Patents by Inventor Steven William Homans

Steven William Homans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of screening compounds for biological activity
    Publication number: 20030077628
    Abstract: The present invention provides a method of screening compounds to identify ligands that bind to specific target molecules using nuclear magnetic resonance (NMR) and the measurement of residual dipolar couplings. The method is particularly useful in screening and/or identifying compounds which bind to specific target molecules, for example proteins, polypeptides and macromolecules so as to assist in rational drug design.
    Type: Application
    Filed: October 15, 2002
    Publication date: April 24, 2003
    Inventors: Steven William Homans, Hiroki Shimizu
  • 13C, 15N, 2H labeled proteins for NMR structure determinations and their preparation
    Patent number: 6376253
    Abstract: The invention is concerned with determining the three-dimensional structure of biological macromolecules such as proteins. In particular, it is concerned with methods for rapidly determining protein structure by NMR, by providing methods for simplifying NMR spectra using labeled proteins prepared from specifically isotopically labeled amino acids having at least two isotopes of 13C, 15N and 2H in the backbone, and methods for making these labeled proteins, e.g., by cultivation of a microbial culture containing said labeled amino acids.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: April 23, 2002
    Assignee: Martek Biosciences Corporation
    Inventors: Frank Elbert Anderson, III, Jonathan Miles Brown, Philip Edward Coughlin, Steven William Homans, Charles Tobias Weller, Carrie Ann Zimmerman-Wilson, Eddie James Oliver, Jr.
  • 13C, 15N, 2H labeled proteins for NMR structure determinations and their preparation
    Patent number: 6340578
    Abstract: This invention is concerned with determining the three-dimensional structure of biological macromolecules such as proteins. In particular, it is concerned with methods for rapidly determining protein structure by NMR, by providing methods for simplifying NMR spectra using labeled proteins prepared from specifically isotopically labeled amino acids having at least two isotopes of 13C, 15N and 2H in the backbone, and methods for making these labeled proteins, e.g., by cultivation of a microbial culture containing said labeled amino acids.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: January 22, 2002
    Assignee: Martek Biosciences Corporation
    Inventors: Frank Elbert Anderson, III, Jonathan Miles Brown, Philip Edward Coughlin, Steven William Homans, Charles Tobias Weller, Carrie Ann Zimmerman-Wilson, Eddie James Oliver, Jr.
  • 13C,15N ,2H labeled proteins for NMR structure determinations and their preparation
    Patent number: 6335196
    Abstract: This invention is concerned with determining the three-dimensional structure of biological macromolecules such as proteins. In particular, it is concerned with methods for rapidly determining protein structure by NMR, by providing methods for simplifying NMR spectra using labeled proteins prepared from specifically isotopically labeled amino acids having at least two isotopes of 13C, 15N and 2H in the backbone, and methods for making these labeled proteins, e.g., by cultivation of a microbial culture containing said labeled amino acids.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: January 1, 2002
    Assignee: Martek Biosciences Corp.
    Inventors: Frank Elbert Anderson, III, Jonathan Miles Brown, Philip Edward Coughlin, Steven William Homans, Charles Tobias Weller, Carrie Ann Zimmerman-Wilson, Eddie James Oliver, Jr.
  • Peptidic molecules which have been isotopically substituted with .sup.13 C, .sup.15 N and .sup.2 H in the backbone but not in the sidechains
    Patent number: 6111066
    Abstract: Peptidic molecules suitable for three dimensional NMR structure determination are provided which have been substituted with .sup.13 C and/or .sup.15 N in the backbone and/or at the .alpha.-carbon with .sup.2 H but not otherwise in the sidechains of the amino acid residues. One or more amino acids, amino acid species or substantially all of the amino acid residues of the molecule may be so substituted. A method of making the substituted peptidic molecules substituted in this manner is provided.
    Type: Grant
    Filed: September 2, 1997
    Date of Patent: August 29, 2000
    Assignee: Martek Biosciences Corporation
    Inventors: Frank Elbert Anderson, III, Jonathan Miles Brown, Philip Edward Coughlin, Steven William Homans, Charles Tobias Weller, Carrie Ann Zimmerman-Wilson