Patents by Inventor Stuart A. Kuhstoss

Stuart A. Kuhstoss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Interleukin-1 beta antibodies
    Publication number: 20050075488
    Abstract: The present invention encompasses high affinity antibodies that neutralize IL-1? activity in vivo. These antibodies can be used to treat various diseases such as rheumatoid arthritis and osteoarthritis.
    Type: Application
    Filed: July 18, 2002
    Publication date: April 7, 2005
    Inventors: Stuart Bright, Audrey Jia, Stuart Kuhstoss, Joseph Vincent Manetta, Naoya Tsurushita, Maximiliano Vasquez
  • Platenolide synthase gene
    Patent number: 5945320
    Abstract: A DNA molecule isolated from Streptomyces ambofaciens encodes the multi-functional proteins which direct the synthesis of the polyketide platenolide.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: August 31, 1999
    Assignee: Eli Lilly and Company
    Inventors: Stanley G. Burgett, Stuart A. Kuhstoss, Ramachandra N. Rao, Mark A. Richardson, Paul R. Rosteck, Jr.
  • Polyketide synthase genes
    Patent number: 5876991
    Abstract: A DNA molecule isolated from Streptomyces fradiae encodes the multi-functional proteins which direct the synthesis of the polyketide tylactone.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: March 2, 1999
    Assignee: Eli Lilly and Company
    Inventors: Bradley S. DeHoff, Stuart A. Kuhstoss, Paul R. Rosteck, Jr., Kimberly L. Sutton
  • Use of the site-specific integrating function of phage .phi.C31
    Patent number: 5190871
    Abstract: The present invention provides a method for transforming an actinomycete with an integrating vector which has the advantages of high transformation rates into a broad host range, site-specific integration, and stable maintenance without antibiotic selection. Also provided are methods for the increased production of antibiotics and for the production of hybrid antibiotics.
    Type: Grant
    Filed: June 12, 1989
    Date of Patent: March 2, 1993
    Assignee: Eli Lilly and Company
    Inventors: Karen L. Cox, Stuart A. Kuhstoss, R. Nagaraja Rao, Mark A. Richardson, Brigitte E. Schoner, Eugene T. Seno
  • Transcription terminator and related recombinant DNA vectors and transformants
    Patent number: 5093252
    Abstract: A transcription terminator is disclosed comprising a DNA sequence capable of functioning as a transcription terminator in a microorganism of the order Actinomycetales. These transcription terminators are functional in both gram-positive and gram-negative microorganisms, especially Streptomyces ambofaciens. Additionally, a series of recombinant DNA cloning vectors suitable for isolating the disclosed transcription terminators are set forth.
    Type: Grant
    Filed: April 30, 1990
    Date of Patent: March 3, 1992
    Assignee: Eli Lilly and Company
    Inventors: Stuart A. Kuhstoss, R. Nagaraja Rao
  • Method of using bacteriophage lambda p.sub.1 promoter to produce a functional polypeptide in streptomyces
    Patent number: 4766066
    Abstract: The invention relates to a method and cloning vehicle for the expression of a functional polypeptide in Streptomyces. A recombinant DNA cloning vehicle was genetically engineered to bring the expression of the neomycin phosphotransferase gene under the control of the Escherichia coli bacteriophage .lambda.p.sub.L promoter.
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: August 23, 1988
    Assignee: Eli Lilly and Company
    Inventors: Stuart A. Kuhstoss, R. Nagaraja Rao
  • Transcription terminators
    Patent number: 4710464
    Abstract: The present transcription terminators are DNA sequences characterized by their ability to terminate the transcription of DNA sequences. The present sequences are portable, have a variety of restriction endonuclease sites and are useful in controlling the expression in hosts of DNA sequences coding for prokaryotic, eukaryotic and viral proteins and polypeptides.
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: December 1, 1987
    Assignee: Eli Lilly and Company
    Inventors: Ramamoorthy Belagaje, Stuart A. Kuhstoss, R. Nagaraja Rao