Abstract: Genetically modified mice and methods for making an using them are provided, wherein the mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene segments, D gene segments, and J gene segments with at least one light chain V gene segment and at least one light chain J gene segment. Mice that make binding proteins that comprise a light chain variable domain operably linked to a heavy chain constant region are provided. Binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Modified cells, embryos, and mice that encode sequences for making the binding proteins are provided.

Abstract: A self-contained starting module for outdoor power equipment that has control circuit and a start button. The starting module includes internal control circuit that can be either microprocessor based or analog. The control circuit receives a start signal from a start button of the starting module. The control circuit monitors for the presence of an enable device and, upon activation of the start button and the presence of the enable device, provides electric power to the electric load of the power equipment. When the start button is depressed for longer than a minimum engagement period, the control circuit initiates operation of the engine. If the start button is pressed for less than the minimum engagement period, the control circuit activates the electric load for an auxiliary period without starting the engine. During engine operation, if the start button is depressed, the operation of the engine is terminated.

Abstract: An apparatus (14) for installation and removal of electronic components (10) for a tire comprises an expansion device (16) having a plurality of movably supported longitudinal prongs (18), wherein the expansion device (16) is adapted for moving at least a part of the plurality of prongs (18) between a neutral position with a least distance between the prongs (18) and at least one expansion position with a distance between the prongs (18) exceeding the least distance. The prongs (18) comprise prong tips (20), which each comprise a curved engagement surface (22), wherein each prong is adapted for engaging an exposed top lip (8) of an elastic container (2), in which the electronic component (10) is storable. The expansion device (16) is adapted for moving at least a part of the plurality of prongs (18) to an expansion position with the engagement surfaces (22) engaging the top lip (8) of the container (2), in which expansion position the top lip (8) is expanded.

Abstract: A computer system may perform substitutions for fields in a set of records, where performing a given substitution involves replacing a field in the set of records with a replacement field, and the substitutions remove the context information in the set of records while maintaining relevance of the set of records. Then, the computer system may generate an artificial set of records based, at least in part, on the set of records, where a given artificial record includes one or more modified portions of the set of records. Next, the computer system may combine the set of records and the artificial set of records into a second set of records, where at least some phrases or values in the second set of records are uniformly distributed.

Abstract: The present invention is directed to a coating composition or paint comprising a multistage latex with at least first and second stages, wherein the composition or paint is substantially free of volatile organic compounds (VOC) and capable of film formation even in the absence of coalescent agents. The base paint formulation is capable of being tinted at a point-of-sale (i.e. in-store) using a colorant composition of a type and quantity required to produce a paint of desired color and finish. The paints, including deeply colored paints, show improved block resistance, scrub resistance and tack resistance.

Abstract: The method generally involves the steps of filling the cavities in a production tool each with an individual abrasive particle. Aligning a filled production tool and a resin coated backing for transfer of the abrasive particles to the resin coated backing. Transferring the abrasive particles from the cavities onto the resin coated backing and removing the production tool from the aligned position with the resin coated backing. Thereafter the resin layer is cured, a size coat is applied and cured and the coated abrasive article is converted to sheet, disk, or belt form by suitable converting equipment.

Abstract: Optical connector arrangements terminate at least seventy-two optical fibers. The optical connector arrangements include multiple optical ferrules that each terminates multiple optical fibers. Some example optical connectors can terminate about 144 optical fibers. Each optical connector includes a fiber take-up arrangement and a flange extending outwardly from a connector housing arrangement. The fiber take-up arrangement manages excess length of the optical fibers. A threadable coupling nut can be disposed on the connector housing arrangement to engage the outwardly extending flange. Certain types of optical connector arrangements include furcation cables spacing the connector housing arrangement form the fiber take-up arrangement.

Abstract: A lid may be sized and configured to be attached to a container and the lid may include a spout and a flip-top closure. The flip-top closure may be movable between open and closed positions relative to the spout. The lid may also include a carrying member with a loop-shaped configuration. The lid may further include one or more flanges and the flanges may include one or more protrusions. The protrusions may form a pivot point about which the flip-top closure pivots between the open and closed positions. The protrusions may also allow the carrying member to pivot independently of the flip-top closure.

Abstract: Genetically modified mice and methods for making an using them are provided, wherein the mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene segments, D gene segments, and J gene segments with at least one light chain V gene segment and at least one light chain J gene segment. Mice that make binding proteins that comprise a light chain variable domain operably linked to a heavy chain constant region are provided. Binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Modified cells, embryos, and mice that encode sequences for making the binding proteins are provided.

Abstract: A knee brace with a connection mechanism that enables quick and easy secure attachment and detachment of a plastic cuff shell to struts of the brace without the need for separate fasteners and the tools required for them via the use of a novel snap connector which will connect by a simple plug in motion, and which is configured to firmly hold the connected strut and prevent it from rotating relative to the cuff shell once connected while also enabling a quick and easy tool-free disconnection of the strut for exchanging of one cuff for another. The thigh and tibia shells can be interchange without removing any screws, rivets or traditional connectors providing a modular construction with the ability to mix and match different size thigh and calf shells, making it possible for a customer to order the product in kit form, or as separate components thereby enabling easy customization.

Abstract: An output shaft of a transmission is fixed to a planetary gearset carrier. Output torque is measured via a surface acoustic wave sensor affixed to a face of the carrier between two adjacent planet gears and radially inside a weld joining the carrier face to an opposite carrier face. In this location, the level of strain at typical transmission output torques produces a level of strain within the measuring range of a surface acoustic wave sensor. The sensor may be powered and signals communicated across an air gap defined by signal rings. Due the stable position and orientation of the carrier, a small, consistent air gap is possible.

Abstract: A dampening fluid useful in offset ink printing applications contains water and a surfactant whose structure can be altered. The alteration in structure aids in reducing accumulation of the surfactant on the surface of an imaging member. The surfactant can be decomposed, switched between cis-trans states, or polymerizable with ink that is subsequently placed on the surface.

Abstract: A vehicle system includes communication circuitry programmed to communicate with a controller that is removable from an autonomous vehicle. The system further includes a processor programmed to receive control signals, which are associated with manually controlling the autonomous vehicle in a non-autonomous mode, transmitted from the controller. The processor is further programmed to output commands to at least one vehicle subsystem in accordance with the control signals transmitted from the controller while the vehicle is operating in a non-autonomous mode.

Abstract: One embodiment describes a quantum memory system. The system includes an array controller that comprises a plurality of flux pumps configured to provide write currents in a write operation and read currents in a read operation with respect to a plurality of quantum memory cells, the array controller being configured to control timing associated with the write operation and the read operation in response to memory request signals based on application of the write currents and the read currents and based on recharging flux associated with the plurality of flux pumps.

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: Various embodiments are described herein for controlling the self-assembly process of paramagnetic particles and the final particle cluster size using a liquid-liquid interface. The number of paramagnetic particles within a particle cluster and coating at the liquid-liquid interface may be controlled by systematically varying the strength of an applied magnetic field gradient and the interfacial tension of the liquid-liquid interface.

Abstract: A cooler including a compartment, a conduit including a first end portion configured to be in communication with the compartment and a second end portion, food product at a first product temperature entering the first end portion, a fluid discharge positioned substantially within the conduit between the first end portion and the second end portion, and a pressurized fluid source in communication with and for supplying fluid through the fluid discharge, the fluid being at a first fluid temperature less than the first product temperature, the pressurized fluid source being operable to propel the fluid through the fluid discharge to move the food product from the first end portion of the conduit toward the second end portion and to cool the food product to a temperature below the first product temperature.

Abstract: Various systems and methods are disclosed herein to increase the quality of the sound and intelligibility of speech delivered to a user by combining electric audio signals from more than one hearing assistance device that incorporates an active signal enhancement system. The method includes receiving electric audio signals at a first hearing assistance device, and sending electric audio signals to a second hearing assistance device. The electric audio signal is encoded as a replacement for input to an microphone channel located at the second hearing assistance device. The electric audio signals from the microphone located at the first hearing assistance device and the microphone located at the second hearing assistance device are combined. The combined electric audio signals are processed through a digital signal processor in the first hearing assistance device to enhance the amplitude of the desired signal via constructive interference.

Abstract: A network management application receives input from a subscriber operating a computer device to add a new wireless access point to a network environment. The input specifies a geographical location in which the subscriber requests installation of the new wireless access point in the network environment. The network management application produces a message to include the geographical location as specified by the input. The message indicates that the subscriber requests installation of the new wireless access point at the geographical location. The network management application initiates transmission of the message from the computer device to an aggregator resource at a remote location. A service provider analyzes installation request information produced by the aggregator resource to determine where to install one or more new wireless access points in the network environment.

Abstract: An electronic device comprises a display and a 360° variable planar panoramic video controller to present on the display a capture screen to guide the user to capture a near-seamless 360° panoramic video image. Simultaneously with the completion of the video capture, a 360° panoramic zoetropic video image is assembled from still images selected at intervals during the 360° continuous directional physical rotation of the electronic capture device.