Abstract: A reactor system for pyrolysis of carbonaceous waste, a method of treating waste comprising carbonaceous waste by pyrolysis in the reactor system, and uses of particulate material in the reactor system and/or method, are provided. The reactor system comprises a fluidised bed pyrolysis reactor. The fluidised bed pyrolysis reactor comprises a shell defining a heating chamber, the heating chamber having a fluidised bed zone configured to contain a fluidised bed of particulate material comprising particulate material susceptible to inductive heating. The reactor system also comprises a pyrolysis induction heater assembly comprising an induction emitter configured to inductively heat the particulate material. The shell of the reactor is made from an inductively inert material.

Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence and kits and devices for use in said methods. The methods employ restriction enzymes, polymerase and oligonucleotide primers to produce an amplification product in the presence of a target nucleic acid, which is contacted with oligonucleotide probes to produce a detector product.

Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence and kits and devices for use in said methods. The methods employ restriction enzymes, polymerase and oligonucleotide primers to produce an amplification product in the presence of a target nucleic acid, which is contacted with oligonucleotide probes to produce a detector product.

Abstract: The present invention provides systems and methods for detecting bacterial infection in a patient sample in vitro, comprising an enzyme having D-lactate oxidising activity, and a means for detecting a reaction product of said enzyme.

Abstract: Intelligent voice response systems and methods may include one or more machine readable instructions stored in a memory that cause a processor to receive an automated input including at least two of the following: a vehicle metric of the vehicle, a driving score of a user of the vehicle, a driving time during a trip of the vehicle, a geographical location of the vehicle, an adverse weather event within a predetermined distance of the vehicle, a historical driving route of the vehicle, a predicted driving route of the vehicle within a first predetermined period of time, or a sound within a predetermined distance of the vehicle. An action may be generated and implemented and reception of an affirmative response from the user may be determined. An alert may be generated to the user based on the affirmative response.

Abstract: A computing system helps a user in an extended reality (XR) learning experience achieve mastery through personalized, programmable and conversational coaching. One aspect is that the XR learning experience may consist of a plurality of tasks associated with the user. A second aspect is that the XR learning experience can define different types of conversational interventions triggered by the computing system at various times. A third aspect is that some tasks or interventions can make use of a conversational assistant. A fourth aspect is that as the user is going through the XR learning experience, the system determines which, if any, interventions can be triggered based on the user's state.

Abstract: Intelligent voice response systems and methods may include one or more machine readable instructions stored in a memory that cause a processor to receive an automated input including at least two of the following: a vehicle metric of the vehicle, a driving score of a user of the vehicle, a driving time during a trip of the vehicle, a geographical location of the vehicle, an adverse weather event within a predetermined distance of the vehicle, a historical driving route of the vehicle, a predicted driving route of the vehicle within a first predetermined period of time, or a sound within a predetermined distance of the vehicle. An action may be generated and implemented and reception of an affirmative response from the user may be determined. An alert may be generated to the user based on the affirmative response.

Abstract: This invention relates to a crystalline 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I), and compositions thereof. Also disclosed herein are methods of making the same and methods of using the same.

Abstract: This invention relates to a crystalline 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I), and compositions thereof. Also disclosed herein are methods of making the same and methods of using the same.

Abstract: This invention relates to a 19-nor C3,3-disubstituted C21-pyrazolyl steroid of formula (I) and pharmaceutical compositions thereof. Also disclosed herein are methods of making the pharmaceutical compositions of the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of formula (I) and methods of using the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of formula (I) or crystalline solid forms, pharmaceutically acceptable salts, and pharmaceutically acceptable compositions thereof.

Abstract: A computing system generates an extended reality environment for an end user. The extended reality environment includes a plurality of tasks and a plurality of goals to be achieved by the end user. The computing system receives input data from an extended reality system associated with the end user. The computing system updates a progress of the end user through the plurality of tasks and the plurality of goals based on the input data. The computing system receives a voice command from the end user. The voice command corresponds to a statement uttered by the end user within the extended reality environment. The computing system processes the voice command to generate a response to the voice command. The computing system causes the response to appear within the extended reality environment as an audible, visual or haptic feedback response to the voice command.

Abstract: Provided herein are pharmaceutically acceptable aqueous solution comprising a neuroactive steroid, a sulfobutyl ether beta cyclodextrin and a buffer; wherein: the solution is a stable solution between a pH of about 3 and about 9, e.g., at room temperature, for at least 1, 2, 3, 4 weeks; 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 months; 1, 2, 3 years or more; the buffer is present at a concentration of at least 0.1 mM; or the solution remains substantially free of impurities (e.g., the solution is substantially free of impurities at room temperature for at least 1, 2, 3, 4 weeks; 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 months; 1, 2, 3 years or more).

Abstract: This invention relates to a 19-nor C3,3-disubstituted C21-pyrazolyl steroid of formula (I) and pharmaceutical compositions thereof. Also disclosed herein are methods of making the pharmaceutical compositions of the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of formula (I) and methods of using the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of formula (I) or crystalline solid forms, pharmaceutically acceptable salts, and pharmaceutically acceptable compositions thereof.

Abstract: A method comprises receiving an area of interest (AOI) selection. The method further comprises accessing an AOI device location data for the AOI, the AOI device location data indicating locations of devices over time received within the AOI. The AOI device location data is filtered to only include the device location data that match one or more characteristics. A proximity zone is determined for the for the AOI that includes the area of the AOI. A zone device location data for the proximity zone is determined, which indicates locations of devices over time reported within the proximity zone. The method further comprises normalizing the filtered AOI device location data by computing a ratio of the filtered AOI device location data and the zone device location data to generate an AOI user estimate, and transmitting the AOI user estimate to a client device of a requestor.

Abstract: A computing system helps a user in an extended reality (XR) learning experience achieve mastery through personalized, programmable and conversational coaching. One aspect is that the XR learning experience may consist of a plurality of tasks associated with the user. A second aspect is that the XR learning experience can define different types of conversational interventions triggered by the computing system at various times. A third aspect is that some tasks or interventions can make use of a conversational assistant. A fourth aspect is that as the user is going through the XR learning experience, the system determines which, if any, interventions can be triggered based on the user's state.

Abstract: A computing system generates an extended reality environment for an end user. The extended reality environment includes a plurality of tasks and a plurality of goals to be achieved by the end user. The computing system receives input data from an extended reality system associated with the end user. The computing system updates a progress of the end user through the plurality of tasks and the plurality of goals based on the input data. The computing system receives a voice command from the end user. The voice command corresponds to a statement uttered by the end user within the extended reality environment. The computing system processes the voice command to generate a response to the voice command. The computing system causes the response to appear within the extended reality environment as an audible, visual or haptic feedback response to the voice command.

Abstract: This invention relates to a crystalline 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I), and compositions thereof. Also disclosed herein are methods of making the same and methods of using the same.

Abstract: This invention relates to a 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) and crystalline solid forms and compositions thereof. Also disclosed herein are methods of making crystalline solid forms of the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) and methods of using the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) or crystalline solid forms, pharmaceutically acceptable salts, and pharmaceutically acceptable compositions thereof.

Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence and kits and devices for use in said methods. The methods employ restriction enzymes, polymerase and oligonucleotide primers to produce an amplification product in the presence of a target nucleic acid, which is contacted with oligonucleotide probes to produce a detector product.

Abstract: A method comprises receiving an area of interest (AOI) selection. The method further comprises accessing an AOI device location data for the AOI, the AOI device location data indicating locations of devices over time received within the AOI. The AOI device location data is filtered to only include the device location data that match one or more characteristics. A proximity zone is determined for the for the AOI that includes the area of the AOI. A zone device location data for the proximity zone is determined, which indicates locations of devices over time reported within the proximity zone. The method further comprises normalizing the filtered AOI device location data by computing a ratio of the filtered AOI device location data and the zone device location data to generate an AOI user estimate, and transmitting the AOI user estimate to a client device of a requestor.