Patents by Inventor Stewart A. Frankel

Stewart A. Frankel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solubilization of protein after bacterial expression using sarkosyl
    Patent number: 5240834
    Abstract: This invention relates to two methods for solubilizing proteins which are rendered insoluble by bacterial expression. One method comprises directly lysing the host bacterial cells with the detergent Sarkosyl. The other method comprises conventional lysing of the bacteria followed by an extraction process using Sarkosyl and fractionation. These methods render the proteins soluble. They do not entail harsh denaturation of the proteins, and therefore do not require renaturation of the proteins in many cases. Rather, they render the proteins soluble, in their native form.
    Type: Grant
    Filed: January 22, 1991
    Date of Patent: August 31, 1993
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Stewart A. Frankel, Leslie A. Leinwand