Abstract: The present disclosure relates to the diagnosis, treatment and prophylaxis of age-related diseases, and increasing healthspan. Provided are methods of treating or preventing an age-related disease/condition, and in particular of treating or preventing frailty, comprising administering a therapeutically or prophylactically effective amount of an agent capable of inhibiting interleukin 11 (IL-11)-mediated signalling to a subject. Also provided are agents capable of inhibiting interleukin 11 (IL-11)-mediated signalling for use in such a method. Further provided is the use of agents capable of inhibiting interleukin 11 (IL-11)-mediated signalling in the manufacture of a medicament for use in such a method.

Abstract: Epoxidized natural rubber compositions, elastomer blends containing an epoxidized natural rubber, and materials containing carbon black and epoxidized natural rubber.

Abstract: The present invention provides methods and agents for modulating WARS2 expression, WARS2 activity, or a combination thereof, thereby modulating angiogenesis. Also provided herein are methods for identifying individuals who could benefit from agents that modulate WARS2 expression, WARS2 activity, or a combination thereof.

Abstract: Rubber compounds comprising one or more rubber with polar functionality and one or more polar filler are prepared by a method comprising the steps: (i) adding a polar volatile liquid to the polar filler; (ii) mixing the one or more rubber with polar functionality with the polar volatile liquid and polar filler to produce a dispersion of the polar filler in the one or more rubber; and (iii) removing the polar volatile liquid from the dispersion. The invention Improves the consistency and uniformity of mixing of rubber compounds based on elastomers having polar functionality, such as epoxidized natural rubber, containing polar reinforcing fillers, such as precipitated silica, The compounds, when vulcanized, have improved mechanical properties. The method is particularly useful in the manufacture of vehicle tires.

Abstract: The present invention provides methods and agents for modulating WARS2 expression, WARS2 activity, or a combination thereof, thereby modulating angiogenesis. Also provided herein are methods for identifying individuals who could benefit from agents that modulate WARS2 expression, WARS2 activity, or a combination thereof.

Abstract: Rubber compounds comprising one or more rubber with polar functionality and one or more polar filler are prepared by a method comprising the steps: (i) adding a polar volatile liquid to the polar filler; (ii) mixing the one or more rubber with polar functionality with the polar volatile liquid and polar filler to produce a dispersion of the polar filler in the one or more rubber, and (iii) removing the polar volatile liquid from the dispersion. The invention Improves the consistency and uniformity of mixing of rubber compounds based on elastomers having polar functionality, such as epoxidized natural rubber, containing polar reinforcing fillers, such as precipitated silica, The compounds, when vulcanized, have improved mechanical properties. The method is particularly useful in the manufacture of vehicle tyres.

Abstract: A method and system of conditioning human skin and hair using a hand-held skin/hair conditioner having interchangeable interface conductors that are contoured to enhance electrical conductivity between the conditioner and a variety of body areas. Each of the interchangeable interface conductors are preferably formed to maximize surface area contact with a variety of body surfaces such as scalp/hair, body skin, and facial skin. In a preferred embodiment, the skin/hair conditioner is formed to fit comfortably and controllably in a user's grasp while providing maximum contact with the selected body surface. The skin/hair conditioner includes an audio signal generator and a vibration mechanism to alert a user of a change in status of the conditioner. The interface conductors may be (1) smoothly rounded, (2) include teeth, (3) spherical or hemispherical (4) include multiple rounded nodules.

Abstract: A method and system of conditioning human skin and hair using a hand-held skin/hair conditioner having interchangeable interface conductors that are contoured to enhance electrical conductivity between the conditioner and a variety of body areas. Each of the interchangeable interface conductors are preferably formed to maximize surface area contact with a variety of body surfaces such as scalp/hair, body skin, and facial skin. In a preferred embodiment, the skin/hair conditioner is formed to fit comfortably and controllably in a user's grasp while providing maximum contact with the selected body surface. The skin/hair conditioner includes an audio signal generator and a vibration mechanism to alert a user of a change in status of the conditioner. The interface conductors may be (1) smoothly rounded, (2) include teeth, (3) spherical or hemispherical (4) include multiple rounded nodules.

Abstract: A method and system of conditioning human skin and hair using a hand-held skin/hair conditioner having interchangeable interface conductors that are contoured to enhance electrical conductivity between the conditioner and a variety of body areas. Each of the interchangeable interface conductors are preferably formed to maximize surface area contact with a variety of body surfaces such as scalp/hair, body skin, and facial skin. In a preferred embodiment, the skin/hair conditioner is formed to fit comfortably and controllably in a user's grasp while providing maximum contact with the selected body surface. The skin/hair conditioner includes an audio signal generator and a vibration mechanism to alert a user of a change in status of the conditioner. The interface conductors may be (1) smoothly rounded, (2) include teeth, (3) spherical or hemispherical (4) include multiple rounded nodules.

Abstract: Pigment compositions for oil-based lithographic printing ink systems are provided which comprise as colourant besides an organic pigment an organic dyestuff soluble in an organic solvent (solvent dye). The printing inks prepared from these pigment compositions show outstanding improvements in colour strength combined with improvements in both gloss and transparency of the prints obtained.

Abstract: A thermoplastic elastomer composition comprises a blend of a thermoplastic component with a cured elastomer component characterised in that the elastomer component prior to curing comprises a major proportion of a main elastomer and a minor proportion of a high molecular weight reactive polymer which shows a higher crosslinking efficiency in free-radical induced vulcanisation than the main elastomer. Preferably, the high molecular weight reactive polymer comprises from (3) to (15), and more preferably (4) to (10), parts by weight per one hundred parts of the total elastomer component of the composition. The use of the high molecular weight reactive polymer in the composition improves the low temperature performance of the composition and gives improvements to the processing behaviour, the resistance to stiffening at low temperatures and recovery/relaxation properties. Preferably, the high molecular weight reactive polymer is miscible with the main elastomer in the elastomer component.

Abstract: A method and system of conditioning human skin and hair using a hand-held skin/hair conditioner having interchangeable interface conductors that are contoured to enhance electrical conductivity between the conditioner and a variety of body areas. Each of the interchangeable interface conductors are preferably formed to maximize surface area contact with a variety of body surfaces such as scalp/hair, body skin, and facial skin. In a preferred embodiment, the skin/hair conditioner is formed to fit comfortably and controllably in a user's grasp while providing maximum contact with the selected body surface. The skin/hair conditioner includes an audio signal generator and a vibration mechanism to alert a user of a change in status of the conditioner. The interface conductors may be (1) smoothly rounded, (2) include teeth, (3) spherical or hemispherical (4) include multiple rounded nodules.

Abstract: A method and system of conditioning human skin and hair using a hand-held skin/hair conditioner having interchangeable interface conductors that are contoured to enhance electrical conductivity between the conditioner and a variety of body areas. Each of the interchangeable interface conductors are preferably formed to maximize surface area contact with a variety of body surfaces such as scalp/hair, body skin, and facial skin. In a preferred embodiment, the skin/hair conditioner is formed to fit comfortably and controllably in a user's grasp while providing maximum contact with the selected body surface. The skin/hair conditioner includes an audio signal generator and a vibration mechanism to alert a user of a change in status of the conditioner. The interface conductors may be (1) smoothly rounded, (2) include teeth, (3) spherical or hemispherical (4) include multiple rounded nodules.

Abstract: A method of manufacturing particles, especially nanoparticles, by way of precipitation from solution on a rotating surface (1) of a rotating surface reactor is disclosed. Nanoparticles with a tight size distribution may be manufactured in bulk and without the problems of agglomeration that are associated with traditional stirred-tank reactors. Use of a rotating surface reactor allows precipitation of nanoparticles from viscous, supersaturated solutions by way of homogeneous nucleation aided by strong micromixing.

Abstract: Pigment composition comprising an organic pigment and a combination of at least two normally water-soluble coloured compounds (dyes) of opposing charge, i.e. of at least one anionic and one cationic dye are provided. The compositions impart improved rheology on non-aqueous pigment based printing inks and paints.

Abstract: A thermoplastic elastomer composition comprises a blend of a thermoplastic component with a cured elastomer component characterised in that the elastomer component prior to curing comprises a major proportion of a main elastomer and a minor proportion of a high molecular weight reactive polymer which shows a higher crosslinking efficiency in free-radical induced vulcanisation than the main elastomer. Preferably, the high molecular weight reactive polymer comprises from (3) to (15), and more preferably (4) to (10), parts by weight per one hundred parts of the total elastomer component of the composition. The use of the high molecular weight reactive polymer in the composition improves the low temperature performance of the composition and gives improvements to the processing behaviour, the resistance to stiffening at low temperatures and recovery/relaxation properties. Preferably, the high molecular weight reactive polymer is miscible with the main elastomer in the elastomer component.

Abstract: A method of manufacturing particles, especially nanoparticles, by way of precipitation from solution on a rotating surface (1) of a rotating surface reactor is disclosed. Nanoparticles with a tight size distribution may be manufactured in bulk and without the problems of agglomeration that are associated with traditional stirred-tank reactors. Use of a rotating surface reactor allows precipitation of nanoparticles from viscous, supersaturated solutions by way of homogeneous nucleation aided by strong micromixing.

Abstract: A method and system of conditioning human skin and hair using a hand-held skin/hair conditioner having interchangeable interface conductors that are contoured to enhance electrical conductivity between the conditioner and a variety of body areas. Each of the interchangeable interface conductors are preferably formed to maximize surface area contact with a variety of body surfaces such as scalp/hair, body skin, and facial skin. In a preferred embodiment, the skin/hair conditioner is formed to fit comfortably and controllably in a user's grasp while providing maximum contact with the selected body surface. The skin/hair conditioner includes an audio signal generator and a vibration mechanism to alert a user of a change in status of the conditioner. The interface conductors may be (1) smoothly rounded, (2) include teeth, (3) spherical or hemispherical (4) include multiple rounded nodules.

Abstract: A method and system of conditioning human skin and hair using a hand-held skin/hair conditioner having interchangeable interface conductors that are contoured to enhance electrical conductivity between the conditioner and a variety of body areas. Each of the interchangeable interface conductors are preferably formed to maximize surface area contact with a variety of body surfaces such as scalp/hair, body skin, and facial skin. In a preferred embodiment, the skin/hair conditioner is formed to fit comfortably and controllably in a user's grasp while providing maximum contact with the selected body surface. The skin/hair conditioner includes an audio signal generator and a vibration mechanism to alert a user of a change in status of the conditioner.