Abstract: The presently disclosed dental irrigation device projects irrigates and cleans teeth by directing fluid onto the surfaces of a user's teeth and the interproximal spaces between a user's teeth and gum line. The device comprises two hollow U-shaped manifolds that are arranged in a back to back configuration, with one manifold pointing up and one manifold pointing down. Each manifold has an orifice located on each interior face that is used as a fluid jet to irrigate surfaces between teeth and gum line. The dental irrigation device preferably is part of an overall, self-contained device that includes the dental irrigation device, a fluid source/container, a pump that provides fluid from the container to the dental irrigation device, and a dry battery, independent power source. The self-contained device allows for handheld, cords and/or tubing free use of the self-contained device and accordingly, dental irrigation device.

Abstract: The present invention relates to an article of luggage that is configured to be conveniently rolled or wheeled about when in use as well as readily stored when empty and not in use. The luggage has wheels that are placed on the back side of the luggage, such that in use the luggage is wheeled about in a horizontal position. This position also provides use of the luggage as a cart for additional luggage or items that can be placed or stacked on the luggage while horizontal. The telescopic handle that is mounted in the back of the luggage is rotatable to an upward position when fully extended, to allow a user to ready pull and/or push the horizontal luggage. The luggage further has sides that are compressible/collapsible when not in use, to allow the height of the luggage to be reduced and therefore easier to store by occupying less space than the full size, fully expanded luggage. In addition, the luggage optionally has one or more outlets for charging portable electronic devices.

Abstract: The presently disclosed footstool comprises a collapsible footstool that is useful for conveniently placing one's foot into comfortable reach to facilitate personal grooming, shoe tying, and the like. The collapsible footrest features a height adjustable footrest that positions one's toes at different selected heights relative to the footstool's table top. The table top includes raised edges that form a tray for holding personal grooming tools and the like. The table top likewise preferably includes a drawer for storing tools and like when not in use. The table top further includes one or more USB ports that power/support optional accessories that plug into the table top, such as a light, magnifying lens, and/or a fan.

Abstract: The present invention relates to an ice formation device that can be used to form and store ice and ice cubes. The ice formation device includes an outer bucket, a cylinder, and a lid. The cylinder is sized to snugly fit within the outer bucket to form a water tight seal with the outer bucket. The outer bucket has channels and pockets that are filled with water when the cylinder is inserted into the outer bucket, and the water is frozen to form ice/ice cubes. The cylinder can be re-inserted into the outer bucket after ice is formed and stored in the outer bucket, to allow for subsequent ice formation when the outer bucket contains ice cubes that have been released from the outer bucket's channels and pockets. The ice formation device can also be used as an ice bucket for chilling a bottle or other items that can be placed inside the cylinder once ice has been formed between the cylinder and the outer bucket.

Abstract: The cushion is formed of a plurality of articulately interconnected pillow members in side-by-side relation such that the pillow members can be configured in a variety of different orientations. The pillow members are each formed of a resilient core enclosed in fabric covering. The pillow members each have substantially the same size and cylindrical shape with a flattened bottom. Adjacent pillow members are connected by sections of the fabric. The fabric has top and bottom sections. Resilient cores in spaced, parallel relation are situated on the bottom fabric section. The top fabric section is folded over the resilient cores. The top and bottom sections are stitched together along the fabric between adjacent resilient cores to form a flexible connection.

Abstract: The disclosure provides methods and materials for increasing the expression of a protein of interest such as an antibody by a cell. ABC50 expression or activity is increased which increases expression of the protein or antibody of interest. The disclosure also provides methods and materials for increasing the sensitivity of a cell to an endoplasmic reticulum stress agent such as Econozole by decreasing the level of ABC50.

Abstract: The disclosure provides methods and materials for increasing the expression of a protein of interest such as an antibody by a cell ABC50 expression or activity is increased which increases expression of the protein or antibody of interest. The disclosure also provides methods and materials for increasing the sensitivity of a cell to an endoplasmic reticulum stress agent such as Econazole by decreasing the level of ABC50.

Abstract: The disclosure provides methods and materials for increasing the expression of a protein of interest such as an antibody by a cell. ABC50 expression or activity is increased which increases expression of the protein or antibody of interest. The disclosure also provides methods and materials for increasing the sensitivity of a cell to an endoplasmic reticulum stress agent such as Econozole by decreasing the level of ABC50.

Abstract: Object storage trays provide a tray for storing pots, pans, and their lids. First and second top members and first and second end members form a generally rectangular frame attached to a first center member, a first cross member, and a second cross member. Generally sinusoidal longitudinal members are attached to the first cross member, first center member, and second cross member. Glider brackets are attached beneath the longitudinal members to connect gliders to the object storage tray. Dividers mounted on sliding pivots are attached to the first center member and have lid handle notches in their middles. A telescoping embodiment of the invention is also disclosed that permits adjustments to the width of the object storage tray.

Abstract: Medicine caddies store and organize medicines. A bottom tier with a first shelf, a first wall, and a first divider is slidably and rotatably mounted on a base. A second tier with a second shelf, a second wall, and a second divider is attached to the first wall. Barriers enclose the sides of the first and second walls. Cutouts present in the middle of the first and second walls allow divider hooks on the dividers to be slidably and removably attached to the first and second walls. Barrier slots in the top of the barriers slidably and removably receive barrier hooks attached to the dividers. A second embodiment has a rotation joint between the first and second walls and has its dividers slidably attached to only the first and second walls. Tabs are provided as a perforated sheet and are attached to the barriers by tab holders to identify medicines.

Abstract: The invention provides methods and compositions for loading an agent, such as econazole, onto a liposome for parental delivery. The loading of the agent into a liposome comprises combining the agent with a micelle-forming compound to form a micelle including the agent, where the agent is releasable from the micelle-forming compound, and adding the micelle to the liposome, where the micelle combines with the liposome such that the agent is loaded into the liposome to form a loaded liposome. The methods are suitable for the loading of poorly soluble agents onto liposome.

Abstract: The invention provides methods and compositions for loading an agent onto a liposome for parenteral delivery. The methods are suitable for the loading of poorly soluble agents onto liposomes.

Abstract: The invention relates to a pharmaceutical composition comprising i) ketotifen or an analog thereof and ii) a chemotherapeutic drug subject to multi-drug resistance by P-gp, such as doxorubicin or an analog thereof. The pharmaceutical composition is useful for treating cancer. The pharmaceutical composition is also useful for i) preventing or treating multi-drug resistance in a subject or ii) preventing a chemotherapeutic drug subject to multi-drug resistance by P-gp induced cardiac tissue damage in a subject, such as doxorubicin or an analog thereof. The invention relates to a pharmaceutical composition comprising i) ketotifen or an analog thereof and ii) a chemotherapeutic drug subject to multi-drug resistance by P-gp, such as doxorubicin or an analog thereof. The pharmaceutical composition is useful for treating cancer.

Abstract: A holder device for holding paper articles and writing instruments includes a housing having a pair of compartments therein. A permanent magnet is mounted on the housing and is removably received on a ferrous metallic bar which is mounted on a stationary object. An ejector assembly is contained in one of the compartments for ejecting the writing instruments from the compartment.