Patents by Inventor Stuart A. Jacobson
Stuart A. Jacobson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11939566Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.Type: GrantFiled: September 2, 2021Date of Patent: March 26, 2024Assignee: DEKA Products Limited PartnershipInventors: Christopher C. Langenfeld, David D. B. Cannan, Dirk A. van der Merwe, Dean Kamen, Jason A. Demers, Frederick Morgan, Timothy D. Moreau, Brian D. Tracey, Matthew Ware, Richard J. Lanigan, Michael A. Baker, David Blumberg, Jr., Richard E. Gautney, Derek G. Kane, Dane Fawkes, Thomas J. Bollenbach, Michael C. Tilley, Stuart A. Jacobson, John F. Mannisto
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Publication number: 20230284613Abstract: A system and method for tissue perfusion to assess, maintain, mature, and possibly rehabilitate the tissue. The system of the present teachings includes a tissue enclosure having a fluid reservoir. Pumps, valves, and a controller move perfusate through the tissue. The system includes features to assist in monitoring the health of the tissue, and a removable tray to facilitate moving the tissue from a point of origin to the tissue enclosure. The system moves perfusate to and through the tissue, and provides nutrition to the tissue. The system includes an output flow rate/volume sensor, at least one infusion pump, disposable and durable parts, and a sensor suite.Type: ApplicationFiled: March 16, 2023Publication date: September 14, 2023Inventors: Joshua FILGATE, Scott A. COULL, Piper L. CURTIS, Steven L. HENNING, Bradley HOVAN, Timothy D. MOREAU, Alec C. WOODS, Stuart A. JACOBSON
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Publication number: 20230279322Abstract: System and method for exercising cells and/or tissue in a sealed bioreactor. System includes a cartridge having a stretching means and a means to retain cells on a scaffold mounted within the cartridge during seeding. System includes a bioreactor including a sealed enclosure, the sealed enclosure housing the scaffold and the cartridge, the bioreactor enabling uniform seeding of the scaffold with the cells, the seeding occurring within the sealed enclosure to protect from environmental contamination. The bioreactor system provides a means to supply fresh media to the cells and/or tissue, and a means to remove waste products.Type: ApplicationFiled: March 7, 2023Publication date: September 7, 2023Inventors: Zachary T. KOPS, Michael C. TILLEY, Andrew K. CAPULLI, Stuart A. JACOBSON, Keira L. MCGRATH, Jamie L. NESBITT
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Patent number: 11713442Abstract: Manufacturing system and method for creating multiple tissue constructs from cells. System can include a thaw subsystem (if the cells are provided in a frozen state), an expansion subsystem, a concentration subsystem, and a tissue maturation subsystem. Each of these subsystems is modular and can be reconfigured, and the process can be repeated depending on the specific tissue process being implemented. Multiple tissue types can be combined in multiple bioreactors. The activities of multiple bioreactors can be coordinated and controlled in an automated manner by a supervisor controller. The supervisor controller can receive user input at the start of the process, and can manage the process henceforth, alerting the user if user actions are required.Type: GrantFiled: June 17, 2020Date of Patent: August 1, 2023Assignee: DEKA PRODUCTS LIMITED PARTNERSHIPInventors: Richard E. Andrews, Stephanie M. Miskell, Zachary T. Kops, Justin M. Ferrentino, Michael C. Tilley, Andrew K. Capulli, Keira L McGrath, Stuart A. Jacobson
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Publication number: 20230105287Abstract: A system and method to enable treatment through cell therapy. The system can enable cell injection such as, for example, injecting beta cells/islets, cartilage cells, fat cells, and others. The system and method ensure that the delivery rate and delivered volume of the material pumped through a tube and into the injection needle is consistent over the course of the start-operation-stop process from run to run. The system and method can automatically stop delivery and alarm if an occlusion is detected during delivery.Type: ApplicationFiled: October 6, 2022Publication date: April 6, 2023Inventors: Hans E. JOHNSON, Andrew G. REMEC, David D. B. CANNAN, Keith D. VIOLETTE, Matthew A. NORRIS, Timothy D. MOREAU, Travis G. BIBEAU, Margaret B. BRADLEY, Stuart A. JACOBSON, Robert G. GLOEB-MCDONALD, Scott R. BOWDEN, Richard E. ANDREWS, Dominic P. LOPRIORE, Alden S. NAEEM, Trevor M. NARO, David A. SIMM
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Publication number: 20230043364Abstract: A system and method for maintaining the vitality of an organ through negative pressure ventilation and perfusion. The system includes fluidically coupled components: an organ enclosure, a diaphragm enclosure, an actuator/pump, a perfusion system, and a reservoir. The actuator can displace a precise amount of a working fluid that displaces that precise amount of a sterile support fluid. The sterile fluid travels between the diaphragm enclosure and the organ enclosure, thereby ventilating the organ within the organ chamber. The perfusion system circulates a perfusate through the organ.Type: ApplicationFiled: August 8, 2022Publication date: February 9, 2023Inventors: Michael C. TILLEY, Steven L. HENNING, Joshua FILGATE, Stuart A. JACOBSON, Daniel S. KAROL
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Publication number: 20220333056Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.Type: ApplicationFiled: April 8, 2022Publication date: October 20, 2022Inventors: Christopher C. Langenfeld, David D. B. Cannan, Dirk A. van der Merwe, Dean Kamen, Jason A. Demers, Frederick Morgan, Timothy D. Moreau, Brian D. Tracey, Matthew Ware, Richard J. Lanigan, Michael A. Baker, David Blumberg, JR., Richard E. Andrews, Derek G. Kane, Dane Fawkes, Thomas J. Bollenbach, Michael C. Tilley, Stuart A. Jacobson, John F. Mannisto
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Publication number: 20220228097Abstract: A configurable system for repeatably performing processes related to tissue growth in a controlled environment, possibly part of an industrial production line. The system can accommodate various sizes and shapes of culture vessels, and can maintain the cells at a desired temperature in the culture vessels, thus enabling a plug and play system that can produce consistent and repeatable results. The system includes gas management, fluid management, and control of multiple processes simultaneously, and can be automatically operably coupled with a variety of supporting technologies that can enable tissue-related processes. The system can communicate with supporting technologies upstream and downstream on a manufacturing line, enabling fully automated process control, centralized data historization, and centralized control.Type: ApplicationFiled: January 20, 2022Publication date: July 21, 2022Inventors: Matthew WHITE, Stephanie M. MISKELL, Justin M. FERRENTINO, Richard E. ANDREWS, Stuart A. JACOBSON, Zachary KOPS
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Patent number: 11299705Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.Type: GrantFiled: November 7, 2017Date of Patent: April 12, 2022Assignee: DEKA Products Limited PartnershipInventors: Christopher C. Langenfeld, David D. B. Cannan, Dirk A. van der Merwe, Dean Kamen, Jason A. Demers, Frederick Morgan, Timothy D. Moreau, Brian D. Tracey, Matthew Ware, Richard J. Lanigan, Michael A. Baker, David Blumberg, Jr., Richard E. Gautney, Derek G. Kane, Dane Fawkes, Thomas J. Bollenbach, Michael C. Tilley, Stuart A. Jacobson, John F. Mannisto
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Publication number: 20220041975Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.Type: ApplicationFiled: September 2, 2021Publication date: February 10, 2022Inventors: Christopher C. Langenfeld, David D. B. Cannan, Dirk A. van der Merwe, Dean Kamen, Jason A. Demers, Frederick Morgan, Timothy D. Moreau, Brian D. Tracey, Matthew Ware, Richard J. Lanigan, Michael A. Baker, David Blumberg, JR., Richard E. Gautney, Derek G. Kane, Dane Fawkes, Thomas J. Bollenbach, Michael C. Tilley, Stuart A. Jacobson, John F. Mannisto
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Publication number: 20210395671Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.Type: ApplicationFiled: September 2, 2021Publication date: December 23, 2021Inventors: Christopher C. Langenfeld, David D. B. Cannan, Dirk A. van der Merwe, Dean Kamen, Jason A. Demers, Frederick Morgan, Timothy D. Moreau, Brian D. Tracey, Matthew Ware, Richard J. Lanigan, Michael A. Baker, David Blumberg, JR., Richard E. Gautney, Derek G. Kane, Dane Fawkes, Thomas J. Bollenbach, Michael C. Tilley, Stuart A. Jacobson, John F. Mannisto
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Publication number: 20210395672Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.Type: ApplicationFiled: September 2, 2021Publication date: December 23, 2021Inventors: Christopher C. Langenfeld, David D. B. Cannan, Dirk A. van der Merwe, Dean Kamen, Jason A. Demers, Frederick Morgan, Timothy D. Moreau, Brian D. Tracey, Matthew Ware, Richard J. Lanigan, Michael A. Baker, David Blumberg, JR., Richard E. Gautney, Derek G. Kane, Dane Fawkes, Thomas J. Bollenbach, Michael C. Tilley, Stuart A. Jacobson, John F. Mannisto
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Publication number: 20210259240Abstract: System and method for maintaining an organ and transporting the organ from a donor to a recipient, maintaining normothermic temperature of the organ. The system includes a circulation system providing oxygenated perfusate to the organ and enabling continuous monitoring of the perfusate moving through the organ. The tank can provide an inlet that can accept selected infusible materials, and an outlet that can enable sampling and waste removal. The system can continually monitor the solution bath in which the organ is bathed, and the system can manage the composition of the gas in the tank.Type: ApplicationFiled: February 19, 2021Publication date: August 26, 2021Inventors: Joshua Filgate, Timothy D. Moreau, Scott A. Coull, Piper L. Curtis, Justin M. Ferrentino, Steve L. Henning, Bradley Hovan, Stuart A. Jacobson, Katie E. Leon, Katelyn Mosle
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Publication number: 20200392450Abstract: Manufacturing system and method for creating multiple tissue constructs from cells. System can include a thaw subsystem (if the cells are provided in a frozen state), an expansion subsystem, a concentration subsystem, and a tissue maturation subsystem. Each of these subsystems is modular and can be reconfigured, and the process can be repeated depending on the specific tissue process being implemented. Multiple tissue types can be combined in multiple bioreactors. The activities of multiple bioreactors can be coordinated and controlled in an automated manner by a supervisor controller. The supervisor controller can receive user input at the start of the process, and can manage the process henceforth, alerting the user if user actions are required.Type: ApplicationFiled: June 17, 2020Publication date: December 17, 2020Inventors: Richard E. Andrews, Stephanie M. Miskell, Zachary T. Kops, Justin M. Ferrentino, Michael C. Tilley, Andrew K. Capulli, Keira L McGrath, Stuart A. Jacobson
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Publication number: 20180127705Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.Type: ApplicationFiled: November 7, 2017Publication date: May 10, 2018Inventors: Christopher C. Langenfeld, David D. B. Cannan, Dirk A. van der Merwe, Dean Kamen, Jason A. Demers, Frederick Morgan, Timothy D. Moreau, Brian D. Tracey, Matthew Ware, Richard J. Lanigan, Michael A. Baker, David Blumberg, Richard E. Gautney, Derek G. Kane, Dane Fawkes, Thomas J. Bollenbach, Michael C. Tilley, Stuart A. Jacobson, John F. Mannisto
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Publication number: 20140329223Abstract: The present invention provides photobioreactors, solar energy gathering systems, and methods for thermal control of a culture medium containing a phototrophic organism in a photobioreactor, that allow temperature control in a cost effective manner, reducing the energy required for temperature control of a culture medium containing phototrophic microorganisms in a photobioreactor.Type: ApplicationFiled: April 4, 2014Publication date: November 6, 2014Applicant: JOULE UNLIMITED TECHNOLOGIES, INC.Inventors: Frederick M. Morgan, Stuart A. Jacobson, Johan van Walsem
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Publication number: 20140099706Abstract: The invention relates to a photobioreactor system for a phototrophic microorganism, and culture medium therefor, comprising a reactor chamber and a thermal system.Type: ApplicationFiled: September 13, 2013Publication date: April 10, 2014Applicant: Joule Unlimited Technologies, Inc.Inventors: Michael Y. Leshchiner, Stuart A. Jacobson
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Publication number: 20140099685Abstract: The present invention provides a bioreactor having a reactor chamber and one or more support chambers. The reactor chamber can have one or more flexible walls for enclosing microorganisms and culture medium. The reactor chamber provides an enclosure for microorganism and culture medium. The support chamber can also have one or more flexible walls. When inflated to a predetermined amount, the support chamber causes the microorganisms and culture medium to distribute to a substantially even depth across the reactor chamber.Type: ApplicationFiled: May 24, 2012Publication date: April 10, 2014Inventors: Max B. Tuttman, Stuart A. Jacobson, Rainer Ponzel, John E. Longan
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Patent number: 8678075Abstract: Heat exchanger. The heat exchanger includes a thermal contact plate defining a cavity in fluid communication with a first pipe and a plurality of stationary elements substantially perpendicular to the first pipe each defining a cavity wherein each cavity is in fluid communication with the first pipe and at least one cavity includes a wick. A plurality of movable elements are provided wherein the movable elements and the stationary elements are substantially parallel, alternatingly arranged and a portion of the movable elements overlaps a portion of the stationary elements. A working fluid is provided in the first pipe and cavities or stationary elements and thermal contact plate.Type: GrantFiled: December 1, 2009Date of Patent: March 25, 2014Assignee: Massachusetts Institute of TechnologyInventors: Evelyn N. Wang, John G. Brisson, Stuart A. Jacobson, Jeffrey H. Lang, Matthew McCarthy
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Publication number: 20130244320Abstract: The present invention provides photobioreactors, solar energy gathering systems, and methods for thermal control of a culture medium containing a phototrophic organism in a photobioreactor, that allow temperature control in a cost effective manner, reducing the energy required for temperature control of a culture medium containing phototrophic microorganisms in a photobioreactor.Type: ApplicationFiled: October 12, 2012Publication date: September 19, 2013Applicant: JOULE UNLIMITED TECHNOLOGIES, INC.Inventors: Frederick M. Morgan, Stuart A. Jacobson, Johan van Walsem