Patents by Inventor Stjepan Kukolja

Stjepan Kukolja has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-Dithio-3-imido-azetidin-2-ones
    Patent number: 4024152
    Abstract: A novel 4-(2'-benzothiazolyldithio)-3-imidoazetidin-2-one of the formula ##STR1## in which X is chloro or bromo and R.sub.2 is methylene or oxygen is ring-closed to the corresponding 3-exomethylenecepham or 3-"oxo" cepham by treatment with sodium or potassium iodide at a temperature of from about 40.degree. C. to about 80.degree. C.
    Type: Grant
    Filed: September 19, 1975
    Date of Patent: May 17, 1977
    Assignee: Eli Lilly and Company
    Inventor: Stjepan Kukolja
  • Azetidinone acetic acid intermediates for 5-epi-penicillins
    Patent number: 3962276
    Abstract: 5-Epi-penicillin esters and acids, the acids being useful as inhibitors of .beta.-lactamase type enzymes, a process for preparing such compounds by reacting an ester of a 2-halo-.alpha.-(1'-halothio-1'-methylethyl)-4-oxo-3-imido-1-azetidineaceta te with (a) zinc in acid or (b) stannous chloride in an organic liquid medium at 0.degree. to 100.degree.C., and some new 2-halo-.alpha.-(1'-cyanodithia- or 1'-mercapto-1'-methylethyl)-4-oxo-3-imido-2-azetidineacetate which are useful as intermediates in preparing the 5-epi-penicillins.
    Type: Grant
    Filed: November 14, 1974
    Date of Patent: June 8, 1976
    Assignee: Eli Lilly and Company
    Inventor: Stjepan Kukolja
  • Preparation of 6-acylamino-2-methyl-2-halomethyl penams
    Patent number: 3960844
    Abstract: A 7-acylamino-3-hydroxy-3-methylcepham-4-carboxylic acid ester is reacted with a mixture of a halogenating agent and a tertiary carboxamide to produce a 2-halomethylpenam compound, a useful intermediate for the preparation of desacetoxycephalosporins.
    Type: Grant
    Filed: February 11, 1975
    Date of Patent: June 1, 1976
    Assignee: Eli Lilly and Company
    Inventors: Stjepan Kukolja, Steven R. Lammert