a plurality of walls defining open slots formed from the first end through the second end. The assembly further comprises a first ring disposed on the first end and a second ring disposed on the second end. The assembly further comprises a plurality of conductive bars extending between the first and second rings. Each conductive bar is disposed in one of the slots such that the respective conductive bar is in contact with the lamination stack and connects the first and second rings. Each bar comprises an inner portion and a conductive outer skin disposed about the inner portion.

Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included having a graphene varactor including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through non-covalent interactions between the self-assembled monolayer and a ?-electron system of graphene. The self-assembled monolayer includes one or more pillarenes, substituted pillarenes, calixarenes, substituted calixarenes, peralkylated cyclodextrins, substituted peralkylated cyclodextrins, pyrenes, or substituted pyrenes, or derivatives thereof. Other embodiments are also included herein.

Abstract: Embodiments described herein relate to formulations for and methods of use for eye drop formulations comprising carboxymethyl cellulose (CMC) and hyaluronic acid (HA) with an improved distribution on the cornea during blinking.

Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R5 and X are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds for the treatment or prevention of acute neurological disorders, chronic neurological disorders and/or cognitive disorders.

Abstract: A bubble trap includes a body having an interior surface bounding a cavity that extends between an upper end and an opposing lower end, an axis extends centrally through the cavity of the body between the upper end and the lower end, a first plane extends through the body orthogonal to the axis so as to divide the body into an upper body portion and a lower body, the interior surface of the lower body portion having a constant first radius from a fixed first center point, the interior surface of the upper body portion not having a constant radius from a fixed center point. A tubular spout projects into the cavity at the lower end encircles a channel that communicates with the cavity. A liquid inlet port, a liquid outlet port, and a gas outlet port communicate with the cavity.

Abstract: Techniques for improved efficiency of sintering in additive fabrication are described. According to some aspects, mechanisms for depositing and leveling source material are combined with a mechanism for heating the material. In some embodiments, one or more heating elements may be arranged to lead and/or follow a material deposition mechanism such that heat may be applied to the build region in concert with deposition of material. As a result of this technique, the heating and depositing steps may be performed closer together in time and/or heat may be applied more directly to the material than in conventional systems. As a result, greater control over material temperature may be achieved, thereby avoiding excess temperature exposure and subsequent undesirable changes to the material.

Abstract: Described are methods, systems, and techniques for a laser system controller, such as a controller for a laser used in a medical device. The controller can be configured to generate a pulse-width modulated control signal, the pulse-width modulated control signal comprising a plurality of electrical pulses separated by a temporal delay; and communicating the pulse width modulated control signal to an optical pump, wherein the optical pump, responsive to the pulse width modulated control signal, generates optical pump light and wherein a lasing medium, when exposed to the optical pump light, generates a laser beam.

Abstract: A method of diverting fluid flow from a first vessel including an occlusion to a second vessel includes deploying a prosthesis at least partially in a fistula and making valves in the second vessel incompetent. Making the valves in the second vessel incompetent includes at least one of using a reverse valvulotome to cut the valves, inflating a balloon, expanding a stent, and lining the second vessel with a stent.

Abstract: An artificial neural network (ANN) modelled as an overlay hypergraph comprising a plurality of hyperedges, a plurality of role nodes, and one or more overlay nodes. A hyperedge of the plurality of hyperedges represents an artificial neuron within the ANN and comprises a set of role nodes each of which representing a portion of a connective relationship within the ANN. A role node of the plurality of role nodes represents a connection between layers of the ANN and comprises a first connective relationship associated with a first hyperedge and a second connective relationship associated with a second hyperedge such that the role node functionally connects the first hyperedge and the second hyperedge. The one or more overlay nodes comprise processing logic operable to interact with at least one hyperedge or at least one role node coupled to the one or more overlay nodes.

Abstract: A surgical stapler is provided that includes a spring loaded lift that automatically adjusts a staple cartridge and/or staple formation between a range of sizes. The lift is automatically released as the staple firing mechanism begins its forward translation of the firing sequence. The automatic one-way adjustment also adjusts the staple cartridge while maintaining the cartridge parallel to the anvil to provide consistent staple formations.

Abstract: Techniques for ensuring that geographic location specific security policies are enforce for an agent or agent device. An Agent service of an agent device accesses an Agent Authentication Service for a key to initiate one or more functions of the agent device. The Agent Authentication Service determines the location of the agent device and determines whether the agent device is within an approved geographic location based on geographic location specific security policies. If the agent device is within the approved geographic location, the Agent Authentication Services accesses a Key Management Service for a cryptographic key and delivers the cryptographic key to the Agent. If the Agent Authentication Service determines that the Agent device is outside of the approved location, access to the cryptographic key is denied.

Abstract: Concepts presented herein relate to use of one or more vehicles in planting and growing crops. In some embodiments, the vehicles can operate autonomously or semi-autonomously. During use, the vehicles can apply seeds for planting and further apply agricultural inputs to a crop after planting.

Abstract: The present invention provides acyl sulfonamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients as well as methods of treatment and/or prophylaxis of diseases, particularly cancer, more particularly cancer in which KAT6A and/or KAT6B is focally amplified, said method comprising administering an effective amount of at least one compound of formula (I) to a subject in need thereof.

Abstract: Combination therapies comprising administering radioimmunoconjugates and one or more checkpoint inhibitors.

Abstract: Apparatuses, systems, and techniques to perform an application programming interface (API) to add one or more graph nodes to a software graph, wherein the API is to store an indication of whether a node within a software graph was performed based, at least in part, on a dependency type indicated by the API. In at least one embodiment, one or more nodes are added to a graph in accordance to one or more dependency types.

Abstract: An overlay system is provided that includes a primary storage element, a plurality of auxiliary storage elements, and processing circuitry. The primary storage element stores an executable graph-based model having a plurality of nodes. The processing circuitry receives a first stimulus indicative of a data splintering instruction. Based on the first stimulus, the processing circuitry identifies a first node in the executable graph-based model and executes a data splintering operation on the first node to divide the first node into a plurality of splinters. The processing circuitry, based on the first stimulus, instantiates a plurality of location overlay nodes and associates the plurality of location overlay nodes with the plurality of splinters. Based on the association, the processing circuitry stores each splinter of the plurality of splinters in an auxiliary storage element indicated by a corresponding location overlay node.