Abstract: The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

Abstract: Various examples of a closed-loop optical gyroscope are disclosed. The closed-loop optical gyroscope includes a broadband light source configured to generate broadband optical signal(s). The broadband optical signal(s) propagate in an optical resonator and are coupled in and out of the optical resonator by optical couplers. A phase modulator applies phase modulation to the optical signal(s) based on a sawtooth modulation signal. The optical signal(s) repropagate in the optical resonator in a different direction. The optical signal(s) are then received and analyzed to determine parameter(s) of the phase modulator. One or more processors configure the phase modulator based on the determined parameter(s).

Abstract: A mechanical hand mimics a human hand having similar degrees of freedom and sensory abilities while appearing visually similar to human hand. The mechanical hand comprises a mechanical hand skeleton and resilient elastomer (e.g., silicone) skin that fully encloses the mechanical hand skeleton. The mechanical hand skeleton may advantageously be molded directly into the resilient elastomer (e.g., silicone) skin such that the hand appears, moves, and feels very similar to a real human hand. The mechanical hand may have applications in robotics, for example as an end-of-arm tool or end effector, or may have other applications. Robotic applications may include prosthetics applications.

Abstract: Implementations selectively message member account data to client applications to reduce server load. When a monitored load on cloud servers meets a criteria, a hold status may be triggered. During the hold status, member accounts may be monitored and client applications may be transmitted push messages, for example when a change is detected in a member's monitored account. The push messages can contain the detected changes, such as a posted transaction that triggered the message. Implementations of the client application can be configured to display local data (stored from the push messages) during the hold status in response to a member's request to access/view their account. Because server to client communication is limited to messages that contain member account changes, an overall server load can be reduced.

Abstract: A catheter comprising an elongated catheter body, an electrode array distal of the catheter body, the array having a mounting member and at least first and second spine supports. Each spine support includes a base having a planar configuration, and a plurality of spines extending from the base, wherein the first base extends in a first plane and the second base extends in a second plane different from the first plane in the mounting member.

Abstract: Methods and systems for monitoring use, determining risk, and pricing insurance policies for a vehicle having autonomous or semi-autonomous operation features are provided. According to certain aspects, a computer-implemented method for generating or updating usage-based insurance policies for an autonomous or semi-autonomous vehicle may be provided. A request to generate an insurance quote may be received via wireless communication, and with the customer's permission, risk levels associated with intended usage by the customer of the vehicle may be determined. An insurance policy may be adjusted based upon the risk levels and the intended vehicle usage. The insurance policy may then be presented on the customer's mobile device for review and approval. In some aspects, the vehicle may be rented, and the intended vehicle usage is measured in distance or duration of vehicle operation. Insurance discounts may be provided to risk averse vehicle owners based upon low risk levels.

Abstract: Provided herein are acyclic oxazepinyl compounds useful in the treatment on cancers.

Abstract: A catheter comprising an elongated catheter body, and an electrode assembly distal of the catheter body, the assembly comprising a plurality of spines, wherein each spine has a distal end that is connected to the distal end of at least one other spine, wherein each spine has an electrode-carrying portion, the electrode-carrying portions of all spines of the assembly being in a single common plane, and wherein all spines of the assembly have a uniform exposed total length.

Abstract: A gyroscope comprises a source emitting a broadband beam, and a first waveguide arrangement that splits the beam into CCW and CW beams. First and second phase modulators are coupled to the waveguide arrangement and provide phase modulations or frequency shifts to the CCW and CW beams. An optical resonator is in communication with the phase modulators such that the CCW and CW beams are optically coupled into the resonator. A second waveguide arrangement receives the CCW and CW beams transmitted from the resonator. First and second RIN detectors are coupled to the second waveguide arrangement and respectively receive the CCW and CW beams. A rate detector receives the CCW and CW beams. A rate calculation unit receives intensity noise signals from the RIN detectors, and rate and intensity noise signals from the rate detector. The rate calculation unit performs a RIN subtraction technique to reduce intensity noise limited ARW.

Abstract: A photonics device comprises a waveguide platform including a substrate layer, a cladding layer over the substrate layer, and a waveguide layer embedded in the cladding layer. The waveguide layer includes a waveguide ring resonator, and a bus waveguide in optical communication with the waveguide ring resonator. The waveguide ring resonator is configured to generate a stimulated Brillouin scattering (SBS) beam when a pump laser beam is optically coupled into the waveguide ring resonator from the bus waveguide. The waveguide ring resonator has a radius and corresponding round-trip path length such that a free-spectral range (FSR) of the waveguide ring resonator is misaligned with respect to a SBS gain peak of the SBS beam, such that an SBS gain coefficient has a magnitude to produce a substantially reduced linewidth of the SBS beam.

Abstract: Techniques are provided for implementing and using a travelling wave resonator. comprising planar optical waveguide including at least two stacked cores, to diminish Kerr effect in the travelling wave resonator. The travelling wave resonator may be used in a resonator optical gyroscope.

Abstract: An infusion pump for detection of a fluid condition in a flexible tubing is provided. The infusion pump includes a sensor positioned to obtain a value of a tubing force when the tube is received by the infusion pump, a memory storing instructions and a processor. The processor is configured to execute the instructions to generate a force-time curve representative of values of the tubing force obtained by the sensor over time, determine a time-decaying parameter associated with the tubing force characterizing the force-time curve, and determine a fluid pressure value for a fluid in the tube based at least in part on the time-decaying parameter, a material of the tube, a dimension of the tube, and a use history of the tube. A method for using an infusion pump is also provided.

Abstract: Platform assembly for use with sorting articles comprises platforms connected to each other to form at least one level surface for transit thereabout by a plurality of vehicles. Each platform defines a first orientation in which the platform is in a retracted position and a second orientation in which the platform is in an extended position with a horizontal disposition. Each platform includes a first panel comprising a plurality of markers thereon, the markers forming a grid on the first panel for transit thereabout by the plurality of vehicles. Each marker includes a magnetic signature for determining an orientation of the marker. A container is positioned about at least one of the plurality of markers. In operation, the vehicle is directed by a control system to deposit an article carried thereon into a container associated with a marker based on the location and orientation of the marker.

Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.

Abstract: Methods and systems for monitoring use, determining risk, and pricing insurance policies for a vehicle having one or more autonomous or semi-autonomous operation features are provided. According to certain aspects, the operating status of the features, the identity of a vehicle operator, risk levels for operation of the vehicle by the vehicle operator, or damage to the vehicle may be determined based upon sensor or other data. According to further aspects, decisions regarding transferring control between the features and the vehicle operator may be made based upon sensor data and information regarding the vehicle operator. Additional aspects may recommend or install updates to the autonomous operation features based upon determined risk levels. Some aspects may include monitoring transportation infrastructure and communicating information about the infrastructure to vehicles.

Abstract: A surface cleaning head with dual rotating agitators (e.g., a leading roller and a brush roll) may be used to facilitate capturing of debris in the air flow into a suction conduit on the underside of the surface cleaning head. The leading roller is generally positioned adjacent to and in advance of the opening of the suction conduit. The rotating brush roll may be located in the suction conduit with the leading roller located in front of and spaced from the brush roll, forming an inter-roller air passageway therebetween. The leading roller may provide a softer cleaning element than the brush roll and may also have an outside diameter that is less than the outside diameter of the brush roll. The surface cleaning head may also include debriding protrusions contacting the leading roller and/or a leading bumper that extends in front of the leading roller.

Abstract: A photonics gyroscope comprises a light source on a photonics chip that emits a broadband beam; a waveguide resonator; a reflective component; first and second detectors, the second detector coupled to the source; a RIN servo loop coupled between the second detector and the source; and a rate calculation unit. The beam is directed into the resonator such that it propagates in a CCW direction. A portion of the CCW beam is coupled out of the resonator toward the reflective component and reflected back as a reflected beam that is coupled into the resonator such that the reflected beam propagates in a CW direction. The CW beam is coupled out of the resonator to the first detector, which detects a resonance frequency shift between the CW and CCW beams. The RIN servo loop stabilizes an intensity of the beam such that bias error and noise is reduced.

Abstract: The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifen, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

Abstract: Techniques are provided for implementing and using a travelling wave resonator, comprising planar optical waveguide including at least two stacked cores, to diminish Kerr effect in the travelling wave resonator. The travelling wave resonator may be used in a resonator optical gyroscope.

Abstract: A catheter comprising an elongated catheter body, an electrode array distal of the catheter body, the array having a mounting member and at least first and second spine supports. Each spine support includes a base having a planar configuration, and a plurality of spines extending from the base, wherein the first base extends in a first plane and the second base extends in a second plane different from the first plane in the mounting member.