Abstract: Provided herein are acyclic oxazepinyl compounds useful in the treatment on cancers.

Abstract: A catheter comprising an elongated catheter body, and an electrode assembly distal of the catheter body, the assembly comprising a plurality of spines, wherein each spine has a distal end that is connected to the distal end of at least one other spine, wherein each spine has an electrode-carrying portion, the electrode-carrying portions of all spines of the assembly being in a single common plane, and wherein all spines of the assembly have a uniform exposed total length.

Abstract: A gyroscope comprises a source emitting a broadband beam, and a first waveguide arrangement that splits the beam into CCW and CW beams. First and second phase modulators are coupled to the waveguide arrangement and provide phase modulations or frequency shifts to the CCW and CW beams. An optical resonator is in communication with the phase modulators such that the CCW and CW beams are optically coupled into the resonator. A second waveguide arrangement receives the CCW and CW beams transmitted from the resonator. First and second RIN detectors are coupled to the second waveguide arrangement and respectively receive the CCW and CW beams. A rate detector receives the CCW and CW beams. A rate calculation unit receives intensity noise signals from the RIN detectors, and rate and intensity noise signals from the rate detector. The rate calculation unit performs a RIN subtraction technique to reduce intensity noise limited ARW.

Abstract: A photonics device comprises a waveguide platform including a substrate layer, a cladding layer over the substrate layer, and a waveguide layer embedded in the cladding layer. The waveguide layer includes a waveguide ring resonator, and a bus waveguide in optical communication with the waveguide ring resonator. The waveguide ring resonator is configured to generate a stimulated Brillouin scattering (SBS) beam when a pump laser beam is optically coupled into the waveguide ring resonator from the bus waveguide. The waveguide ring resonator has a radius and corresponding round-trip path length such that a free-spectral range (FSR) of the waveguide ring resonator is misaligned with respect to a SBS gain peak of the SBS beam, such that an SBS gain coefficient has a magnitude to produce a substantially reduced linewidth of the SBS beam.

Abstract: Techniques are provided for implementing and using a travelling wave resonator. comprising planar optical waveguide including at least two stacked cores, to diminish Kerr effect in the travelling wave resonator. The travelling wave resonator may be used in a resonator optical gyroscope.

Abstract: An infusion pump for detection of a fluid condition in a flexible tubing is provided. The infusion pump includes a sensor positioned to obtain a value of a tubing force when the tube is received by the infusion pump, a memory storing instructions and a processor. The processor is configured to execute the instructions to generate a force-time curve representative of values of the tubing force obtained by the sensor over time, determine a time-decaying parameter associated with the tubing force characterizing the force-time curve, and determine a fluid pressure value for a fluid in the tube based at least in part on the time-decaying parameter, a material of the tube, a dimension of the tube, and a use history of the tube. A method for using an infusion pump is also provided.

Abstract: Platform assembly for use with sorting articles comprises platforms connected to each other to form at least one level surface for transit thereabout by a plurality of vehicles. Each platform defines a first orientation in which the platform is in a retracted position and a second orientation in which the platform is in an extended position with a horizontal disposition. Each platform includes a first panel comprising a plurality of markers thereon, the markers forming a grid on the first panel for transit thereabout by the plurality of vehicles. Each marker includes a magnetic signature for determining an orientation of the marker. A container is positioned about at least one of the plurality of markers. In operation, the vehicle is directed by a control system to deposit an article carried thereon into a container associated with a marker based on the location and orientation of the marker.

Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.

Abstract: Methods and systems for monitoring use, determining risk, and pricing insurance policies for a vehicle having one or more autonomous or semi-autonomous operation features are provided. According to certain aspects, the operating status of the features, the identity of a vehicle operator, risk levels for operation of the vehicle by the vehicle operator, or damage to the vehicle may be determined based upon sensor or other data. According to further aspects, decisions regarding transferring control between the features and the vehicle operator may be made based upon sensor data and information regarding the vehicle operator. Additional aspects may recommend or install updates to the autonomous operation features based upon determined risk levels. Some aspects may include monitoring transportation infrastructure and communicating information about the infrastructure to vehicles.

Abstract: A surface cleaning head with dual rotating agitators (e.g., a leading roller and a brush roll) may be used to facilitate capturing of debris in the air flow into a suction conduit on the underside of the surface cleaning head. The leading roller is generally positioned adjacent to and in advance of the opening of the suction conduit. The rotating brush roll may be located in the suction conduit with the leading roller located in front of and spaced from the brush roll, forming an inter-roller air passageway therebetween. The leading roller may provide a softer cleaning element than the brush roll and may also have an outside diameter that is less than the outside diameter of the brush roll. The surface cleaning head may also include debriding protrusions contacting the leading roller and/or a leading bumper that extends in front of the leading roller.

Abstract: A photonics gyroscope comprises a light source on a photonics chip that emits a broadband beam; a waveguide resonator; a reflective component; first and second detectors, the second detector coupled to the source; a RIN servo loop coupled between the second detector and the source; and a rate calculation unit. The beam is directed into the resonator such that it propagates in a CCW direction. A portion of the CCW beam is coupled out of the resonator toward the reflective component and reflected back as a reflected beam that is coupled into the resonator such that the reflected beam propagates in a CW direction. The CW beam is coupled out of the resonator to the first detector, which detects a resonance frequency shift between the CW and CCW beams. The RIN servo loop stabilizes an intensity of the beam such that bias error and noise is reduced.

Abstract: The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifen, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

Abstract: Techniques are provided for implementing and using a travelling wave resonator, comprising planar optical waveguide including at least two stacked cores, to diminish Kerr effect in the travelling wave resonator. The travelling wave resonator may be used in a resonator optical gyroscope.

Abstract: A catheter comprising an elongated catheter body, an electrode array distal of the catheter body, the array having a mounting member and at least first and second spine supports. Each spine support includes a base having a planar configuration, and a plurality of spines extending from the base, wherein the first base extends in a first plane and the second base extends in a second plane different from the first plane in the mounting member.

Abstract: In some examples, systems and methods for object tracking are provided. For example, a method includes: receiving an image frame in a sequence of image frames; identifying an object of interest in the image frame using a single-object tracker (SOT) based upon one or more templates associated with the object of interest in a template repository; generating a SOT output based on the identified object of interest; and detecting one or more objects in the image frame using a multiple-object tracker (MOT). In some examples, the MOT including a machine-learning model. In some examples, the method further includes conducting a matching between the SOT output and each detected object of the one or more detected objects to generate a match result; and generating a tracker output based at least in part on the SOT output, the one or more detected objects, and the match result.

Abstract: Aspects of the present disclosure are directed to techniques to simulate conditions while progressing towards a goal state using token conversions. Tokens can be assets associated with a defined goal and can be implemented to segment accounts for a defined purpose and to improve user planning. An account can be segmented by converting a portion of the user's account balance to tokens to progress towards the goal. In some implementations, a simulation can generate a target token conversion schedule that achieves a target number of tokens at a target date. However, user behavior can change the observed token amounts and cause deviations from the schedule. The simulations can alter the token conversion schedule and arrive at a new target date for the target number of tokens. In some implementations, automated agents and machine learning components can be used to implement the token tracking and simulations.

Abstract: Provided herein are, inter alia, methods and composition for the treatment of cancers that are recalcitrant to treatment and/or become resistant to certain drug treatments. The methods provided may, inter alia, be used to treat cancer in subjects having elevated STAT1 activity levels.

Abstract: A photonics gyroscope comprises a laser and a common intensity modulation unit that outputs an intensity modulated beam, split into a CCW beam having a first power level and a CW beam having a second power level. A first phase modulator (PA) receives the CCW beam, and a second PA receives the CW beam. A variable optical attenuator (VOA) is coupled to the first or second PA. The CCW beam is coupled into a resonator and the CW beam is coupled into the resonator. A first detector receives the CCW beam and a second detector receives the CW beam from the resonator. A CCW control loop locks the CCW beam, and a CW control loop locks the CW beam, to resonance peaks. The VOA receives a feedback loop signal to aid in balancing power levels between CCW and CW beams to eliminate a rate signal at an intensity modulation frequency.

Abstract: In some examples, systems and methods for user-assisted object detection are provided. For example, a method includes: receiving a first image frame of a sequence of image frames, performing object detection using an object tracker to identify an object of interest in the first image frame, based upon one or more templates associated with the object of interest in a template repository, outputting a first indicator associated with a first image portion corresponding to the identified object of interest, and receiving a user input associated with the object of interest. In some examples, the user input indicates an identified image portion in the image frame. In some examples, the method further includes generating a retargeted template, based at least in part on the identified image portion, and determining a second image portion associated with the object of interest in a second image frame of the sequence of image frames using the object tracker, based at least in part on the retargeted template.

Abstract: Methods and systems for monitoring use, determining risk, and pricing insurance policies for a vehicle having autonomous or semi-autonomous operation features are provided. According to certain aspects, a computer-implemented method for generating or updating usage-based insurance policies for autonomous or semi-autonomous vehicles may be provided. A request to generate an insurance quote may be received via wireless communication, and with the customer's permission, risk levels associated with intended usage by the customer of an autonomous or semi-autonomous vehicle may be determined. An insurance policy may be adjusted based upon the risk levels and the intended vehicle usage. The insurance policy may then be presented on the customer's mobile device for review and approval. In some aspects, the vehicle may be rented, and the intended vehicle usage is measured in distance or duration of vehicle operation. Insurance discounts may be provided to risk averse vehicle owners based upon low risk levels.