Patents by Inventor Steven W. Metzger
Steven W. Metzger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9434937Abstract: Methods and systems for purifying cells and/or viruses are provided. The sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the cells and/or viruses in the well. The cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the cells and/or viruses may be retained in the well by embedding in the medium. The medium including the embedded cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface.Type: GrantFiled: March 7, 2012Date of Patent: September 6, 2016Assignee: ACCELERATE DIAGNOSTICS, INC.Inventors: Steven W. Metzger, Kenneth Robert Hance
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Publication number: 20160138067Abstract: Methods and systems for purifying cells and/or viruses are provided. The sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the cells and/or viruses in the well. The cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the cells and/or viruses may be retained in the well by embedding in the medium. The medium including the embedded cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface.Type: ApplicationFiled: January 21, 2016Publication date: May 19, 2016Applicant: Accelerate Diagnostics, Inc.Inventors: Steven W. Metzger, Kenneth Robert Hance
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Publication number: 20160010138Abstract: This disclosure is related to systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance.Type: ApplicationFiled: March 17, 2014Publication date: January 14, 2016Applicant: ACCELERATE DIAGNOSTICS, INC.Inventors: Alena Shamsheyeva, David Howson, Steven W. Metzger
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Publication number: 20150337351Abstract: The present disclosure is related to methods for immobilizing microorganisms to produce an immobilized microorganism sample for detection with a detection system. Compositions for immobilizing microorganisms are also disclosed.Type: ApplicationFiled: May 22, 2015Publication date: November 26, 2015Inventor: Steven W. Metzger
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Publication number: 20150225762Abstract: Generally provided are methods for rapid culture of microorganisms in a sample, including methods for growth and recovery of live microbial cells directly from a sample. Various features include enabling growth of microorganisms in a sample along with a reduction of sample debris that may interfere with microorganism detection, and reduction in toxicities that may inhibit microorganism growth. Further methods for selectively degrading non-viable microbial cells, are provided, for enhanced detection of viable microbial cells following a growth period.Type: ApplicationFiled: September 10, 2013Publication date: August 13, 2015Applicant: ACCELERATE DIAGNOSTICS, INC.Inventors: Steven W. Metzger, Kenneth Robert Hance, David C. Howson
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Patent number: 8895255Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: GrantFiled: February 8, 2013Date of Patent: November 25, 2014Assignee: Accelerate Diagnostics, Inc.Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Publication number: 20140323340Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: ApplicationFiled: July 11, 2014Publication date: October 30, 2014Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Publication number: 20140278136Abstract: This disclosure is related to systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: Accelerate Diagnostics, Inc.Inventors: Alena Shamsheyeva, David C. Howson, Steven W. Metzger
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Publication number: 20140038171Abstract: Methods and systems for purifying cells and/or viruses are provided. The sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the cells and/or viruses in the well. The cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the cells and/or viruses may be retained in the well by embedding in the medium. The medium including the embedded cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface.Type: ApplicationFiled: March 7, 2012Publication date: February 6, 2014Applicant: Accelerate Technology CorporationInventors: Steven W. Metzger, Kenneth Robert Hance
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Patent number: 8460887Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: GrantFiled: February 8, 2010Date of Patent: June 11, 2013Assignee: Accelerate Diagnostics, Inc.Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Publication number: 20120288717Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: ApplicationFiled: May 10, 2012Publication date: November 15, 2012Applicant: Accelr8 Technology CorporationInventors: Guoqiano Mao, Steven W. Metzger, Michael J. Lochhead
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Patent number: 8178602Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: GrantFiled: December 7, 2009Date of Patent: May 15, 2012Assignee: Accelr8 Technology CorporationInventors: Guoqiang Mao, Steven W. Metzger, Michael J. Lochhead
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Publication number: 20120077206Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.Type: ApplicationFiled: December 5, 2011Publication date: March 29, 2012Applicant: Accelr8 Technology CorporationInventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
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Patent number: 8071319Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.Type: GrantFiled: January 28, 2008Date of Patent: December 6, 2011Assignee: Accelr8 Technology CorporationInventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
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Publication number: 20100136570Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: ApplicationFiled: February 8, 2010Publication date: June 3, 2010Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Publication number: 20100081735Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: ApplicationFiled: December 7, 2009Publication date: April 1, 2010Applicant: Accelr8 Technology CorporationInventors: Guoqiano Mao, Steven W. Metzger, Michael J. Lochhead
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Patent number: 7687239Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: GrantFiled: July 8, 2004Date of Patent: March 30, 2010Assignee: Accelrs Technology CorporationInventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Patent number: 7629029Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: GrantFiled: October 13, 2004Date of Patent: December 8, 2009Assignee: Accelr8 Technology CorporationInventors: Guoqiang Mao, Steven W. Metzger, Michael J. Lochhead
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Patent number: 7501157Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: GrantFiled: January 13, 2005Date of Patent: March 10, 2009Assignee: Accelr8 Technology CorporationInventors: Guoqiang Mao, Steven W. Metzger, Michael J. Lochhead, David A. Goldberg, Charles H. Greef, David W. Grainger
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Publication number: 20080241858Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.Type: ApplicationFiled: January 28, 2008Publication date: October 2, 2008Inventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry