Abstract: This disclosure relates to methods treating cancer comprising administering to a subject in need thereof a lipid nanoparticle comprising a therapeutically effective amount of a CRISPR/Cas system comprising one or more nucleic acid sequences encoding one or more guide RNAs (gRNAs) that are complementary to one or more target sequences in a cancer gene of a cancer cell and a nucleic acid sequence encoding a CRISPR-associated endonuclease.

Abstract: This disclosure relates to methods treating a solid tumor by intratumorally administering a CRISPR/Cas system comprising one or more nucleic acid sequences encoding one or more guide RNAs that are complementary to one or more target sequences in a cancer gene of a cancer cell of the solid tumor and a nucleic acid sequence encoding a CRISPR-associated endonuclease.

Abstract: A system for a mobile gift card marketplaces is disclosed. The system may initiate a contactless payment at a merchant via a mobile app. The system may receive an authorization message based on the contactless payment. The system may execute an authorization process in response to receiving the authorization message to determine an authorized transaction. The system may validate the authorized transaction to determine whether the authorized transaction is associated with a customer. The system may execute a merchant validation process to determine if the authorized transaction is associated with a merchant. The system may determine an available gift card account balance of the customer associated with the merchant in response to determining the authorized transaction is associated with both the customer and the merchant. The system may execute a gift card redemption process to redeem the available gift card account balance of the customer associated with the merchant.

Abstract: A system for a mobile gift card marketplaces is disclosed. The system may initiate a contactless payment at a merchant via a mobile app. The system may receive an authorization message based on the contactless payment. The system may execute an authorization process in response to receiving the authorization message to determine an authorized transaction. The system may validate the authorized transaction to determine whether the authorized transaction is associated with a customer. The system may execute a merchant validation process to determine if the authorized transaction is associated with a merchant. The system may determine an available gift card account balance of the customer associated with the merchant in response to determining the authorized transaction is associated with both the customer and the merchant. The system may execute a gift card redemption process to redeem the available gift card account balance of the customer associated with the merchant.

Abstract: The disclosure provides recombinant adenoviruses comprising a polynucleotide comprising: a first DNA sequence encoding a guide RNA (gRNA), wherein the gRNA comprises a DNA-binding domain and a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease protein-binding domain, and the DNA-binding domain is complementary to a target sequence in a gene; and a first promoter that is operably linked to the DNA sequence. The disclosure also provides pharmaceutical compositions comprising the adenoviruses described herein. The disclosure further provides a method of treating cancer in a subject, the method comprising administering to the subject a therapeutically effective amount of the pharmaceutical compositions as described herein to the subject.

Abstract: Systems and methods for intelligent and adaptive testing of a blockchain application to identify compliant code modifications. The method includes the steps of recording requests to and response from a baseline blockchain application receiving the requests from a plurality of application users. The same responses are input into a shadow blockchain application that includes a number of switch selectable new code segments. The switch selectable new code is enabled and disabled according to a pattern. The responses from the baseline application are compared against the response from the shadow blockchain application from when error vectors are generated. These error vectors are used to train a learning machine to determine which new code segments result in response errors or aberrations.

Abstract: A system for a mobile gift card marketplaces is disclosed. The system may initiate a contactless payment at a merchant via a mobile app. The system may receive an authorization message based on the contactless payment. The system may execute an authorization process in response to receiving the authorization message to determine an authorized transaction. The system may validate the authorized transaction to determine whether the authorized transaction is associated with a customer. The system may execute a merchant validation process to determine if the authorized transaction is associated with a merchant. The system may determine an available gift card account balance of the customer associated with the merchant in response to determining the authorized transaction is associated with both the customer and the merchant. The system may execute a gift card redemption process to redeem the available gift card account balance of the customer associated with the merchant.

Abstract: Systems and methods for efficiently serving blockchain requests using an optimized cache are disclosed herein. An example method normalizing a request for blockchain data into a key, the request including a hash of a canonical head block of the blockchain data, searching a distributed key value store using the key, the distributed key value store comprising key value pairs, each of the key value pairs being associated with responsive blockchain data, determining when one of the key value pairs match the key, placing a pending job space for a job in the distributed key value store when one of the key value pairs is not found, and storing a new key value pair in the distributed key value store when a response for the request is obtained, the response being new responsive blockchain data.

Abstract: A flash drive protection structure includes a decoration cover and a protective cover. The decoration cover that is made by elastic materials includes a cover block and a receiving space spacedly. The cover block has a cover hole facing the receiving space, and a connecting post is formed inside the receiving space. The protective cover has a first and a second surface, and the protective cover is disposed in the receiving space of the decoration cover through the first surface, while the second surface is exposed outside the decoration cover. The protective cover has a connecting hole at the first surface to connect the connecting post of the decoration cover. Also, the protective cover has a receiving trough toward the cover block, and one end of the flash drive is plugged into the receiving trough, while the other end is plugged into the cover hole of the cover block.

Abstract: A flash drive protection structure includes a decoration cover and a protective cover. The decoration cover that is made by elastic materials includes a cover block and a receiving space spacedly. The cover block has a cover hole facing the receiving space, and a connecting post is formed inside the receiving space. The protective cover has a first and a second surface, and the protective cover is disposed in the receiving space of the decoration cover through the first surface, while the second surface is exposed outside the decoration cover. The protective cover has a connecting hole at the first surface to connect the connecting post of the decoration cover. Also, the protective cover has a receiving trough toward the cover block, and one end of the flash drive is plugged into the receiving trough, while the other end is plugged into the cover hole of the cover block.

Abstract: An antenna structure includes a first tubing module, a second tubing module, an insulating tubing, a coaxial cable, an insulating tube and a base. Both ends of the insulating tubing are connected with the first and second tubing modules respectively. An interval is maintained between two corresponding ends connected with the tubing modules. The first tubing module is connected to the insulating tube, and the insulating tube is connected the base. The coaxial cable includes a central conductor and a metal conducting mesh, and the central conductor is connected the second tubing module, and the second tubing module is connected to a terminal inside the base. The metal conducting mesh is connected to the first tubing module, and the first tubing module is connected the base, so that the antenna structure can be operated at a specific frequency range and gives a better gain.

Abstract: An attenuator includes a main body and a circuit board module, wherein the main body is made of an electrically conducting metal, and an installing portion is concavely disposed between both ends of the main body, and a portion of the circuit board module is disposed on the installing portion for reducing the contact area between the circuit board module and the main body, so as to lower the parasite capacitance of the attenuator between the circuit board module and the main body, and the circuit board module processes a signal introduced by the main body according to a predetermined attenuation.

Abstract: The present invention is to provide a connector, which includes a casing; a first signal transmitting unit having a portion protruded from the casing and another portion extended into the casing; a second signal transmitting unit disposed in the casing and electrically coupled to the first signal transmitting unit; a third signal transmitting unit movably installed in the casing and having a portion insulatedly coupled to the second signal transmitting unit. If a portion of the third signal transmitting unit is pushed, the second signal transmitting unit will electrically disconnect the first signal transmitting unit, and another portion of the third signal transmitting unit will electrically connect the second signal transmitting unit.

Abstract: A learning aid which can be implemented in computer software where a user's responses to a timed worksheet are used to adjust parameters used in selecting the problems and time limit in a successively timed worksheet. Parameters can include problem complexity, the mode or type of problems having a given complexity, the number of problems, worksheet time limit, and measures of user performance including time remaining and the number of correct, incorrect and non-completed answers to problems. Performance is tracked over successive worksheets in order to arrive at a user's competency level and to provide the user feedback tailored to enhance the learning experience.

Abstract: Conventional fabrication of sidewall oxide around an ONO-type memory cell stack usually produces Bird's Beak because prior to the fabrication, there is an exposed sidewall of the ONO-type memory cell stack that exposes side parts of a plurality of material layers respectively composed of different materials. Certain materials in the stack such as silicon nitrides are more difficult to oxidize than other materials in the stack such polysilicon. As a result oxidation does not proceed uniformly along the multi-layered height of the sidewall. The present disclosure shows how radical-based fabrication of sidewall dielectric can help to reduce the Bird's Beak formation. More specifically, it is indicated that short-lived oxidizing agents (e.g.

Abstract: An implantable device for selectively controlling defecation has an outer body defining on one end a flange that is surgically attachable to the person's anus and/or tissue adjacent to the anus. A connector is mounted on the other end of the outer body and is secured to the distal end of the person's large intestine for connecting the large intestine in fluid communication with the device. An inner body is slidably received within the outer body. A macerator-type pump is mounted within the inner body and an inlet valve is mounted between the pump and the connector. An actuator in the form of an RF receiver is electrically coupled to the inlet valve and the pump and a remote transmitter is operatively coupled to the receiver. The receiver is responsive to control signals received from the transmitter to open the inlet valve and operate the pump in order to move fecal matter through the device.

Abstract: The number of computations performed in rendering graphics is reduced by computing certain terms only at the beginning of each scanline. A scanline gradient is calculated once at the beginning of each scanline for each of two texture values with respect to the x-coordinate of the scanline. Following the scanline gradient calculations at the beginning of each scanline, a pixel gradient is calculated for each pixel of the scanline with respect to the y-coordinate of the scanline. The sum of the squares of the scanline gradients and the pixel gradients are compared, and the larger of the two quantities is selected to be a maximum Rho constant term for the corresponding pixel, wherein the maximum Rho constant is used to select a texture map for rendering the corresponding pixel. Furthermore, at the beginning of each scanline, a pixel gradient may be calculated for each of two texture values for a first pixel of the scanline with respect to the y-coordinate of the scanline.

Abstract: Methods and apparatus for mapping texture, which may encode three-dimensional elements, from a first raster of pixels (e.g., a texture map) to a second raster of pixels (e.g., a displayable frame buffer or other target map). The pixels of the first raster include a recession component q and the pixels of the second raster include a recession component w. Successive pixels of the target map are mapped to corresponding pixels of the texture map, linearly interpolated to account for recession, and assigned values consistent with the interpolation. Unlike prior systems, which are designed to scan pixels along horizontal rows or vertical columns, the invention scans along lines where the quantity q/w is constant. These scan lines are generally parallel to one another, obviating the need for repeated slope computations; they also tend to correspond to similar levels of detail in prefiltered (e.g., mip map) texture representations, obviating the need for shifting among representations.