Abstract: Estimation and imaging of linear and nonlinear propagation and scattering parameters in a material object where the material parameters for wave propagation and scattering has a nonlinear dependence on the wave field amplitude. The methods transmit at least two pulse complexes composed of co-propagating high frequency (HF) and low frequency (LF) pulses along at least one LF and HF transmit beam axis, where said HF pulse propagates close to the crest or trough of the LF pulse along at least one HF transmit beam, and where one of the amplitude and polarity of the LF pulse varies between at least two transmitted pulse complexes. At least one HF receive beam crosses the HF transmit beam at an angle, to provide at least two HF cross-beam receive signals from at least two transmitted pulse complexes with different LF pulses.

Abstract: Methods and instrumentation for pulse scattering estimation and imaging of scattering parameters in a material object by transmitting a pulse along a transmit beam and directing a receive beam that crosses at least one transmit beam at an angle <45 deg. The receive beam is at least in an azimuth direction at the transmit beam, and records scattered receive signal from the overlap region. A receive interval of the receive signal is gated for further processing to form measurement and/or image signals from cross-beam observation cells.

Abstract: Estimation of vibration amplitude of intra-capillary micro-bubbles driven to vibrate with an incident ultrasound wave with amplitude and frequency to adjust the drive amplitude of the incident wave to obtain specified vibration amplitude of extra-capillary tissue. Estimation uses transmission of M groups of pulse complexes having low frequency pulse (LF) at bubble drive frequency, and high frequency (HF) pulse with angular frequency ?H>˜5?L, and pulse duration shorter than ?/4?L along HF beam. The phase between HF and LF pulses is ?Ltm for each group, where tm varies between the groups. Within each group, LF pulse varies between pulse complexes in amplitude and/or, where the LF pulse can be zero for a pulse complex, and LF pulse is different from zero for pulse complex within each group. HF receive signals are processed to obtain a parameter relating to bubble vibration amplitude when the HF pulse hits bubble.

Abstract: Estimation of vibration amplitude of intra-capillary micro-bubbles driven to vibrate with an incident ultrasound wave with amplitude and frequency to adjust the drive amplitude of the incident wave to obtain specified vibration amplitude of extra-capillary tissue. Estimation uses transmission of M groups of pulse complexes having low frequency pulse (LF) at bubble drive frequency, and high frequency (HF) pulse with angular frequency ?H> ~ 5 ?L, and pulse duration shorter than ?/4?L along HF beam. The phase between HF and LF pulses is ?Ltm for each group, where tm varies between the groups. Within each group, LF pulse varies between pulse complexes in amplitude and/or, where the LF pulse can be zero for a pulse complex, and LF pulse is different from zero for pulse complex within each group. HF receive signals are processed to obtain a parameter relating to bubble vibration amplitude when the HF pulse hits bubble.

Abstract: Increasing the immune response to a given cancer in a patient through increasing lymphatic flow out of the cancer region, following a primary action of the cancer that loads professional antigen-presenting cells/dendritic cells (APCs/DCs) with tumor-associated antigen (TAA) from the tumor into the interstitial fluid of the cancer region. Example primary actions are radio-therapy, both stereotactic and brachytherapy using implanted seeds, proton-therapy, and chemical- or radio-pharmaceutical therapy. Intra-capillary micro-bubbles in the tumor are brought to vibrate with incident ultrasound of appropriate frequency and amplitude, producing vibrations in the extra capillary tissue that produces an outward acoustic radiation force and micro shear waves in the tissue that increases transport of the interstitial fluid.

Abstract: Methods and instrumentation for estimation of nonlinear bulk elasticity parameters (NEP) of a material through measuring nonlinear propagation delays (NPDs) at a set of multiple range cells along at least one transmit beam axis, and adapting said NEPs to minimize a functional of the NEPs. The method calculates a distance between a model of the NPDs with the NEPs as input and the measured NPDs, and estimated NEPs are obtained at the minimum of the functional. The NPDs are measured by transmitting at least two pulse complexes comprising a low frequency (LF) and a high frequency (HF) pulse with differences in the LF pulse, along at least one common LF and HF transmit beam axes, and gating out HF receive signals from a multitude of depth ranges along said at least one HF transmit beam axis, and comparing the HF receive signals from two pulse complexes with difference in the LF pulse for each depth range.

Abstract: Estimation and imaging of linear and nonlinear propagation and scattering parameters in a material object where the material parameters for wave propagation and scattering has a nonlinear dependence on the wave field amplitude. The methods transmit at least two pulse complexes composed of co-propagating high frequency (HF) and low frequency (LF) pulses along at least one LF and HF transmit beam axis, where said HF pulse propagates close to the crest or trough of the LF pulse along at least one HF transmit beam, and where one of the amplitude and polarity of the LF pulse varies between at least two transmitted pulse complexes. At least one HF receive beam crosses the HF transmit beam at an angle, to provide at least two HF cross-beam receive signals from at least two transmitted pulse complexes with different LF pulses.

Abstract: Methods and instrumentation for pulse scattering estimation and imaging of scattering parameters in a material object by transmitting a pulse along a transmit beam and directing a receive beam that crosses at least one transmit beam at an angle <45 deg. The receive beam is at least in an azimuth direction at the transmit beam, and records scattered receive signal from the overlap region. A receive interval of the receive signal is gated for further processing to form measurement and/or image signals from cross-beam observation cells.

Abstract: Methods and instrumentation for estimation of nonlinear bulk elasticity parameters (NEP) of a material through measuring nonlinear propagation delays (NPDs) at a set of multiple range cells along at least one transmit beam axis, and adapting said NEPs to minimize a functional of the NEPs. The method calculates a distance between a model of the NPDs with the NEPs as input and the measured NPDs, and estimated NEPs are obtained at the minimum of the functional. The NPDs are measured by transmitting at least two pulse complexes comprising a low frequency (LF) and a high frequency (HF) pulse with differences in the LF pulse, along at least one common LF and HF transmit beam axes, and gating out HF receive signals from a multitude of depth ranges along said at least one HF transmit beam axis, and comparing the HF receive signals from two pulse complexes with difference in the LF pulse for each depth range.

Abstract: A riser connector assembly includes a first connector assembly portion with first locking members, a second connector assembly portion with second locking members, and a locking device with third and fourth locking members. The locking device is rotatably connected to the first connector assembly portion. The locking device rotates between a first position where each of the locking members are interlocked, a second position where the first and third locking members are interlocked, and the second and fourth locking members are not interlocked, and a third position where none of the locking members are interlocked, so that the locking device is removable. The first and third locking members selectively/releasably interlock via a relative rotation between the first connector assembly portion and the locking device. The second and fourth locking members selectively/releasably interlock via a relative rotation between the second connector assembly portion and the locking device.

Abstract: A riser connector assembly includes a first connector assembly portion comprising first locking members, a second connector assembly portion comprising second locking members, and a locking device comprising third and fourth locking members. The locking device is rotatably connected to the first connector assembly portion. The locking device is configured to rotate between a first position where each of the locking members are interlocked, a second position where the first and third locking members are interlocked, and the second and fourth locking members are not interlocked, and a third position where none of the locking members are interlocked, so that the locking device is removable. The first and third locking members selectively/releasably interlock via a relative rotation between the first connector assembly portion and the locking device. The second and fourth locking members selectively/releasably interlock via a relative rotation between the second connector assembly portion and the locking device.