Abstract: A gonioscopic attachment can attach to a gonioscope and can include atraumatic retention elements that are configured to engage an eye to retain the gonioscope relative to the eye. The gonioscopic attachment can be configured to position the gonioscope so that at least a portion of the concave distal surface of the gonioscopic optical element is spaced apart from the eye, and/or so that the curvature of the distal surface is angularly offset from the curvature of the eye. The gonioscope can include a fixation point configured to be visible to the subject when the gonioscope is positioned on the eye. In some embodiments, the retention elements can be incorporated directly into the gonioscope. A coupling mechanism can couple the gonioscope to a lid speculum. The gonioscope can include a light pipe, which can be configured to directly light into the eye.

Abstract: Compounds or their pharmaceutically acceptable salts can inhibit the G12D mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: A technique facilitates formation of perforations into a formation surrounding a borehole in a manner which enhances fluid flow along the perforations. The technique comprises providing a plurality of perforating charges which may be detonated in the borehole to create perforations. The detonation is used to initiate a time delay device for controlling a subsequent detonation of a corresponding charge. The corresponding charge is used to create a pressure underbalance in the borehole. This relatively lower pressure in the borehole is selectively established to create a reverse flow through the perforations which cleans the perforations.

Abstract: A shaped charge includes a charge case; a liner; an explosive retained between the charge case and the liner; and a primer core disposed in a hole in the charge case and in contact with the explosive, wherein at least one of the case, the liner, the primer core, and the explosive comprising a material soluble in a selected fluid. A perforation system includes a perforation gun, comprising a gun housing that includes a safety valve or a firing valve, wherein the safety valve or the firing valve comprises a material soluble in a selected fluid.

Abstract: A technique facilitates formation of perforations into a formation surrounding a borehole in a manner which enhances fluid flow along the perforations. The technique comprises providing a plurality of perforating charges which may be detonated in the borehole to create perforations. The detonation is used to initiate a time delay device for controlling a subsequent detonation of a corresponding charge. The corresponding charge is used to create a pressure underbalance in the borehole. This relatively lower pressure in the borehole is selectively established to create a reverse flow through the perforations which cleans the perforations.

Abstract: A shaped charge includes a charge case; a liner; an explosive retained between the charge case and the liner; and a primer core disposed in a hole in the charge case and in contact with the explosive, wherein at least one of the case, the liner, the primer core, and the explosive comprising a material soluble in a selected fluid. A perforation system includes a perforation gun, comprising a gun housing that includes a safety valve or a firing valve, wherein the safety valve or the firing valve comprises a material soluble in a selected fluid.

Abstract: A shaped charge includes a charge case; a liner; an explosive retained between the charge case and the liner; and a primer core disposed in a hole in the charge case and in contact with the explosive, wherein at least one of the case, the liner, the primer core, and the explosive comprising a material soluble in a selected fluid. A perforation system includes a perforation gun, comprising a gun housing that includes a safety valve or a firing valve, wherein the safety valve or the firing valve comprises a material soluble in a selected fluid.

Abstract: A ballistic transfer delay device and method of use. The ballistic transfer delay device does not include a firing pin and it is not pressure initiated. The device comprises a time delay fuse, a through-bulkhead initiator to initiate the time delay fuse, and an output booster to ballistically transfer the energy from the initiated time delay fuse.

Abstract: A shaped charge includes a charge case; a liner; an explosive retained between the charge case and the liner; and a primer core disposed in a hole in the charge case and in contact with the explosive, wherein at least one of the case, the liner, the primer core, and the explosive comprising a material soluble in a selected fluid. A perforation system includes a perforation gun, comprising a gun housing that includes a safety valve or a firing valve, wherein the safety valve or the firing valve comprises a material soluble in a selected fluid.

Abstract: A perforating gun includes a plurality of shaped charges located at a first distance from a detonator along a plurality of detonating cords and forming a first group, wherein the first group of shaped charges is configured to be detonated simultaneously. The plurality of detonating cords are of the same length.

Abstract: A ballistic transfer delay device and method of use. The ballistic transfer delay device does not include a firing pin and it is not pressure initiated. The device comprises a time delay fuse, a through-bulkhead initiator to initiate the time delay fuse, and an output booster to ballistically transfer the energy from the initiated time delay fuse.

Abstract: A detonating device includes a high explosive portion comprising high explosive; a low explosive portion comprising low explosive; and a transition portion between the high explosive portion and the low explosive portion, wherein the transition portion comprises a mixture of high explosive and low explosive.

Abstract: A detonating device includes a high explosive portion comprising high explosive; a low explosive portion comprising low explosive; and a transition portion between the high explosive portion and the low explosive portion, wherein the transition portion comprises a mixture of high explosive and low explosive.

Abstract: A shaped charge includes a charge case; a liner; an explosive retained between the charge case and the liner; and a primer core disposed in a hole in the charge case and in contact with the explosive, wherein at least one of the case, the liner, the primer core, and the explosive comprising a material soluble in a selected fluid. A perforation system includes a perforation gun, comprising a gun housing that includes a safety valve or a firing valve, wherein the safety valve or the firing valve comprises a material soluble in a selected fluid.

Abstract: An apparatus that is usable with a well includes a perforating system that is adapted to be fired downhole in the well. The perforating system includes a component, which includes an alloy that has a negative corrosion potential and is unable to passivate, or self-protect, while deployed in the well. The component is adapted to disintegrate to form substantially no debris in response to the firing of the perforating system.

Abstract: An assembly that is usable with a well includes a base pipe, a screen and at least one perforating charge. The base pipe includes at least one radial port to communicate well fluid, and the base pipe has an outer surface. The screen is mounted to the base pipe and is adapted to at least partially surround the base pipe. The radial port(s) of the base pipe are covered by the screen. The perforating charge(s) are mounted to the outer surface of the base pipe.

Abstract: A technique that is usable with a well includes communicating a ballistic wave from a first point in a well to a second point in the well without propagating the ballistic wave along a detonating cord. The first and second points are separated by at least one foot. The technique includes responding to the ballistic wave near the second point to activate a downhole tool.

Abstract: An apparatus that is usable with a well includes a perforating system that is adapted to be fired downhole in the well. The perforating system includes a component, which includes an alloy that has a negative corrosion potential and is unable to passivate, or self-protect, while deployed in the well. The component is adapted to disintegrate to form substantially no debris in response to the firing of the perforating system.

Abstract: A method of dampening stress waves propagated from the detonation of an explosive device in a wellbore to protect a device positioned downhole including the steps of positioning a shock dissipater between an explosive device and a package; detonating the explosive device propagating a stress wave toward the shock dissipater and the package; and reflecting a portion of the stress wave in the shock dissipater. The shock dissipater may have one or more interface formed between materials of dissimilar acoustic impedances. The shock dissipater may reflect a compressive portion of the stress wave at one interface and a tensile portion of the stress wave at another interface.

Abstract: An integrated sandface completion tool that can be positioned within a wellbore in a single trip and a method of providing a sandface completion in a wellbore. An embodiment of the integrated sandface completion tool includes a casing section having a casing wall, at least one explosive charge connected to the casing wall, and a screen assembly connected within the casing section forming a screen-casing annulus, the screen assembly having openings formed along a portion thereof and a port in selective communication with the screen-casing annulus. The method includes the steps of positioning the integrated completion tool in the wellbore, detonating the explosive charge and packing the screen-casing annulus with a material.