Patents by Inventor Stjepan P. Kukolja

Stjepan P. Kukolja has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for cleaving an imido side chain from penicillins and cephalosporins
    Patent number: 4005074
    Abstract: The amic acid group of a 7-(amic acid) cephalosporin or 6-(amic acid) penicillin is cleaved by dehydration to the corresponding novel 7-isoimidocephalosporin or 6-isoimido-penicillin, and cleavage of the 7-isoimidocephalosporin or 6-isoimidopenicillin to the corresponding 7-aminocephalosporin or 6-aminopenicillin or to a corresponding 7-acylamidocephalosporin or 6-acylamidopenicillin.
    Type: Grant
    Filed: June 18, 1973
    Date of Patent: January 25, 1977
    Assignee: Eli Lilly and Company
    Inventors: Stjepan P. Kukolja, Steven R. Lammert
  • Cephalosporin cleavage process
    Patent number: 4001239
    Abstract: A 7-(amic acid) cephalosporin is cleaved by conversion to the corresponding mixed anhydride and cleavage of the mixed anhydride to the corresponding 7-aminocephalosporin or to a corresponding 7-acylamidocephalosporin.
    Type: Grant
    Filed: June 13, 1975
    Date of Patent: January 4, 1977
    Assignee: Eli Lilly and Company
    Inventors: Stjepan P. Kukolja, Steven R. Lammert
  • Cephalosporin cleavage process
    Patent number: 3994888
    Abstract: A 7-(amic acid) cephalosporin is cleaved by conversion to the corresponding mixed anhydride and cleavage of the mixed anhydride to the corresponding 7-aminocephalosporin or to a corresponding 7-acylamidocephalosporin.
    Type: Grant
    Filed: June 13, 1975
    Date of Patent: November 30, 1976
    Assignee: Eli Lilly and Company
    Inventors: Stjepan P. Kukolja, Steven R. Lammert
  • Process for preparing a desacetoxycephalosporin from a penam and/or a cepham compound
    Patent number: 3968108
    Abstract: A 3.alpha.-methyl-3.beta.-halocepham compound and/or a 2.alpha.-methyl-2.beta.-halomethylpenam compound is converted to a mixture comprising a 3-methyl-3-cephem (desacetoxycephalosporin), a 3.alpha.-methyl-3.beta.-acyloxycepham, and a 2.alpha.-methyl-2.beta.-acyloxymethylpenam by reaction of said 3-halocepham compound and/or said 2-halomethylpenam compound with a silver salt of a lower alkyl carboxylic acid or a cycloalkyl carboxylic acid.
    Type: Grant
    Filed: March 27, 1974
    Date of Patent: July 6, 1976
    Assignee: Eli Lilly and Company
    Inventors: Stjepan P. Kukolja, Steven R. Lammert
  • 3-Nitrooxycepham compounds and process for preparing desacetoxycephalosporins therefrom
    Patent number: 3962226
    Abstract: A 3.alpha.-methyl-3.beta.-halocepham compound and/or a 2.alpha.-methyl-2.beta.-halomethylpenam compound is converted to a mixture comprising a 3-methyl-3-cephem (desacetoxycephalosporin), a 3.alpha. -methyl-3.beta.-nitrooxycepham, and a 2.alpha.-methyl-2.beta.-nitrooxymethylpenam by reaction of said halocepham compound and/or said halomethylpenam compound with silver nitrate. The novel 3-nitrooxycepham compound upon heating is converted to a desacetoxycephalosporin.
    Type: Grant
    Filed: March 27, 1974
    Date of Patent: June 8, 1976
    Assignee: Eli Lilly and Company
    Inventors: Stjepan P. Kukolja, Steven R. Lammert
  • Process for the conversion of 3-methyl-3-hydroxycepham compounds
    Patent number: 3932387
    Abstract: A 7-imido-3-methyl-3-hydroxycepham-4-carboxylic acid ester is reacted with a halogen reagent in the presence of an alkaline reagent to produce 2-halomethylpenams and a 3-methyl-3-cephem compound.
    Type: Grant
    Filed: March 27, 1974
    Date of Patent: January 13, 1976
    Assignee: Eli Lilly and Company
    Inventors: Stjepan P. Kukolja, Steven R. Lammert