Abstract: The present invention provides a radiotherapeutic composition comprising a high specific activity tin-117m source of radiotherapeutic atomic electrons and a delivery vehicle, e.g., a chelator or nanosphere or microsphere effective to contain tin-117m therein. The present invention also provides a targeting moiety linked to the delivery vehicle. Further provided are methods of treating a neoplastic bone disease or disorder or imaging the same using the high specific activity radiotherapeutic compositions.

Abstract: Provided herein are methods of producing radium-225 and actinium-225 from an activated radium-226 source. Irradiation of the radium-226 by neutrons with energy effective to drive the reaction 226Ra (n,2n) 225Ra produces abundant radium-225 which decays to its daughter radionuclide actinium-225. Also provided is a system for supplying radiotherapeutic bismuth-213 in situ to a subject in need of radiotherapy using the actinium-225 produced by this method in a generator device effective to generate bismuth-213.

Abstract: The addition of small amounts of rhenium, technitium and their mixtures and, optionally erbium, to a nickel-based superalloy in which the ratio of nickel to chromium is approximately 3-4 to 1, provides enhanced mechanical properties particularly suitable for applications in the manufacture of gas turbine engine components, airframe skins and combustion chambers.

Abstract: The addition of small amounts of rhenium, technitium and their mixtures and, optionally erbium, to a nickel based superalloy consisting essentially of 19.3-19.7 weight percent chromium, about 0.5% carbon, about 2.5% iron, the balance essentially nickel, provides enhanced mechanical properties particularly suitable for applications in gas turbine engine components.