Abstract: Described herein are compounds of Formula I: and their pharmaceutically acceptable salts, wherein R1, R2, R3, L1, T1, T2, T3, T4, t1, and t2 are defined herein; their use as GIPR antagonists; pharmaceutical compositions containing such compounds and salts; and the use of such compounds and salts to treat or prevent, for example, obesity, weight gain, and/or T2DM.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g.

Abstract: Described herein are 3-fluoro-4-hydroxybenzamide-containing inhibitors and/or degraders, and pharmaceutical compositions containing 3-fluoro-hydroxybenzamide-containing inhibitors and/or degraders. In some embodiments, the 3-fluoro-4-hydroxybenzamide-containing compounds of the disclosure can be used to treat a condition, for example, nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, NAFLD and NASH.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g.

Abstract: This disclosure relates to pole bases, specifically to light pole base cabinets that can house items. The pole base cabinets can be positioned between a light pole and a footing. The pole base cabinets provide a base to a light pole while adding additional functionality. The cabinets can include a main opening allowing access to a cavity in which items can be stored. Access to the cavity can be restricted with a door that uncovers and covers the main opening. The pole base cabinets can include support panels, internal stiffening panels, external stiffening panels, support tabs, flanges, tabs, a peripheral wall, and other features to provide structural support and enclose the contents in the pole base cabinet.

Abstract: A method includes machining a raw surface of a metal component to remove first native oxide from a metal base of the metal component to generate an as-machined surface of the metal component. A second native oxide is formed on the metal base of the as-machined surface of the metal component subsequent to the machining. The method further includes, subsequent to the machining, performing operations to generate a finished surface of the metal component. The operations include a surface machining of the as-machined surface of the metal component to remove the second native oxide.

Abstract: Provided are private networks for peer-to-peer financial transactions and value transfers comprising, for each peer-to-peer financial transaction, an electronic document comprising at least the core terms of the peer-to-peer financial transactions; a unique identifier for that transaction; the identities of each party involved in the transaction; an authorization approval section for the document that requires use of the signing key unique to a party authorizing the transaction; and a timestamp corresponding to the time a party authorized the transaction.

Abstract: This disclosure relates to a housing that can be coupled to a pole base cabinet. The housing can include a first end that can be coupled to the pole base cabinet. The first end can include an opening. The housing can include a second end opposite the first end that is closed. The housing can include a wall extending between the first and the second ends. The wall can include a front face and surround a cavity. The cavity can be accessible by way of the opening. The housing can include a protrusion disposed on the front face. The protrusion can include two angled surfaces for EV chargers.

Abstract: Methods and systems for using blockchain digital currency are provided herein. The methods and systems comprise a blockchain digital currency that is created and utilized on a permission-based network of financial institutions. The blockchain digital currency is created by a central authority and minted into circulation by banks within the network, and is backed by reserves of real world currency of any country. The digital currency can be used for any type of financial transaction, and the system provides security, trust, traceability and a detailed audit trail for all transactions.

Abstract: A networking router process, by a hardware data plane, a first incoming packet by matching the packet with a routing table of the hardware data plane. A software data plane processes a second incoming packet by matching the packet with a routing table of the software data plane. In response to the processing of the first incoming packet by the hardware data plane failing, subsequently processing, by the software data plane, the first incoming packet by matching the packet with the routing table of the software data plane. The method comprises delivering, from the software and hardware data plane, network traffic flow information to a flow analyzer. The flow analyzer analyzes the network traffic flow information and updates at least one of the routing tables based at least on the analyzed network traffic flow information.

Abstract: This disclosure relates to pole bases, specifically to light pole base cabinets that can house items. The pole base cabinets can be positioned between a light pole and a footing. The pole base cabinets provide a base to a light pole while adding additional functionality. The cabinets can include a main opening allowing access to a cavity in which items can be stored. Access to the cavity can be restricted with a door that uncovers and covers the main opening. The pole base cabinets can include support panels, internal stiffening panels, external stiffening panels, support tabs, flanges, tabs, a peripheral wall, and other features to provide structural support and enclose the contents in the pole base cabinet.

Abstract: A method includes machining a raw surface of a metal component to remove first native oxide from a metal base of the metal component to generate an as-machined surface of the metal component. A second native oxide is formed on the metal base of the as-machined surface of the metal component subsequent to the machining. The method further includes, subsequent to the machining, performing operations to generate a finished surface of the metal component. The operations include a surface machining of the as-machined surface of the metal component to remove the second native oxide.

Abstract: A method includes receiving a metal component including a raw surface that includes a metal base, a first native oxide disposed on the metal base, and hydrocarbons disposed on the metal base. The method further includes machining the raw surface of the metal component to remove the first native oxide and a first portion of the hydrocarbons from the metal base. The machining generates an as-machined surface of the metal component including the metal base without the first native oxide and without the first portion of the hydrocarbons. The method further includes performing a surface machining of the as-machined surface of the metal component to remove a second portion of the hydrocarbons. The method further includes surface treating the metal component to remove a third portion of the hydrocarbons. The method further includes performing a cleaning of the metal component and drying the metal component.

Abstract: A system includes a heat exchanger mounted to the brackets and receiving cryogen, the heat exchanger having a vertical inlet coupled in parallel to a plurality of equal size horizontal tubes each traversing a width of the heat exchanger and further coupled in parallel to a vertical outlet pipe with an outlet diameter at least twice an inlet tube diameter; a temperature sensor; a thermostat that monitors the temperature sensor and maintains a predetermined temperature set point by communicating with a solenoid valve coupled to the heat exchanger; an exhaust line coupled to the outlet pipe that expels exhaust gas outside the enclosed facility; multiple fans attached to the heat exchanger; and a fail-safe oxygen sensor to protect a biological object in the enclosed facility.

Abstract: A networking router process, by a hardware data plane, a first incoming packet by matching the packet with a routing table of the hardware data plane. A software data plane processes a second incoming packet by matching the packet with a routing table of the software data plane. In response to the processing of the first incoming packet by the hardware data plane failing, subsequently processing, by the software data plane, the first incoming packet by matching the packet with the routing table of the software data plane. The method comprises delivering, from the software and hardware data plane, network traffic flow information to a flow analyzer. The flow analyzer analyzes the network traffic flow information and updates at least one of the routing tables based at least on the analyzed network traffic flow information.

Abstract: A system includes a heat exchanger mounted to the brackets and receiving cryogen, the heat exchanger having a vertical inlet coupled in parallel to a plurality of equal size horizontal tubes each traversing a width of the heat exchanger and further coupled in parallel to a vertical outlet pipe with an outlet diameter at least twice an inlet tube diameter; a temperature sensor; a thermostat that monitors the temperature sensor and maintains a predetermined temperature set point by communicating with a solenoid valve coupled to the heat exchanger; an exhaust line coupled to the outlet pipe that expels exhaust gas outside the enclosed facility; multiple fans attached to the heat exchanger; and a fail-safe oxygen sensor to protect a biological object in the enclosed facility.

Abstract: This disclosure relates to pole bases, specifically to light pole base cabinets that can house items. The pole base cabinets can be positioned between a light pole and a footing. The pole base cabinets provide a base to a light pole while adding additional functionality. The cabinets can include a main opening allowing access to a cavity in which items can be stored. Access to the cavity can be restricted with a door that uncovers and covers the main opening. The pole base cabinets can include support panels, internal stiffening panels, external stiffening panels, support tabs, flanges, tabs, a peripheral wall, and other features to provide structural support and enclose the contents in the pole base cabinet.

Abstract: A coating composition includes: (a) a phosphorus acid functional polyol polymer having an acid value within a range of greater than 7 mg KOH/g and 33 mg KOH/g or less, and a hydroxyl value within a range of from 60 to 200 mg KOH/g; (b) an aminoplast derived crosslinker reactive with the phosphorus acid functional polyol polymer; and (c) a non-aqueous liquid medium. Further, if an external catalyst is present, the coating composition comprises less than 0.25 weight % of the external catalyst based on the total weight of the coating composition. The coating composition cures at a temperature of 100° C. or less.

Abstract: This disclosure relates to pole bases, specifically to light pole base cabinets that can house items. The pole base cabinets can be positioned between a light pole and a footing. The pole base cabinets provide a base to a light pole while adding additional functionality. The cabinets can include a main opening allowing access to a cavity in which items can be stored. Access to the cavity can be restricted with a door that uncovers and covers the main opening. The pole base cabinets can include support panels, internal stiffening panels, external stiffening panels, support tabs, flanges, tabs, a peripheral wall, and other features to provide structural support and enclose the contents in the pole base cabinet.