Abstract: An implantable glucose sensor includes: a housing, two injecting electrodes for injecting current into the tissue, two sensing electrodes for measuring impedance in the tissue, a coil within the housing for powering the sensor via a power source, a circuit board within the housing, the circuit board being electrically connected to the two sensing electrodes and the two injecting electrodes and the coil, and a communication unit for communicating data. The communication unit is connected to the circuit board. The two sensing electrodes and the two injecting electrodes are arranged on an outer surface of a first part of the housing. The outer surface of first part is of a convex shape. The two sensing electrodes and the two injecting electrodes are embedded in the convex shape so that they are flush with the outer surface of the convex shape.

Abstract: The present invention relates to an implantable sensor configured to be implanted within the body of the subject and being configured to measure impedance within a body tissue of the subject resulting from an electrical current flowing through the body tissue, wherein the body tissue is sub-dermal or subcutaneous tissue of the subject. One pair of injection electrodes is configured for injection of electrical current into the body tissue and one pair of sensing electrodes is configured to detect the resulting voltage. A detector is operatively connected to the sensing electrodes and is configured to receive the voltage detected by the sensing electrodes, wherein the detector is configured to measure the impedance of the body tissue based on the voltage detected by the pair of sensing electrodes.

Abstract: The present invention relates to a health monitoring system comprising an implantable sensor configured to measure impedance within a body tissue of the subject resulting from an electrical current flowing through said body tissue, wherein the body tissue is sub-dermal or subcutaneous tissue of said subject, the sensor including a powering and communication circuit having a coil configured to be powered by an electromagnetic field and to communicate with external devices.

Abstract: A method and an apparatus for measuring glucose level in the body fluid of a subject, typically blood glucose level, by measuring impedance of a body tissue, with two pairs of electrodes, two electrodes for injecting current into a body tissue and two electrodes for detecting the ensuing voltage of the body tissue. The body tissue is typically a sub-dermal or sub-cutaneous tissue. The measured impedance of the body tissue is used to correlate with directly determined glucose levels to determine the glucose level from the measured impedance. It is thus possible to determine body fluid glucose levels in a reliable and reproducible manner.

Abstract: Medical apparatus for diagnosing of a diseased condition of the skin of a subject. The apparatus comprises an electrically conducting probe including a plurality of electrodes, each electrode comprising a plurality of micro-needles, wherein each electrode comprises a base substrate, said micro-needles being integrally formed with said substrate and arranged in a laterally spaced relationship apart from each other and having a length being sufficient to penetrate the stratum corneum, said micro-needles being arranged with an at least partially oblique shape. Furthermore, the present invention relates to an electrode for use in the device, arrays of micro-needle and method for the diagnostics of biological conditions using impedance measurements. The diagnostics is in particular related to cancer, and preferably skin cancer, wherein skin cancer is a basal cell carcinoma, a malignant melanoma, a squamous cell carcinoma, or precursors of such lesions.

Abstract: A method and an apparatus for measuring glucose level in the body fluid of a subject, typically blood glucose level, by measuring impedance of a body tissue, with two pairs of electrodes, two electrodes for injecting current into a body tissue and two electrodes for detecting the ensuing voltage of the body tissue. The body tissue is typically a sub-dermal or sub-cutaneous tissue. The measured impedance of the body tissue is used to correlate with directly determined glucose levels to determine the glucose level from the measured impedance. It is thus possible to determine body fluid glucose levels in a reliable and reproducible manner.

Abstract: The present invention relates to a health monitoring system comprising an implantable sensor configured to measure impedance within a body tissue of the subject resulting from an electrical current flowing through said body tissue, wherein the body tissue is sub-dermal or subcutaneous tissue of said subject, the sensor including a powering and communication circuit having a coil configured to be powered by an electromagnetic field and to communicate with external devices.

Abstract: The present invention relates to an implantable sensor configured to be implanted within the body of the subject and being configured to measure impedance within a body tissue of the subject resulting from an electrical current flowing through the body tissue, wherein the body tissue is sub-dermal or subcutaneous tissue of the subject. One pair of injection electrodes is configured for injection of electrical current into the body tissue and one pair of sensing electrodes is configured to detect the resulting voltage. A detector is operatively connected to the sensing electrodes and is configured to receive the voltage detected by the sensing electrodes, wherein the detector is configured to measure the impedance of the body tissue based on the voltage detected by the pair of sensing electrodes.

Abstract: A method and an apparatus for measuring glucose level in the body fluid of a subject, typically blood glucose level, by measuring impedance of a body tissue, with two pairs of electrodes, two electrodes for injecting current into a body tissue and two electrodes for detecting the ensuing voltage of the body tissue. The body tissue is typically a sub-dermal or sub-cutaneous tissue. The measured impedance of the body tissue is used to correlate with directly determined glucose levels to determine the glucose level from the measured impedance. It is thus possible to determine body fluid glucose levels in a reliable and reproducible manner.

Abstract: Apparatus and methods for the diagnostics of biological conditions using impedance measurements.

Abstract: The present invention relates generally to the field of measuring glucose levels in a body fluid of a subject, in particular to non-invasive measuring of blood glucose in blood of a subject. A device is disclosed comprising an electrically conducting probe comprising a plurality of electrodes adapted for measuring electrical impedance of the tissue of a subject, typically skin, a sensing device adapted for sensing at least one concentration of an ion in the tissue, typically acidity (pH), wherein said electrically conducting probe and said sensing device are adapted to obtain said electrical impedance of the tissue and said concentration of an ion in the tissue simultaneously. The device further comprises a blood glucose determining unit adapted for determining an estimate, typically a concentration, of blood glucose based on said electrical impedance of the tissue and said concentration of an ion in the tissue.

Abstract: Apparatus and methods for the diagnostics of biological conditions using impedance measurements are provided wherein an electrical conducting probe can be placed against a skin surface of the subject, wherein the probe is made up of a plurality of electrodes in the form of spikes, the spikes being laterally spaced apart from each other and being of sufficient length to penetrate the stratum corneum, passing an electrical current through the electrodes to obtain a value of impedance for the skin, and converting the impedance to a concentration of a substance such as glucose in blood of a subject.

Abstract: A method and an apparatus for measuring glucose level in the body fluid of a subject, typically blood glucose level, by measuring impedance of a body tissue, with two pairs of electrodes, two electrodes for injecting current into a body tissue and two electrodes for detecting the ensuing voltage of the body tissue. The body tissue is typically a sub-dermal or sub-cutaneous tissue. The measured impedance of the body tissue is used to correlate with directly determined glucose levels to determine the glucose level from the measured impedance. It is thus possible to determine body fluid glucose levels in a reliable and reproducible manner.

Abstract: Medical apparatus for diagnosing of a diseased condition of the skin of a subject. The apparatus comprises an electrically conducting probe including a plurality of electrodes, each electrode comprising a plurality of micro-needles, wherein each electrode comprises a base substrate, said micro-needles being integrally formed with said substrate and arranged in a laterally spaced relationship apart from each other and having a length being sufficient to penetrate the stratum corneum, said micro-needles being arranged with an at least partially oblique shape. Furthermore, the present invention relates to an electrode for use in the device, arrays of micro-needle and method for the diagnostics of biological conditions using impedance measurements. The diagnostics is in particular related to cancer, and preferably skin cancer, wherein skin cancer is a basal cell carcinoma, a malignant melanoma, a squamous cell carcinoma, or precursors of such lesions.

Abstract: A non-invasive method of monitoring a biological parameter concerning a bodily fluid of a subject, e.g., blood glucose of a human subject. The method includes: placing an electrode against a site of the skin of the subject; measuring impedance of the skin and determining the parameter therefrom; and using substantially the same site in another determination. Another non-invasive monitoring method includes: exposing a skin site to an aqueous salt solution for a pre-determined first period of time; removing excess of the solution from the site; measuring impedance at the site; exposing the site to the solution for a pre-determined second period of time and repeating the removing and measuring steps. It is determined whether the impedance measured falls within a pre-determined range. The latter exposure and removal steps are repeated, if necessary, until two consecutive impedance measurements within the pre-determined range are obtained.

Abstract: Apparatus and methods for the diagnostics of biological conditions using impedance measurements.

Abstract: A non-invasive method of monitoring a biological parameter concerning a bodily fluid of a subject, e.g., blood glucose of a human subject. The method includes: placing an electrode against a site of the skin of the subject; measuring impedance of the skin and determining the parameter therefrom; and using substantially the same site in another determination. Another non-invasive monitoring method includes: exposing a skin site to an aqueous salt solution for a pre-determined first period of time; removing excess of the solution from the site; measuring impedance at the site; exposing the site to the solution for a pre-determined second period of time and repeating the removing and measuring steps. It is determined whether the impedance measured falls within a pre-determined range. The latter exposure and removal steps are repeated, if necessary, until two consecutive impedance measurements within the pre-determined range are obtained.

Abstract: A method and apparatus is disclosed for non-invasively determining glucose levels in a fluid of a subject, typically the blood glucose level. The impedance of skin tissue is measured and the measurement is used with impedance measurements previously correlated with directly determined glucose levels to determine the glucose level from the newly measured impedance. It is thus possible, to routinely non-invasively determine fluid glucose levels.

Abstract: A device and method for noninvasive depth-selective detection and characterization of surface phenomena in organic and biological material such as tissues by surface measurement of the electrical impedance of the material. The device includes a probe with a plurality of measuring electrodes separated by a control electrode. Measuring equipment measures impedance in a desired frequency range. An adjustable amplifier maintains a chosen control signal derived from the potential of one of the measuring electrodes at the control electrode without loading the measuring electrode. Depth selectivity is achieved by controlling the extension of the electric field in the vicinity of the measuring electrodes by the control electrode actively driven with the same frequency as the measuring electrodes.