Patents by Inventor Stuart Alexander Cook

Stuart Alexander Cook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of fibrosis
    Patent number: 11939374
    Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: March 26, 2024
    Assignees: Singapore Health Services PTE LTD., National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • Treatment and prevention of metabolic diseases
    Patent number: 11813311
    Abstract: Methods of treating and preventing metabolic disease through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: November 14, 2023
    Assignees: Singapore Health Services PTE LTD., National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer, Brijesh Kumar Singh, Anissa Widjaja
  • Treatment of SMC mediated disease
    Patent number: 11780898
    Abstract: Diagnosis, treatment and prophylaxis of diseases and conditions associated with smooth muscle cell (SMC) dysfunction are provided through the inhibition of IL-11-mediated signalling.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: October 10, 2023
    Assignees: Singapore Health Services PTE LTD., National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer, Wei Wen Lim, Benjamin Wei Ming Ng
  • TREATMENT AND PREVENTION OF DISEASE CAUSED BY TYPE IV COLLAGEN DYSFUNCTION
    Publication number: 20230212279
    Abstract: Methods of treating and preventing Alport syndrome through inhibiting interleukin 11 (EL-11)-mediated signalling are disclosed, as well as agents for use in such methods.
    Type: Application
    Filed: June 17, 2021
    Publication date: July 6, 2023
    Applicants: Singapore Health Services PTE, LTD., National University of Singapore
    Inventors: Stuart Alexander Cook, Anissa Anindya, Sebastian Schaefer
  • TREATMENT OF KIDNEY INJURY
    Publication number: 20220403017
    Abstract: Methods of treating and preventing kidney injury through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.
    Type: Application
    Filed: May 23, 2022
    Publication date: December 22, 2022
    Applicants: National University of Singapore, Singapore Health Services PTE LTD
    Inventors: Stuart Alexander Cook, Sebastian Schaefer, Anissa Anindya Widjaja
  • DECOY CYTOKINE RECEPTOR
    Publication number: 20220298224
    Abstract: An IL-11 binding receptor capable of binding to IL-11 and inhibiting IL-11 mediated signalling is disclosed. Also disclosed are compositions comprising the IL-11 binding receptor and methods using the IL-11 binding receptor.
    Type: Application
    Filed: March 4, 2022
    Publication date: September 22, 2022
    Applicants: National University of Singapore, Singapore Health Services PTE LTD.
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • Treatment of kidney injury
    Patent number: 11339216
    Abstract: Methods of treating and preventing kidney injury through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: May 24, 2022
    Assignees: National University of Singapore, Singapore Health Services PTE LTD.
    Inventors: Stuart Alexander Cook, Sebastian Schaefer, Anissa Anindya Widjaja
  • Treatment of hepatotoxicity with IL-11 antibody
    Patent number: 11319368
    Abstract: Methods of treating and preventing hepatotoxicity through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: May 3, 2022
    Assignees: Singapore Health Services PTE LTD., National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer, Anissa Widjaja
  • Decoy cytokine receptor
    Patent number: 11274143
    Abstract: An IL-11 binding receptor capable of binding to IL-11 and inhibiting IL-11 mediated signalling is disclosed. Also disclosed are compositions comprising the IL-11 binding receptor and methods using the IL-11 binding receptor.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: March 15, 2022
    Assignees: National University of Singapore, Singapore Health Services Pte Ltd
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • IL-11R? antibodies
    Patent number: 11084878
    Abstract: Provided are antigen-binding molecules capable of binding to IL-11R?, and methods of medical treatment and prophylaxis using the same.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: August 10, 2021
    Assignees: National University of Singapore, Singapore Health Services PTE LTD., Boehringer Ingelheim International GmbH
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • IL-11 antibodies
    Patent number: 11084874
    Abstract: Provided are antigen-binding molecules capable of binding to IL-11, and methods of medical treatment and prophylaxis using the same.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: August 10, 2021
    Assignees: Singapore Health Services PTE LTD., National University of Singapore, Boehringer Ingelheim International GmbH
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • COMBINATION TREATMENT FOR EYE FIBROSIS AND/OR ANGIOGENESIS
    Publication number: 20210238272
    Abstract: Methods for the diagnosis, treatment and prophylaxis of fibrosis and/or angiogenesis, in particular in the eye, are disclosed. In particular embodiments, the methods employ antagonism of IL-11 mediated signalling and antagonism of angiogenesis. Also provided are combinations comprising an antagonist of IL-11 mediated signalling and an antagonist of an angiogenic factor.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 5, 2021
    Applicant: Boehringer Ingelheim International GmbH & CO KG
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • IL-11 antibodies
    Patent number: 11078268
    Abstract: IL-11 antibodies are disclosed. Also disclosed are compositions comprising the IL-11 antibodies, and methods using the IL-11 antibodies.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: August 3, 2021
    Assignees: Singapore Health Services PTE LTD, National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • IL-11R? antibodies
    Patent number: 11078269
    Abstract: IL-11R? antibodies are disclosed. Also disclosed are compositions comprising the IL-11R? antibodies, and methods using the IL-11R? antibodies.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: August 3, 2021
    Assignees: Singapore Health Services PTE LTD, National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • IL-11 ANTIBODIES
    Publication number: 20210230266
    Abstract: Provided are antigen-binding molecules capable of binding to IL-11, and methods of medical treatment and prophylaxis using the same.
    Type: Application
    Filed: March 25, 2021
    Publication date: July 29, 2021
    Applicants: Singapore Health Services PTE LTD., National University of Singapore, Boehringer Ingelheim International GmbH
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • TREATMENT OF FIBROSIS
    Publication number: 20210188962
    Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.
    Type: Application
    Filed: December 2, 2020
    Publication date: June 24, 2021
    Applicants: Singapore Health Services PTE LTD., National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • TREATMENT AND PREVENTION OF METABOLIC DISEASES
    Publication number: 20210177940
    Abstract: Methods of treating and preventing metabolic disease through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.
    Type: Application
    Filed: May 1, 2020
    Publication date: June 17, 2021
    Applicants: Singapore Health Services PTE LTD., National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer, Brijesh Kumar Singh, Anissa Widjaja
  • Treatment of fibrosis with Interleukin-11 receptor alpha antibody
    Patent number: 10927169
    Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: February 23, 2021
    Assignees: Singapore Health Services PTE LTD, National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • Treatment of fibrosis with interleukin-11 receptor alpha antibody
    Patent number: 10899832
    Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: January 26, 2021
    Assignees: Singapore Health Services PTE LTD, National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • Treatment of fibrosis with interleukin-11 receptor alpha antibody
    Patent number: 10894827
    Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: January 19, 2021
    Assignees: Singapore Health Services PTE LTD, National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer