Patents by Inventor Struan Grant

Struan Grant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL DRUGGABLE TARGETS FOR THE TREATMENT OF INFLAMMATORY DISEASES SUCH AS SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND METHODS FOR DIAGNOSIS AND TREATMENT USING THE SAME
    Publication number: 20230054595
    Abstract: Compositions and methods for the management and treatment of inflammatory disorders including SLE are disclosed.
    Type: Application
    Filed: December 18, 2020
    Publication date: February 23, 2023
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Struan Grant, Andrew Wells, Chun Su
  • Genetic alterations and methods of use thereof for the diagnosis and treatment of type I diabetes
    Patent number: 10125395
    Abstract: Compositions and methods for the diagnosis and treatment of T1D are disclosed. More specifically, the invention provides gene targets containing single nucleotide polymorphisms associated with this disease. Methods and kits for using the sequences so identified for diagnostic and therapeutic purposes are also provided.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: November 13, 2018
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Jonathan Bradfield, Struan Grant, Hakon Hakonarson
  • GENETIC ALTERATIONS ASSOCIATED WITH AUTISM AND THE AUTISTIC PHENOTYPE AND METHODS OF USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OF AUTISM
    Publication number: 20180148786
    Abstract: Compositions and methods for the detection and treatment of autism and autistic spectrum disorder are provided.
    Type: Application
    Filed: October 9, 2017
    Publication date: May 31, 2018
    Inventors: Hakon Hakonarson, Joseph Glessner, Jonathan Bradfield, Struan Grant, Haitao Zhang, Kai Wang
  • Genetic alterations associated with autism and the autistic phenotype and methods of use thereof for the diagnosis and treatment of autism
    Patent number: 9783851
    Abstract: Compositions and methods for the detection and treatment of autism and autistic spectrum disorder are provided.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: October 10, 2017
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Hakon Hakonarson, Joseph Glessner, Jonathan Bradfield, Struan Grant, Haitao Zhang, Kai Wang
  • Genetic Alterations Associated with Type I Diabetes and Methods of Use Thereof for Diagnosis and Treatment
    Publication number: 20150023984
    Abstract: Compositions and methods for the detection and treatment of T1D are provided.
    Type: Application
    Filed: April 14, 2014
    Publication date: January 22, 2015
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Hakon Hakonarson, Jonathan Bradfield, Struan Grant, Constantin Polychronakos
  • Genetic Alterations and Methods of Use Thereof for the Diagnosis and Treatment of Type 1 Diabetes
    Publication number: 20140255387
    Abstract: Compositions and methods for the diagnosis and treatment of T1D are disclosed. More specifically, the invention provides gene targets containing single nucleotide polymorphisms associated with this disease. Methods and kits for using the sequences so identified for diagnostic and therapeutic purposes are also provided.
    Type: Application
    Filed: October 18, 2012
    Publication date: September 11, 2014
    Inventors: Jonathan Bradfield, Struan Grant, Hakon Hakonarson
  • Markers for Obesity and Methods of Use Thereof
    Publication number: 20130035240
    Abstract: Markers for obesity, particularly childhood obesity, are provided along with methods of use thereof.
    Type: Application
    Filed: February 22, 2011
    Publication date: February 7, 2013
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Struan Grant, Joseph Glessner, Hakon Hakonarson
  • Genetic Alterations on Chromosomes 21q, 6q and 15q and Methods of Use Thereof for the Diagnosis and Treatment of Type I Diabetes
    Publication number: 20110236370
    Abstract: Compositions and methods for the detection and treatment of T1D are provided.
    Type: Application
    Filed: November 16, 2010
    Publication date: September 29, 2011
    Inventors: Hakon Hakonarson, Struan Grant, Jonathan Bradfield, Constantin Polychronakos, Hui-Qi Qu
  • Genetic Alterations Associated with Autism and the Autistic Phenotype and Methods of Use Thereof for the Diagnosis and Treatment of Autism
    Publication number: 20110207124
    Abstract: Compositions and methods for the detection and treatment of autism and autistic spectrum disorder are provided.
    Type: Application
    Filed: February 20, 2009
    Publication date: August 25, 2011
    Inventors: Hakon Hakonarson, Joseph Glessner, Jonathan Bradfield, Struan Grant, Haitao Zhang, Kai Wang
  • IDENTIFICATION OF PEDIATRIC ONSET INFLAMMATORY DISEASE LOCI AND METHODS OF USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OF THE SAME
    Publication number: 20110177502
    Abstract: Compositions and methods for detection and treatment of inflammatory bowel disease are provided.
    Type: Application
    Filed: February 19, 2009
    Publication date: July 21, 2011
    Inventors: Hakon Hakonarson, Jonathan Bradfield, Marcin Imielinski, Struan Grant
  • Genetic variants in the TCF7L2 gene as diagnostic markers for risk of type 2 diabetes mellitus
    Publication number: 20060286588
    Abstract: Polymorphisms in the gene TCF7L2 are shown by association analysis to be a susceptibility gene for type II diabetes. Methods of diagnosis of susceptibility to diabetes, of decreased susceptibility to diabetes and protection against diabetes, are described, as are methods of treatment for type II diabetes.
    Type: Application
    Filed: June 16, 2006
    Publication date: December 21, 2006
    Inventor: Struan Grant
  • Human type II diabetes gene-slit-3 located on chromosome 5q35
    Publication number: 20060141462
    Abstract: Association of Type II diabetes and a locus on chromosome 5q35 is disclosed. In particular, the gene SLIT-3 with this locus is shown by linkage analysis to be a susceptibility gene for Type II diabetes. Pathway targeting for drug delivery and diagnosis applications in identifying those have Type II diabetes or at risk of developing Type II diabetes, in particular those that are non-obese are described.
    Type: Application
    Filed: October 31, 2003
    Publication date: June 29, 2006
    Inventors: Inga Reynisdottir, Jeffrey Gulcher, Struan Grant, Gudmar Thorleifsson
  • Human type II diabetes gene - Kv channel-interacting protein (KChIP1) located on chromosome 5
    Publication number: 20050214780
    Abstract: Association of Type II diabetes and a locus on chromosome 5 is disclosed. In particular, the gene KChIP1 within this locus is shown by linkage analysis to be a susceptibility gene for Type II diabetes. Pathway targeting for drug delivery and diagnosis applications in identifying those who have Type II diabetes or are at risk of developing Type II diabetes, in particular those that are non-obese are described.
    Type: Application
    Filed: April 7, 2004
    Publication date: September 29, 2005
    Applicant: deCODE genetics ehf.
    Inventors: Inga Reynisdottir, Jeffrey Gulcher, Struan Grant, Gudmar Thorleifsson
  • Human Type II diabetes gene - Kv channel-interacting protein (KChIP1) located on chromosome 5
    Publication number: 20050196784
    Abstract: Association of Type II diabetes and a locus on chromosome 5 is disclosed. In particular, the gene KChIP1 within this locus is shown by linkage analysis to be a susceptibility gene for Type II diabetes. Pathway targeting for drug delivery and diagnosis applications in identifying those who have Type II diabetes or are at risk of developing Type II diabetes, in particular those that are non-obese are described.
    Type: Application
    Filed: January 5, 2005
    Publication date: September 8, 2005
    Applicant: deCODE genetics ehf.
    Inventors: Inga Reynisdottir, Jeffrey Gulcher, Struan Grant, Gudmar Thorleifsson
  • Identical-by-descent fragment enrichment
    Patent number: 6524794
    Abstract: Methods of identifying DNA fragments comprising DNA that is identical by descent for two individuals are disclosed.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: February 25, 2003
    Assignee: deCode genetics ehf.
    Inventors: Struan Grant, Thorarinn Blöndal
  • Detection of C4A deletion by long range PCR
    Patent number: 6225093
    Abstract: Methods are described for detecting a deletion in the C4A gene (e.g., for detecting C4AQ0), by performing long range polymerase chain reaction amplification on a test sample comprising genomic DNA. The methods amplify target DNA comprising a retroviral insert in intron 9 of the C4A gene using primers designed such that PCR products are formed only if the test sample comprises genomic DNA comprising a deletion in the C4A gene; alternatively, the methods amplify target DNA comprising the junction between intron 9 and the retroviral insert in intron 9 of the C4A gene using primers designed such that PCR products are formed only if the test sample comprises genomic DNA that does not comprise the deletion in the C4A gene. Alternatively, primers are designed such that PCR products have detectably different sizes, depending on whether or the test sample comprises genomic DNA that comprises the deletion in the C4A gene.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: May 1, 2001
    Assignee: deCODE genetics ehf.
    Inventors: Struan Grant, Thorarinn Blöndal